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ChemicalBook >> CAS DataBase List >>Z-LEU-LEU-GLU-AMC

Z-LEU-LEU-GLU-AMC

Z-LEU-LEU-GLU-AMC Structure
Z-LEU-LEU-GLU-AMC structure
CAS No.
348086-66-8
Chemical Name:
Z-LEU-LEU-GLU-AMC
Synonyms
Z-ILE-AMC;Z-LLE-AMC;Z-LLG-AMC;Z-LEU-LEU-GLU-MCA;Z-LEU-LEU-GLU-AMC;Z-LEU-LEU-GLY-AMC;CBZ-LEU-LEU-GLU-AMC;Proteasome Substrate II;Cbz-Leu-Leu-Glu-AMC, Z-LLE-AMC;PROTEASOME SUBSTRATE II (FLUOROGENIC)
CBNumber:
CB6298942
Molecular Formula:
C35H44N4O9
Molecular Weight:
664.75
MDL Number:
MFCD01074989
MOL File:
348086-66-8.mol
Last updated:2024-10-23 13:36:13
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Z-LEU-LEU-GLU-AMC Properties

Boiling point 967.8±65.0 °C(Predicted)
Density 1.253±0.06 g/cm3(Predicted)
storage temp. -20°C
solubility DMSO: soluble
form solid
pka 4.43±0.10(Predicted)
color Solid lyophilized powder

SAFETY

Risk and Safety Statements

Safety Statements  22-24/25
WGK Germany  3

Z-LEU-LEU-GLU-AMC price More Price(15)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich C0483 Z-Leu-Leu-Glu-7-amido-4-methylcoumarin ≥95%, solid 348086-66-8 5MG $404 2023-06-20 Buy
Alfa Aesar J64613 Z-Leu-Leu-Glu-7-amino-4-methylcoumarin 348086-66-8 5mg $141 2023-06-20 Buy
Cayman Chemical 10008117 Z-LLE-AMC ≥95% 348086-66-8 1mg $44 2024-03-01 Buy
Cayman Chemical 10008117 Z-LLE-AMC ≥95% 348086-66-8 5mg $130 2024-03-01 Buy
Cayman Chemical 10008117 Z-LLE-AMC ≥95% 348086-66-8 10mg $235 2024-03-01 Buy
Product number Packaging Price Buy
C0483 5MG $404 Buy
J64613 5mg $141 Buy
10008117 1mg $44 Buy
10008117 5mg $130 Buy
10008117 10mg $235 Buy

Z-LEU-LEU-GLU-AMC Chemical Properties,Uses,Production

Description

Z-LLE-AMC is a fluorogenic substrate for the caspase-like post-glutamate peptide hydrolase of the 26S proteasome or 20S proteolytic core. Caspase-like activity can be quantified by fluorescent detection of free AMC (also known as 7-amino-4-methylcoumarin), which is excited at 340-360 nm and emits at 440-460 nm. Z-LLE-AMC is typically used in cell lysates after experimental treatment.

Uses

A fluorogenic substrate for the peptidylglutamyl-peptide hydrolysing (caspase-like) activity of the proteasome which may be stimulated in the presence of Mg2+ ions and rapidly inactivated by N-acetylimidazole

Uses

Z-Leu-Leu-Glu-7-amido-4-methylcoumarin has been used as a fluorogenic substrate for peptidyl glutamyl peptide hydrolase (PGPH) in rat soleus muscle, neonatal cardiomyocytes and rat brain samples.

General Description

Z-Leu-Leu-Glu-7-amido-4-methylcoumarin is a fluoropeptide. It acts as a substrate for caspase-like activity.

