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Z-LEU-LEU-GLU-AMC

CAS No.
348086-66-8
Chemical Name:
Z-LEU-LEU-GLU-AMC
Synonyms
Z-ILE-AMC;Z-LLE-AMC;Z-LLG-AMC;Z-LEU-LEU-GLU-MCA;Z-LEU-LEU-GLU-AMC;Z-LEU-LEU-GLY-AMC;CBZ-LEU-LEU-GLU-AMC;Proteasome Substrate II;Cbz-Leu-Leu-Glu-AMC, Z-LLE-AMC;PROTEASOME SUBSTRATE II (FLUOROGENIC)
CBNumber:
CB6298942
Molecular Formula:
C35H44N4O9
Molecular Weight:
664.75
MDL Number:
MFCD01074989
MOL File:
348086-66-8.mol
Last updated:2024-10-23 13:36:13

Z-LEU-LEU-GLU-AMC Properties

Boiling point 967.8±65.0 °C(Predicted)
Density 1.253±0.06 g/cm3(Predicted)
storage temp. -20°C
solubility DMSO: soluble
form solid
pka 4.43±0.10(Predicted)
color Solid lyophilized powder

SAFETY

Risk and Safety Statements

Safety Statements  22-24/25
WGK Germany  3

Z-LEU-LEU-GLU-AMC price More Price(15)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich C0483 Z-Leu-Leu-Glu-7-amido-4-methylcoumarin ≥95%, solid 348086-66-8 5MG $404 2023-06-20 Buy
Alfa Aesar J64613 Z-Leu-Leu-Glu-7-amino-4-methylcoumarin 348086-66-8 5mg $141 2023-06-20 Buy
Cayman Chemical 10008117 Z-LLE-AMC ≥95% 348086-66-8 1mg $44 2024-03-01 Buy
Cayman Chemical 10008117 Z-LLE-AMC ≥95% 348086-66-8 5mg $130 2024-03-01 Buy
Cayman Chemical 10008117 Z-LLE-AMC ≥95% 348086-66-8 10mg $235 2024-03-01 Buy
Product number Packaging Price Buy
C0483 5MG $404 Buy
J64613 5mg $141 Buy
10008117 1mg $44 Buy
10008117 5mg $130 Buy
10008117 10mg $235 Buy

Z-LEU-LEU-GLU-AMC Chemical Properties,Uses,Production

Description

Z-LLE-AMC is a fluorogenic substrate for the caspase-like post-glutamate peptide hydrolase of the 26S proteasome or 20S proteolytic core. Caspase-like activity can be quantified by fluorescent detection of free AMC (also known as 7-amino-4-methylcoumarin), which is excited at 340-360 nm and emits at 440-460 nm. Z-LLE-AMC is typically used in cell lysates after experimental treatment.

Uses

A fluorogenic substrate for the peptidylglutamyl-peptide hydrolysing (caspase-like) activity of the proteasome which may be stimulated in the presence of Mg2+ ions and rapidly inactivated by N-acetylimidazole

Uses

Z-Leu-Leu-Glu-7-amido-4-methylcoumarin has been used as a fluorogenic substrate for peptidyl glutamyl peptide hydrolase (PGPH) in rat soleus muscle, neonatal cardiomyocytes and rat brain samples.

General Description

Z-Leu-Leu-Glu-7-amido-4-methylcoumarin is a fluoropeptide. It acts as a substrate for caspase-like activity.

Biochem/physiol Actions

Fluorogenic substrate for the measurement of the peptidylglutamyl-peptide hydrolyzing activity of the 20S proteasome.

storage

+4°C

Z-LEU-LEU-GLU-AMC Preparation Products And Raw materials

Raw materials

Preparation Products

Z-LEU-LEU-GLU-AMC Suppliers

Global( 88)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32161 58
Career Henan Chemica Co
+86-0371-86658258 +8613203830695 laboratory@coreychem.com China 30239 58
BOC Sciences
16314854226; +16314854226 inquiry@bocsci.com United States 19741 58
Zhejiang J&C Biological Technology Co.,Limited
+1-2135480471 +1-2135480471 sales@sarms4muscle.com China 10473 58
Nextpeptide Inc
+86-0571-81612335 +8613336028439 sales@nextpeptide.com China 19908 58
Chengdu Youngshe Chemical Co., Ltd.
+8618108235634 Cecilia@youngshechem.com China 2345 58
Nanjing TGpeptide
+86-13347807150 +86-13347807150 support@tgpeptide.com China 3279 58
Zhejiang Hangyu API Co., Ltd
+8617531972939 anna@api-made.com China 2943 58
Changsha MOL Changes Biotechnology Co., Ltd.
+8619375158599 info@molchanges.com China 5223 58
DONBOO AMINO ACID COMPANY
+8613063595538 donboo@donboo.com China 9363 58

View Lastest Price from Z-LEU-LEU-GLU-AMC manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Z-LLE-AMC pictures 2024-10-24 Z-LLE-AMC
348086-66-8
US $588.00-325.00 / mg 10g TargetMol Chemicals Inc.
  • Z-LLE-AMC pictures
  • Z-LLE-AMC
    348086-66-8
  • US $588.00-325.00 / mg
  • TargetMol Chemicals Inc.
CBZ-LEU-LEU-GLU-AMC CARBOBENZOXY-L-LEUCYL-L-LEUCYL-L-GLUTAMIC-ACID-ALPHA-(4-METHYLCOUMARINYL)-7-AMIDE BENZYLOXYCARBONYL-L-LEUCYL-L-LEUCYL-L-GLUTAMIC ACID ALPHA-(4-METHYLCOUMARYL-7-AMIDE) PROTEASOME SUBSTRATE II (FLUOROGENIC) Z-LEU-LEU-GLU-7-AMIDO-4-METHYLCOUMARIN Z-LEU-LEU-GLU-7-AMINO-4-METHYLCOUMARIN Z-LEU-LEU-GLU-AMC Z-LEU-LEU-GLU-MCA Z-LLE-AMC Z-ILE-AMC N-[(Phenylmethoxy)carbonyl]-L-leucyl-L-leucyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-L-alpha-glutamine Z-LLG-AMC Cbz-Leu-Leu-Glu-AMC, Z-LLE-AMC (5S,8S,11S)-5,8-Diisobutyl-11-((4-methyl-2-oxo-2H-chromen-7-yl)carbamoyl)-3,6,9-trioxo-1-phenyl-2-oxa-4,7,10-triazatetradecan-14-oic acid Z-LEU-LEU-GLY-AMC benzyloxycarbonyl-L-leucyl-L-leucyl-L-glutamic acid α-(4-methylcoumaryl-7-amide) Proteasome Substrate II L-α-Glutamine, N-[(phenylmethoxy)carbonyl]-L-leucyl-L-leucyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)- 348086-66-8 C35H44N4O9 Proteasome substrate II.