GSK1059865
- CAS No.
- 1191044-58-2
- Chemical Name:
- GSK1059865
- Synonyms
- GSK1059865;GSK1059865 HCl;GSK-1059865 (GSK 1059865;Methanone, [(2S,5S)-2-[[(5-bromo-2-pyridinyl)amino]methyl]-5-methyl-1-piperidinyl](3-fluoro-2-methoxyphenyl)-
- CBNumber:
- CB63067549
- Molecular Formula:
- C20H23BrFN3O2
- Molecular Weight:
- 436.32
- MDL Number:
- MFCD31618413
- MOL File:
- 1191044-58-2.mol
GSK1059865 price
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
ChemScene | CS-7915 | GSK1059865 99.55% | 1191044-58-2 | 5mg | $192 | 2021-12-16 | Buy |
ChemScene | CS-7915 | GSK1059865 99.55% | 1191044-58-2 | 10mg | $324 | 2021-12-16 | Buy |
AK Scientific | SYN5019 | GSK1059865 | 1191044-58-2 | 10mg | $335 | 2021-12-16 | Buy |
ChemScene | CS-7915 | GSK1059865 99.55% | 1191044-58-2 | 25mg | $684 | 2021-12-16 | Buy |
ChemScene | CS-7915 | GSK1059865 99.55% | 1191044-58-2 | 50mg | $1152 | 2021-12-16 | Buy |
GSK1059865 Chemical Properties,Uses,Production
Biological Activity
GSK1059865 is a potent orexin 1 receptor antagonist.
in vivo
Treatment with GSK1059865 significantly decreases ethanol drinking in a dose-dependent manner in CIE-exposed mice. In contrast GSK1059865 decreases drinking in air-exposed mice only at the highest dose used. There is no effect of GSK1059865 on sucrose intake. GSK1059865 (0.3 nM-10 nM) produces non-surmountable antagonism with a dose-dependent rightward shift of the OXA EC 50 and a concomitant decrease of the agonist maximal response. The calculated pK B value is 8.77±0.12 for GSK1059865. GSK1059865 (0.1-3.3 μM) produces a classical surmountable profile with parallel rightward shift of the OXA EC 50 without depression of the agonist maximal response. Intraperitoneal The administration of GSK1059865 produces a region-dependent inhibition of yohimbine-induced relative cerebral blood volume response. The administration of GSK1059865 per se produces a weak relative cerebral blood volume increase in several brain regions. GSK1059865-pretreated ani mals exhibit slightly higher baseline mean arterial blood pressure values than controls.
target
Orexin 1 receptor
GSK1059865 Preparation Products And Raw materials
Raw materials
Preparation Products
GSK1059865 Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd | +86-18341751992 +86-15382112998 | 757984502@qq.com | China | 892 | 58 |
Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
Pharmacodia (Beijing) Co.,Ltd | +86-400-851-9921 | sales@pharmacodia.com | China | 2317 | 55 |
Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9707 | 58 |
Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131980 | 58 |
Lynnchem | 86-(0)29-85992781 17792393971 | info@lynnchem.com | China | 4587 | 58 |
Novachemistry | 44-20819178-90 02081917890 | info@novachemistry.com | United Kingdom | 4381 | 58 |
Fan De(Beijing) Biotechnology Co., Ltd. | 15911056312 | liming@bio-fount.com | China | 9730 | 58 |