8-pCPT-2-O-Me-cAMP-AM
- CAS No.
- 1152197-23-3
- Chemical Name:
- 8-pCPT-2-O-Me-cAMP-AM
- Synonyms
- 8-pCPT-2-O-Me-cAMP-AM;8 pCPT 2 O Me cAMP AM,8pCPT2OMecAMPAM;8-(4-Chlorophenylthio)-2'-O-methyladenosine 3',5'-(acetyloxy)methyl)-cyclic monophosphate;Adenosine, 8-[(4-chlorophenyl)thio]-2'-O-methyl-, cyclic 3',5'-[(acetyloxy)methyl phosphate]
- CBNumber:
- CB63037111
- Molecular Formula:
- C20H21ClN5O8PS
- Molecular Weight:
- 557.9
- MDL Number:
- MFCD26792583
- MOL File:
- 1152197-23-3.mol
Boiling point | 757.2±70.0 °C(Predicted) |
---|---|
Density | 1.80±0.1 g/cm3(Predicted) |
storage temp. | -20°C |
solubility | Soluble in DMSO (up to 50 mg/ml). |
form | solid |
pka | 2.88±0.10(Predicted) |
color | Colorless to light yellow |
Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month. |
8-pCPT-2-O-Me-cAMP-AM price More Price(3)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | SML3072 | 8-pCPT-2′-O-Me-cAMP-AM ≥98% (HPLC) | 1152197-23-3 | 1UMO | $394 | 2023-06-20 | Buy |
TRC | C781488 | 8-pCPT-2’-O-Me-cAMP-AM | 1152197-23-3 | 100g | $525 | 2021-12-16 | Buy |
ApexBio Technology | B5737 | 8-pCPT-2-O-Me-cAMP-AM | 1152197-23-3 | 100ug | $215 | 2021-12-16 | Buy |
8-pCPT-2-O-Me-cAMP-AM Chemical Properties,Uses,Production
Description
8-pCPT-2-O-Me-cAMP-AM (1152197-23-3) is a potent, cell-permeable Epac (exchange protein directly activated by cAMP) activator.1?Induces RAP1 activation and insulin secretion in pancreatic beta cell lines.2-5?Induces vascular relaxation in rat mesenteric artery.6?The acetoxymethyl ester confers increased cell-permeability and is cleaved by endogenous esterases to yield the active compound, 8-pCPT-2′-O-Me-cAMP. Addition to cell cultures should be done in serum-free media as esterases in serum will cleave the acetoxymethyl ester and reduce cell permeability.
Uses
8-pCPT-2-O-Me-cAMP-AM (cas# 1152197-23-3) is a useful research chemical.8-pCPT-2-O-Me-cAMP-AM was used in the study to discover potential insulin secretagogue properties of an acetoxymethyl that activates guanine nucleotide exchange factors.
storage
Store at -20°C
References
1) Vliem?et al. (2008),?8-pCPT-2′-O-Me-cAMP-AM: an improved Epac-selective cAMP analogue; Chem. Biochem.,?9?2052 2) Chepurny?et al. (2009),?Enhanced Rap1 activation and insulin secretagogue properties of an acetoxymethyl ester of an Epac-selective cyclic AMP analog in rat INS-1 cells: studies with 8-pCPT-2′-O-Me-cAMP-AM; J. Biol. Chem.,?284?10728 3) Kelley?et al. (2009),?Glucose-dependent potentiation of mouse islet insulin secretion by Epac activator 8-pCPT-2′-O-Me-cAMP-AM; Islets,?1?260 4) Chepurny?et al. (2010),?PKA-dependent potentiation of glucose-stimulated insulin secretion by Epac activator 8-pCPT-2′-O-Me-cAMP-AM in human islets of Langerhans; Am. J. Physiol. Endocrinol. Metab.,?298?E622 5) Dzhura?et al. (2011),?Phospholipase C-ε links EPAC2 activation to the potentiation of glucose stimulated insulin secretion from mouse islets of Langerhans; Islets,?3?121 6) Roberts?et al. (2013),?Exchange protein activated by cAMP (Epac) induces vascular relaxation by activating Ca2+-sensitive K+ channels in rat mesenteric artery; J. Physiol.,?591?5107
8-pCPT-2-O-Me-cAMP-AM Preparation Products And Raw materials
Raw materials
Preparation Products
8-pCPT-2-O-Me-cAMP-AM Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
EMMX Biotechnology LLC | 888-539-0666 | info@emmx.com | United States | 8449 | 60 |
BOC Sciences | 16314854226 | inquiry@bocsci.com | United States | 9713 | 58 |
MedBioPharmaceutical Technology Inc | 021-69568360 18916172912 | order@med-bio.cn | China | 8141 | 58 |
TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24648 | 58 |
ApexBio Technology | -- | sales@apexbt.com | United States | 6254 | 58 |
Supplier | Advantage |
---|---|
BOC Sciences | 58 |
TargetMol Chemicals Inc. | 58 |
EMMX Biotechnology LLC | 60 |
BOC Sciences | 58 |
MedBioPharmaceutical Technology Inc | 58 |
TargetMol Chemicals Inc. | 58 |
ApexBio Technology | 58 |