Radotinib Dihydrochloride
- CAS No.
- 926037-85-6
- Chemical Name:
- Radotinib Dihydrochloride
- Synonyms
- Radotinib Dihydrochloride
- CBNumber:
- CB62728623
- Molecular Formula:
- C27H22ClF3N8O
- Molecular Weight:
- 566.97
- MDL Number:
- MFCD33029238
- MOL File:
- 926037-85-6.mol
FDA UNII | EF516G9REZ |
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Radotinib Dihydrochloride Chemical Properties,Uses,Production
Clinical Use
In January 2012, radotinib hydrochloride (marketed as Supect ®) obtained its approval from the KFDA (Korea Food and Drug Administration) for the treatment of patients with Philadelphia chromosomepositive chronic myeloid leukemia (CML) who have become resistant to existing drugs such as Gleevec, Tasigna and Sprycel. Originally developed by IL-YANG pharmaceuticals of South Korea as an orally second-generation tyrosine kinase inhibitor, the drug inhibits both Bcr-Abl fusion protein and the platelet-derived growth factor receptor (PDGFR).
Synthesis
Because of the structural similarity of radotinib to that of nilotinib (Tasigna ®), the process-scale synthetic route (which is depicted in the scheme) is capable of furnishing both drugs.Claisen condensation of commerical 2-acetylpyrazine (142) with N,N-dimethylformamide dimethylacetal gave rise to the enamino ketone 143 in 81% yield. Under basic conditions, vinylogous amide 143 was coupled with commercial guanidine nitrate 144187 to produce aminopyridine 145. Subsequent condensation with commercial aniline (146) by means of potassium t-butoxide in THF constructed radotinib 147 in 85% yield as the free base, and this material could be converted to the radotinib dihydrochloride (XXII) upon exposure to concentrated hydrochloric acid in chilled acetone.
Radotinib Dihydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
Radotinib Dihydrochloride Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43348 | 58 |
Taizhou Tongxin Bio-Tech Co., Ltd | 0523-18601685-898 18652728585 | sales@allyrise.com | China | 2776 | 60 |
Taizhou Ruixin Chemical Co., Ltd. | 0576-89085261 15867635987 | jasonhu09@163.com | China | 442 | 50 |
ShangHai Biochempartner Co.,Ltd | 17754423994 17754423994 | 2853530910@QQ.com | China | 8013 | 62 |
Twochem Co.Ltd. | 021-58111628 15800915896 | sales@twochem.com | China | 1789 | 58 |
Tianjin Kaifu Pharmaceutical Technology Co., Ltd. | 18081075745 | chemflowtech@sina.com | China | 1886 | 58 |
Chunchuang (Wuhan) Technology Co., Ltd | 15342225168 | yutianchun2007@126.com | China | 10001 | 58 |
Wuhan Yingnuo Pharmaceutical Technology Co., Ltd. | +86-027-59232304 15387063101 | 2881924050@qq.com | China | 9934 | 58 |
Olix (Shanghai) Pharmaceutical Technology Co., Ltd | 17316404525 | 209533805@qq.com | China | 9653 | 58 |