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Radotinib Dihydrochloride

CAS No.
926037-85-6
Chemical Name:
Radotinib Dihydrochloride
Synonyms
Radotinib Dihydrochloride
CBNumber:
CB62728623
Molecular Formula:
C27H22ClF3N8O
Molecular Weight:
566.97
MDL Number:
MFCD33029238
MOL File:
926037-85-6.mol
Last updated:2022-12-21 16:56:50

Radotinib Dihydrochloride Properties

FDA UNII EF516G9REZ

Radotinib Dihydrochloride Chemical Properties,Uses,Production

Clinical Use

In January 2012, radotinib hydrochloride (marketed as Supect ®) obtained its approval from the KFDA (Korea Food and Drug Administration) for the treatment of patients with Philadelphia chromosomepositive chronic myeloid leukemia (CML) who have become resistant to existing drugs such as Gleevec, Tasigna and Sprycel. Originally developed by IL-YANG pharmaceuticals of South Korea as an orally second-generation tyrosine kinase inhibitor, the drug inhibits both Bcr-Abl fusion protein and the platelet-derived growth factor receptor (PDGFR).

Synthesis

Because of the structural similarity of radotinib to that of nilotinib (Tasigna ®), the process-scale synthetic route (which is depicted in the scheme) is capable of furnishing both drugs.Claisen condensation of commerical 2-acetylpyrazine (142) with N,N-dimethylformamide dimethylacetal gave rise to the enamino ketone 143 in 81% yield. Under basic conditions, vinylogous amide 143 was coupled with commercial guanidine nitrate 144187 to produce aminopyridine 145. Subsequent condensation with commercial aniline (146) by means of potassium t-butoxide in THF constructed radotinib 147 in 85% yield as the free base, and this material could be converted to the radotinib dihydrochloride (XXII) upon exposure to concentrated hydrochloric acid in chilled acetone. Synthesis_926037-85-6

Radotinib Dihydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

Radotinib Dihydrochloride Suppliers

Global( 9)Suppliers
Supplier Tel Email Country ProdList Advantage
LEAPCHEM CO., LTD.
+86-852-30606658 market18@leapchem.com China 43348 58
Taizhou Tongxin Bio-Tech Co., Ltd 0523-18601685-898 18652728585 sales@allyrise.com China 2776 60
Taizhou Ruixin Chemical Co., Ltd. 0576-89085261 15867635987 jasonhu09@163.com China 442 50
ShangHai Biochempartner Co.,Ltd 17754423994 17754423994 2853530910@QQ.com China 8013 62
Twochem Co.Ltd. 021-58111628 15800915896 sales@twochem.com China 1789 58
Tianjin Kaifu Pharmaceutical Technology Co., Ltd. 18081075745 chemflowtech@sina.com China 1886 58
Chunchuang (Wuhan) Technology Co., Ltd 15342225168 yutianchun2007@126.com China 10001 58
Wuhan Yingnuo Pharmaceutical Technology Co., Ltd. +86-027-59232304 15387063101 2881924050@qq.com China 9934 58
Olix (Shanghai) Pharmaceutical Technology Co., Ltd 17316404525 209533805@qq.com China 9653 58
Radotinib Dihydrochloride 926037-85-6