ChemicalBook >> CAS DataBase List >>1-(4-Chlorobenzhydryl)piperazine
1-(4-Chlorobenzhydryl)piperazine
- CAS No.
- 303-26-4
- Chemical Name:
- 1-(4-Chlorobenzhydryl)piperazine
- Synonyms
- Norchlorcyclizine;Hydroxyzine Related CoMpound A;1-[(4-CHLORO-PHENYL)-PHENYL-METHYL]-PIPERAZINE;NSC 8616;USP CBHP;NSC 86164;UNII:T875VN0D6E;AKOS BBS-00003606;Cetirizine USP A;TIMTEC-BB SBB002998
- CBNumber:
- CB6297354
- Molecular Formula:
- C17H19ClN2
- Molecular Weight:
- 286.8
- MDL Number:
- MFCD00005965
- MOL File:
- 303-26-4.mol
- MSDS File:
- SDS
Last updated:2024-11-19 20:33:22
| Melting point | 65-70 °C (lit.) |
|---|---|
| Boiling point | 178-180 °C/0.5 mmHg (lit.) |
| Density | 1.0912 (rough estimate) |
| vapor pressure | 0Pa at 25℃ |
| refractive index | 1.5749 (estimate) |
| Flash point | >230 °F |
| storage temp. | 2-8°C |
| solubility | soluble in Methanol |
| form | Crystalline Powder |
| pka | 8.99±0.10(Predicted) |
| color | White to light beige |
| Water Solubility | 144.6mg/L at 25℃ |
| LogP | 3.4 at 25℃ |
| CAS DataBase Reference | 303-26-4(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| FDA UNII | T875VN0D6E |
| NIST Chemistry Reference | Piperazine, 1-[(4-chlorophenyl)phenylmethyl]-(303-26-4) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |    GHS05,GHS07,GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H315-H317-H318-H361fd | |||||||||
| Precautionary statements | P201-P202-P280-P302+P352-P305+P351+P338-P308+P313 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-37/39-24/25 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | TL1772000 | |||||||||
| Hazard Note | Irritant | |||||||||
| HS Code | 29339900 | |||||||||
| NFPA 704 |
|
1-(4-Chlorobenzhydryl)piperazine price More Price(35)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | PHR2872 | Hydroxyzine Related Compound A pharmaceutical secondary standard, certified reference material | 303-26-4 | 50MG | $461 | 2024-03-01 | Buy |
| Sigma-Aldrich | C24507 | 1-(4-Chlorobenzhydryl)piperazine technical grade, 90% | 303-26-4 | 1g | $53.2 | 2024-03-01 | Buy |
| Sigma-Aldrich | 1333058 | Hydroxyzine Related Compound A United States Pharmacopeia (USP) Reference Standard | 303-26-4 | 25mg | $1490 | 2024-03-01 | Buy |
| TCI Chemical | C1611 | 1-(4-Chlorobenzhydryl)piperazine >98.0%(GC) | 303-26-4 | 1g | $47 | 2024-03-01 | Buy |
| TCI Chemical | C1611 | 1-(4-Chlorobenzhydryl)piperazine >98.0%(GC) | 303-26-4 | 5g | $136 | 2024-03-01 | Buy |
1-(4-Chlorobenzhydryl)piperazine Chemical Properties,Uses,Production
Chemical Properties
White Solid
Uses
A metabolite of Cetirizine (C281100) and Hydroxyzine. Citirizine impurity A.
Uses
Cetrizine Dihydrochloride intermediate
Preparation
Preparation of 1-[(4-chlorophenyl)phenylmethyl]piperazine. (CPMP)
About 0.5 mL of DMF, 0.1 g of KI and 10 g (0.12 mol) of piperazine were mixed with 15 mL of toluene and heated to 80oC for 0.5 h. This mixture at 80oC was mixed with 4-CBC in toluene and the temperature was maintained at 80oC for a period of 2 h followed by refluxing at the same temperature for 12h. The reaction mixture was then cooled to 20oC. The toluene layer was washed twice with 20 mL of water and treated with HCl (15 mL conc. HCl in 5mL of water) at 5-10oC. The reaction mixture was filtered and the aqueous layer was separated from the filtrate. About 10 mL of toluene and 10 mL of methylene dichloride (MDC) washes were given to the aqueous layer and neutralized with 22 mL of 30 % NaOH solution at 10oC and maintained at 20oC for 2h. The solid compound formed was filtered, sucked and dried at 50oC for 3 h.Yield: 92 %; m.p: 63-65oC.
Flammability and Explosibility
Not classified
Safety Profile
An experimental teratogen.Experimental reproductive effects. When heated todecomposition it emits very toxic fumes of NOx and Clí.
1-(4-Chlorobenzhydryl)piperazine Preparation Products And Raw materials
Raw materials
1of4
Preparation Products
Global( 340)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shaanxi Dideu Medichem Co. Ltd | +86-029-81138252 +86-18789408387 | 1057@dideu.com | China | 3958 | 58 |
| Hebei Yanxi Chemical Co., Ltd. | +8617531190177 | peter@yan-xi.com | China | 5857 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29791 | 60 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21634 | 55 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32957 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29884 | 58 |
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10310 | 58 |
| Xiamen AmoyChem Co., Ltd | +86-86-5926051114 +8618959220845 | sales@amoychem.com | China | 6383 | 58 |
| Standardpharm Co. Ltd. | 86-714-3992388 | overseasales1@yongstandards.com | United States | 14332 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | sales@chemdad.com | China | 39894 | 58 |
View Lastest Price from 1-(4-Chlorobenzhydryl)piperazine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-11-19 | Norchlorcyclizine
303-26-4
|
US $30.00 / g | 97.27% | 10g | TargetMol Chemicals Inc. | ||
 |
2024-10-25 | 1-(4-Chlorobenzhydryl)piperazine
303-26-4
|
US $0.00 / kg | 1kg | 0.99 | 20tons | Hebei Yanxi Chemical Co., Ltd. | |
 |
2024-09-24 | 1-(4-Chlorobenzhydryl)piperazine
303-26-4
|
US $0.00 / kg | 1kg | 98% | 200kg | Shanghai Joiny Pharmaceutical Co.,LTD |
-
- Norchlorcyclizine
303-26-4
- US $30.00 / g
- 97.27%
- TargetMol Chemicals Inc.
