1191044-58-2
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- CAS号:
- 1191044-58-2
- 英文名:
- GSK1059865
- 英文别名:
- GSK1059865;GSK1059865 HCl;GSK-1059865
(GSK 1059865;Methanone, [(2S,5S)-2-[[(5-bromo-2-pyridinyl)amino]methyl]-5-methyl-1-piperidinyl](3-fluoro-2-methoxyphenyl)-
- 中文名:
- 1191044-58-2
- 中文别名:
- 化合物 T11477
- CBNumber:
- CB63067549
- 分子式:
- C20H23BrFN3O2
- 分子量:
- 436.32
- MOL File:
- 1191044-58-2.mol
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1191044-58-2化学性质
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沸点:
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575.8±50.0 °C(Predicted)
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密度:
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1.376±0.06 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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DMSO : ≥ 50 mg/mL (114.59 mM)
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形态:
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Solid
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酸度系数(pKa):
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4.89±0.10(Predicted)
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颜色:
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White to off-white
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1191044-58-2性质、用途与生产工艺
GSK1059865是有效地食欲素1受体 (orexin 1 receptor) 拮抗剂。
Treatment with GSK1059865 significantly decreases ethanol drinking in a dose-dependent manner in CIE-exposed mice. In contrast GSK1059865 decreases drinking in air-exposed mice only at the highest dose used. There is no effect of GSK1059865 on sucrose intake. GSK1059865 (0.3 nM-10 nM) produces non-surmountable antagonism with a dose-dependent rightward shift of the OXA EC
50
and a concomitant decrease of the agonist maximal response. The calculated pK
B
value is 8.77±0.12 for GSK1059865. GSK1059865 (0.1-3.3 μM) produces a classical surmountable profile with parallel rightward shift of the OXA EC
50
without depression of the agonist maximal response. Intraperitoneal administration of GSK1059865 produces a region-dependent inhibition of yohimbine-induced relative cerebral blood volume response. The administration of GSK1059865 per se produces a weak relative cerebral blood volume increase in several brain regions. GSK1059865-pretreated animals exhibit slightly higher baseline mean arterial blood pressure values than controls.
1191044-58-2
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更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/08/19 | HY-101534 | 1191044-58-2 GSK1059865 | 1191044-58-2 | 5mg | 1950元 |
2024/08/19 | HY-101534 | 1191044-58-2 GSK1059865 | 1191044-58-2 | 10mM * 1mLin DMSO | 2150元 |
1191044-58-2, 1191044-58-2 相关搜索:
- C20H23BrFN3O2
- 化合物 T11477
- 1191044-58-2
- GSK1059865 HCl
- Methanone, [(2S,5S)-2-[[(5-bromo-2-pyridinyl)amino]methyl]-5-methyl-1-piperidinyl](3-fluoro-2-methoxyphenyl)-
- GSK-1059865
(GSK 1059865
- GSK1059865