SMER18
- CAS No.
- 944153-47-3
- Chemical Name:
- SMER18
- Synonyms
- SMER18;CS-2054;SMER18,SMER-18;Reaxys ID: 18302282;(Z)-1-(4-Chlorophenyl)-3-((3-hydroxyphenyl)amino)but-2-en-1-one;2-Buten-1-one, 1-(4-chlorophenyl)-3-[(3-hydroxyphenyl)amino]-, (2Z)-
- CBNumber:
- CB63041460
- Molecular Formula:
- C16H14ClNO2
- Molecular Weight:
- 287.74
- MDL Number:
- MFCD01571750
- MOL File:
- 944153-47-3.mol
SMER18 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biorbyt Ltd | orb611783 | SMER-18 | 944153-47-3 | 10mg | $615.4 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb611783 | SMER-18 | 944153-47-3 | 50mg | $1802 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb611783 | SMER-18 | 944153-47-3 | 100mg | $2512.6 | 2021-12-16 | Buy |
| Crysdot | CD31000130 | SMER18 98+% | 944153-47-3 | 5mg | $243 | 2021-12-16 | Buy |
| Crysdot | CD31000130 | SMER18 98+% | 944153-47-3 | 10mg | $347 | 2021-12-16 | Buy |
SMER18 Chemical Properties,Uses,Production
Uses
SMER18 is a small molecule enhancer of rapamycin which act as a mTOR-independent autophagy inducer. Target: mTOR SMER18 induces autophagy independently of Rapamycin in mammalian cells, enhancing the clearance of autophagy substrates such as mutant huntingtin and A53T alpha-synuclein, which are associated with Huntington's disease and familial Parkinson's disease, respectively. SMER18 acts either independently or downstream of the target of Rapamycin, attenuates mutant huntingtin-fragment toxicity in Huntington's disease cell and Drosophila melanogaster models, which suggests therapeutic potential.
References
[1] Sarkar S, et al. Small molecules enhance autophagy and reduce toxicity in Huntington's disease models. Nat Chem Biol. 2007 Jun;3(6):331-338. DOI:10.1038/nchembio883
SMER18 Preparation Products And Raw materials
Raw materials
Preparation Products
SMER18 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32202 | 58 |
| Haoyuan Chemexpress Co., Ltd. | 021-58950125 | info@chemexpress.com | China | 7552 | 61 |
| MedChemexpress LLC | 021-58955995 | sales@medchemexpress.cn | United States | 4861 | 58 |
| Shanghai Chaolan Chemical Technology Center | 021-QQ：65489617 15618227136 | Sales@ATKchemical.com | China | 9330 | 58 |
| Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 18892239720 | psaitong@jm-bio.com | China | 12306 | 58 |
| Musechem | +1-800-259-7612 | info@musechem.com | United States | 4660 | 60 |
| Shenzhen Regent Biochemical Technology Co., Ltd. | 0755-85201366 18938635012 | sales@regentsciences.com | China | 9456 | 58 |
| Fan De(Beijing) Biotechnology Co., Ltd. | 15911056312 | liming@bio-fount.com | China | 9729 | 58 |
| DC Chemicals | 021-58447131 13564518121 | sales@dcchemicals.com | China | 9409 | 58 |
| Cckinase, Inc. | +1 (732)236-3202 | sales@cckinase.com | United States | 2738 | 58 |