Biochem/physiol Actions

Fluorogenic substrate for the measurement of the peptidylglutamyl-peptide hydrolyzing activity of the 20S proteasome.

storage

+4°C

Z-LEU-LEU-GLU-AMC Preparation Products And Raw materials

Raw materials

Preparation Products

Z-LEU-LEU-GLU-AMC Suppliers

Global( 87)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32165 58
Career Henan Chemica Co 		+86-0371-86658258 +8613203830695 laboratory@coreychem.com China 30240 58
BOC Sciences 		16314854226; +16314854226 inquiry@bocsci.com United States 19741 58
Zhejiang J&C Biological Technology Co.,Limited 		+1-2135480471 +1-2135480471 sales@sarms4muscle.com China 10473 58
Nextpeptide Inc 		+86-0571-81612335 +8613336028439 sales@nextpeptide.com China 19908 58
Chengdu Youngshe Chemical Co., Ltd. 		+8618108235634 Cecilia@youngshechem.com China 2345 58
Nanjing TGpeptide 		+86-13347807150 +86-13347807150 support@tgpeptide.com China 3279 58
Zhejiang Hangyu API Co., Ltd 		+8617531972939 anna@api-made.com China 2943 58
Changsha MOL Changes Biotechnology Co., Ltd. 		+8619375158599 info@molchanges.com China 5225 58
DONBOO AMINO ACID COMPANY 		+8613063595538 donboo@donboo.com China 9363 58
Supplier Advantage
TargetMol Chemicals Inc. 		58
Career Henan Chemica Co 		58
BOC Sciences 		58
Zhejiang J&C Biological Technology Co.,Limited 		58
Nextpeptide Inc 		58
Chengdu Youngshe Chemical Co., Ltd. 		58
Nanjing TGpeptide 		58
Zhejiang Hangyu API Co., Ltd 		58
Changsha MOL Changes Biotechnology Co., Ltd. 		58
DONBOO AMINO ACID COMPANY 		58

View Lastest Price from Z-LEU-LEU-GLU-AMC manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Z-LLE-AMC pictures 2024-10-24 Z-LLE-AMC
348086-66-8
 US $588.00-325.00 / mg 10g TargetMol Chemicals Inc.
  • Z-LLE-AMC pictures
  • Z-LLE-AMC
    348086-66-8
  • US $588.00-325.00 / mg
  • TargetMol Chemicals Inc.

348086-66-8(Z-LEU-LEU-GLU-AMC)Related Search:

Z-LEU-LEU-ARG-AMC Z-LEU-ARG-7-AMINO-4-METHYLCOUMARIN Z-LEU-LEU-OH Z-LLL-AMC BENZYLOXYCARBONYL-L-LEUCYL-L-ARGINYLGLYCYLGLYCINE 4-METHYLCOUMARYL-7-AMIDE
H-GLU(AMC)-OH MG-115 Z-LEU-LEU-GLU-AMC Z-LEU-LEU-GLU-7-AMINO-4-TRIFLUOROMETHYLCOUMARIN GLUTAMIC ACID(ANILIDE)-OH

1of2

CBZ-LEU-LEU-GLU-AMC CARBOBENZOXY-L-LEUCYL-L-LEUCYL-L-GLUTAMIC-ACID-ALPHA-(4-METHYLCOUMARINYL)-7-AMIDE BENZYLOXYCARBONYL-L-LEUCYL-L-LEUCYL-L-GLUTAMIC ACID ALPHA-(4-METHYLCOUMARYL-7-AMIDE) PROTEASOME SUBSTRATE II (FLUOROGENIC) Z-LEU-LEU-GLU-7-AMIDO-4-METHYLCOUMARIN Z-LEU-LEU-GLU-7-AMINO-4-METHYLCOUMARIN Z-LEU-LEU-GLU-AMC Z-LEU-LEU-GLU-MCA Z-LLE-AMC Z-ILE-AMC N-[(Phenylmethoxy)carbonyl]-L-leucyl-L-leucyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-L-alpha-glutamine Z-LLG-AMC Cbz-Leu-Leu-Glu-AMC, Z-LLE-AMC (5S,8S,11S)-5,8-Diisobutyl-11-((4-methyl-2-oxo-2H-chromen-7-yl)carbamoyl)-3,6,9-trioxo-1-phenyl-2-oxa-4,7,10-triazatetradecan-14-oic acid Z-LEU-LEU-GLY-AMC benzyloxycarbonyl-L-leucyl-L-leucyl-L-glutamic acid α-(4-methylcoumaryl-7-amide) Proteasome Substrate II L-α-Glutamine, N-[(phenylmethoxy)carbonyl]-L-leucyl-L-leucyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)- 348086-66-8 C35H44N4O9 Proteasome substrate II.