-
- 1-(4-Chlorobenzhydryl)piperazine
303-26-4
- US $0.00 / kg
- 0.99
- Hebei Yanxi Chemical Co., Ltd.
-
- 1-(4-Chlorobenzhydryl)piperazine
303-26-4
- US $0.00 / kg
- 98%
- Shanghai Joiny Pharmaceutical Co.,LTD
303-26-4(1-(4-Chlorobenzhydryl)piperazine)Related Search:
2-Diphenylmethylpiperidine hydrochloride
1-Methylpiperazine
2-Methylpiperazine
4-(Chloromethyl)benzoic acid
Vinylbenzyl chloride
1-BENZHYDRYLPIPERAZINE
tert-Butyldimethylsilyl chloride
1,2-Dimethylhydrazine Dihydrochloride
DIMETHYLTHEXYLSILYL CHLORIDE
Piperazine
1of4
Levocetrizine EP IMpurity A
1-(1-4-Chlorobenzhdryl) piperazine
Meclozine impurity H
Cetirizine EP Impurity A
1-(4-Chloro-alpha-phenylbenzyl)piperazine
1-(alpha-Phenyl-4-chlorobenzyl)piperazine
1-(p-chloro-alpha-phenylbenzyl)-piperazin
4-(4-Chlorobenzhydryl)piperazine
Piperazine, 1-(alpha-(4-chlorophenyl)benzyl)-
Piperazine, 1-(p-chloro-alpha-phenylbenzyl)-
N-(4-Chlorophenyl)phenylmethylpiperazine
1-(4-CHLOROBENZHYDRYL)PIPERAZINE, TECH.,
4-(Chlorobenzhydryl)Piperazine(Purified)Hydroxyzine/CetirizineEp
AKOS BBS-00003606
1-(4-CHLOROBENZHYDRYL)PIPERAZINE
1-(4-CHLORODIPHENYLMETHYL)-PIPERAZINE
1-(4-CHLOROPHENYLMETHYL)PIPERAZINE
N-(4-CHLOROBENZYLHYDRYL)PIPERAZINE
N-(4-CHLOROBENZHYDRYL)-PIPERAZINE
N-(P-CHLOROBENZHYDRYL)-PIPERAZINE
TIMTEC-BB SBB002998
1-(4-Chlorobenzhydryl)piperazine, 90-95%
1-(p-Chloro-a-phenylbenzyl)-piperazine
NSC 8616
1-(p-chloro-alpha-phenylbenzyl)-piperazine
1-(4-Chlorobenzhydryl)piperazine technical grade, 90%
1-(4-Chlorobenzhydryl)-piperizine
1-((4-chlorophenyl)phenylmethyl)-piperazin
1-(4-CHLOROBENZYLHYDRYL) PIPERAZINE
(1-(p-Chloro- -phenylbenzyl)-piperazine
Piperazine, 1-[(4-chlorophenyl)phenylmethyl]-
NSC 86164
1-(4-Chloro-a-phenylbenzyl)piperazine
4-(α-Piperazinobenzyl)phenyl chloride
1-(4-Chlorobenzhydry)piperazine
Piperazine, 1-(alpha-(4-chloropheny
Hydroxyzine Related Compound A (25 mg) (p-Chlorobenzhydrylpiperazine)
1-(4-Chlorobenzhydryl)piperazine, 90-95% 5GR
1-(4-chlorobenzhydryl)
Buclizine HCl IMpurity (BP/EP)
Cetirizine IMpurity-A(EP/BP)
Hydroxyzine EP Impurity A
Cetirizine -EP-Imp-A
Cetirizine Impurity 9（Cetirizine EP Impurity A）
Buclizine Impurity 1
Hydroxyzine Related Compound A (1-[(4-Chlorophenyl)phenylmethyl]piperazine) (1333058)
Meclozine impurity H (Y0001311)
Cetirizine EP impurity AQ: What is
Cetirizine EP impurity A Q: What is the CAS Number of
Cetirizine EP impurity A Q: What is the storage condition of
Cetirizine EP impurity A
Cetirizine impurity A (C0980651)
N-(4-Chloro Benzhydryl)Piperazine/1-(4-Chlorobenzhydryl)piperazine
Cetirizine Impurity99
Levocetirizine EP Impurity A/Hydroxyzine EP Impurity A
Hydroxyzine EP Impurity A/ Hydroxyzine Related Compound A (Cetirizine EP Impurity A/ Cetirizine Related Compound A/ Cetirizine CBHP Impurity)
Cetirizine EP Impurity A/ Cetirizine Related Compound A (Cetirizine CBHP Impurity/ Hydroxyzine EP Impurity A/ Hydroxyzine Related Compound A)
Cetirizine
USP A
Meclozine EP Impurity H
USP CBHP
Meclizine EP Impurity H