Spermine
- CAS No.
- 71-44-3
- Chemical Name:
- Spermine
- Synonyms
- SPERMINE TETRAHYDROCHLORIDE;Spermin;NEURIDINE HYDROCHLORIDE;MUSCULAMINE HYDROCHLORIDE;DJtPAT;Spermine;NSC 268508;Spermine,97%;Spermine >98%;SOYASAPONIN IV(SH)
- CBNumber:
- CB6275334
- Molecular Formula:
- C10H26N4
- Molecular Weight:
- 202.34
- MDL Number:
- MFCD00012914
- MOL File:
- 71-44-3.mol
- MSDS File:
- SDS
| Melting point | 28-30 (lit.) |
|---|---|
| Boiling point | 150 °C/5 mmHg (lit.) |
| Density | 0.937 |
| refractive index | 1.4850 (estimate) |
| Flash point | >230 °F |
| storage temp. | 2-8°C |
| solubility | H2O: 1 M at 20 °C, clear, colorless |
| form | powder |
| pka | 10.88±0.19(Predicted) |
| color | Colorless to off-white |
| Water Solubility | Soluble in chloroform, methanol, water and lower alcohols. Insoluble in ether, benzene and petroleum ether. |
| Sensitive | Air Sensitive & Hygroscopic |
| Merck | 14,8743 |
| BRN | 1751791 |
| Stability | Hygroscopic |
| InChIKey | PFNFFQXMRSDOHW-UHFFFAOYSA-N |
| LogP | -0.543 (est) |
| CAS DataBase Reference | 71-44-3(CAS DataBase Reference) |
| FDA UNII | 2FZ7Y3VOQX |
| NIST Chemistry Reference | Spermine(71-44-3) |
| EPA Substance Registry System | 1,4-Butanediamine, N,N'-bis(3-aminopropyl)- (71-44-3) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS05 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H318-H314 | |||||||||
| Precautionary statements | P260h-P301+P330+P331-P303+P361+P353-P405-P501a-P280-P305+P351+P338-P310 | |||||||||
| Hazard Codes | Xi,C | |||||||||
| Risk Statements | 36/38-34 | |||||||||
| Safety Statements | 26-36-45-36/37/39-27 | |||||||||
| RIDADR | UN 3259 8/PG 2 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | EJ7230000 | |||||||||
| F | 3-10 | |||||||||
| TSCA | Yes | |||||||||
| HazardClass | 8 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29212900 | |||||||||
| NFPA 704 |
|
Spermine price More Price(32)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 85590 | Spermine ≥99.0% (GC) | 71-44-3 | 5g | $321 | 2024-03-01 | Buy |
| Sigma-Aldrich | 55513 | Spermine analytical standard | 71-44-3 | 100mg | $73.6 | 2024-03-01 | Buy |
| Alfa Aesar | L19562 | Spermine, 97% | 71-44-3 | 1g | $58.9 | 2024-03-01 | Buy |
| Alfa Aesar | L19562 | Spermine, 97% | 71-44-3 | 5g | $188 | 2024-03-01 | Buy |
| Cayman Chemical | 18041 | Spermine ≥95% | 71-44-3 | 1g | $37 | 2024-03-01 | Buy |
Spermine Chemical Properties,Uses,Production
Description
Spermine is an endogenous polyamine synthesized from the reaction of spermidine with decarboxylated S-adenosylmethionine in the presence of the enzyme spermine synthase and is required for eukaryotic cell growth and protein synthesis. Intracellular spermine blocks inward rectifying K+ channels, whereas extracellular spermine acts as a mixed NMDA glutamate receptor agonist/antagonist at the polyamine site. Spermine has neuroprotective and anti-inflammatory effects and functions as a free radical scavenger to prevent DNA damage by reactive oxygen species.
Chemical Properties
White to slightly off-white powder crysta
Uses
immune modulator
Uses
Biogenic polyamine formed from spermidine and occurring in almost all tissues. Essential for both normal and neoplastic tissue growth. Involved in the modulation of calcium-dependent immune processes
Uses
Binds to the polyamine modulatory site of NMDA Spermine is essential for both normal and neoplastic tissue growth. It is involved in the modulation of calcium-dependent immune processes. It plays an important role in cellular proliferation and differentiation as well as inhibits neuronal nitric oxide synthase (nNOS).
Definition
ChEBI: A polyazaalkane that is tetradecane in which the carbons at positions 1, 5, 10 and 14 are replaced by nitrogens. Spermine has broad actions on cellular metabolism.
General Description
Spermine?is a polyamine, which functions as a free radical scavenger. It modulates gene expression, chromatin stabilization and prevents DNA damage. Spermine inhibits endonuclease-mediated DNA fragmentation.
Biochem/physiol Actions
Mixed NMDA glutamate receptor agonist/antagonist at the polyamine site. Neuroprotective effects have been observed at high concentrations (1 mM), while neurotoxicity is observed at lower concentrations. It enhances agonist effectiveness at the strychnine-insensitive glycine site. Plays a role in cellular proliferation and differentiation; inhibits neuronal nitric oxide synthase (nNOS).
storage
+4°C (desiccate)
References
[1] fakler b, brndle u, glowatzki e, et al. strong voltage-dependent inward rectification of inward rectifier k+ channels is caused by intracellular spermine[j]. cell, 1995, 80(1): 149-154.
[2] til h p, falke h e, prinsen m k, et al. acute and subacute toxicity of tyramine, spermidine, spermine, putrescine and cadaverine in rats[j]. food and chemical toxicology, 1997, 35(3): 337-348.
Spermine Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Nanjing Paron Technology Co., Ltd | +8613770590702 | arthur@parontek.com | China | 227 | 58 |
| Hebei Mojin Biotechnology Co., Ltd | +86 13288715578 +8613288715578 | sales@hbmojin.com | China | 12834 | 58 |
| Shaanxi Haibo Biotechnology Co., Ltd | +undefined18602966907 | qinhe02@xaltbio.com | China | 997 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20283 | 58 |
| Hangzhou Hyper Chemicals Limited | +86-0086-57187702781 +8613675893055 | info@hyper-chem.com | China | 295 | 58 |
| Hebei Zhuanglai Chemical Trading Co Ltd | +86-16264648883 +86-16264648883 | niki@zlchemi.com | China | 3001 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29791 | 60 |
| Hangzhou FandaChem Co.,Ltd. | +8615858145714 | FandaChem@Gmail.com | China | 8946 | 55 |
| Jinan Carbotang Biotech Co.,Ltd. | +8615866703830 | figo.gao@foxmail.com | China | 8497 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28172 | 58 |
View Lastest Price from Spermine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-12-27 | Spermine
71-44-3
|
US $150.00 / kg | 1kg | 99% | 500kg | Hebei Zhuanglai Chemical Trading Co Ltd | |
 |
2024-11-19 | Spermine
71-44-3
|
US $58.00-41.00 / mg | 99.96% | 10g | TargetMol Chemicals Inc. | ||
 |
2024-11-01 | Spermine
71-44-3
|
US $0.00-0.00 / KG | 1KG | 99% | 5,000KG | Hangzhou Hyper Chemicals Limited |