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EPAC 5376753
- CAS No.
- 302826-61-5
- Chemical Name:
- EPAC 5376753
- Synonyms
- EPAC 5376753;4,6(1H,5H)-Pyrimidinedione, 5-[[5-(2,4-dichlorophenyl)-2-furanyl]methylene]dihydro-2-thioxo-
- CBNumber:
- CB38054392
- Molecular Formula:
- C15H8Cl2N2O3S
- Molecular Weight:
- 367.21
- MDL Number:
- MFCD00809401
- MOL File:
- 302826-61-5.mol
Last updated:2023-05-18 11:31:21
| Density | 1.63±0.1 g/cm3(Predicted) |
|---|---|
| storage temp. | -20°C |
| solubility | Soluble in DMSO (up to 15 mg/ml) or in DMF (up to 10 mg/ml) |
| form | solid |
| pka | 4.86±0.20(Predicted) |
| color | Orange-red |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or DMF may be stored at -20°C for up to 3 months. |
EPAC 5376753 Chemical Properties,Uses,Production
Description
EPAC 5376753 (302826-61-5) is an allosteric inhibitor of Epac1, IC50= 4 μM.1 Does not inhibit PKA or adenylyl cyclase. Inhibits biological functions mediated by Epac including cAMP-induced increase in migration of cardiac fibroblasts. A useful tool for probing the role of Epac in cellular physiology and pathophysiology.2
References
1) Brown et al. (2014), Allosteric inhibition of Epac: computational modeling and experimental validation to identify allosteric sites and inhibitors; J. Biol. Chem., 289 29148 2) Parnell et al. (2015), The future of EPAC-targeted therapies: agonism versus antagonism; Trends Pharmacol. Sci., 36 203
EPAC 5376753 Preparation Products And Raw materials
Raw materials
Preparation Products
EPAC 5376753 Suppliers
Global( 5)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 15801484223; | psaitong@jm-bio.com | China | 29778 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24017 | 58 |
| Nanjing Shizhou Biology Technology Co.,Ltd | 025-85560043 15850508050 | cindy.huang@synzest.com | China | 12007 | 58 |
| Supplier | Advantage |
|---|---|
| TargetMol Chemicals Inc. | 58 |
| Beijing Jin Ming Biotechnology Co., Ltd. | 58 |
| TargetMol Chemicals Inc. | 58 |
| Nanjing Shizhou Biology Technology Co.,Ltd | 58 |
302826-61-5(EPAC 5376753)Related Search:
EPAC 5376753
4,6(1H,5H)-Pyrimidinedione, 5-[[5-(2,4-dichlorophenyl)-2-furanyl]methylene]dihydro-2-thioxo-
302826-61-5