LORMETAZEPAM
- CAS No.
- 848-75-9
- Chemical Name:
- LORMETAZEPAM
- Synonyms
- Loramet;WY-4082;Ergocalm;Noctamid;RO 5-5516;LORMETAZEPAM;lormethazepam;METHYLLORAZEPAM;N-Methyllorazepam;(RS)-Lormetazepam
- CBNumber:
- CB6277893
- Molecular Formula:
- C16H12Cl2N2O2
- Molecular Weight:
- 335.18
- MDL Number:
- MFCD00058578
- MOL File:
- 848-75-9.mol
Melting point | 163-168°C |
---|---|
Boiling point | 575.8±50.0 °C(Predicted) |
Density | 1.4463 (rough estimate) |
refractive index | 1.6100 (estimate) |
Flash point | 9℃ |
storage temp. | Controlled Substance, -20°C Freezer |
solubility | DMSO (Slightly), Methanol (Slightly) |
form | Solid |
pka | 11.60±0.40(Predicted) |
color | Pale Yellow to Pale Green |
EWG's Food Scores | 1 |
FDA UNII | GU56C842ZA |
ATC code | N05CD06 |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS02,GHS06,GHS08 |
---|---|
Signal word | Danger |
Hazard statements | H225-H301+H311+H331-H370 |
Precautionary statements | P210-P260-P280-P301+P310-P311 |
Hazard Codes | F,T |
Risk Statements | 11-23/24/25-39/23/24/25-22 |
Safety Statements | 7-16-36/37-45-36 |
RIDADR | 3249 |
WGK Germany | 1 |
HazardClass | 6.1(b) |
PackingGroup | III |
LORMETAZEPAM Chemical Properties,Uses,Production
Chemical Properties
Pale Green Solid
Originator
Loramet ,Wyeth, W. Germany,1980
Uses
An analog of Lorazepam (L469850). Sedative, hypnotic. Controlled substance (depressant).
Definition
ChEBI: Lormetazepam is a 1,4-benzodiazepinone compound having a methyl substituent at the 1-position, a hydroxy substituent at the 3-position, a 2-chlorophenyl group at the 5-position and a chloro substituent at the 7-position. It has a role as a sedative. It is a 1,4-benzodiazepinone and an organochlorine compound.
Manufacturing Process
To a suspension of 3.4 g of 3-acetoxy-7-chloro-1,3-dihydro-5-(ochlorophenyl)-2H-1,4-benzodiazepin-2-one in 80 ml of alcohol was added 6 ml of 4 N sodium hydroxide. After complete solution had taken place a solid precipitated that redissolved upon the addition of 80 ml of water. The solution was acidified with acetic acid to give white crystals. After recrystallization from alcohol the compound melted at 192°C to 194°C.
Therapeutic Function
Hypnotic