ChemicalBook >> CAS DataBase List >>6-(1H-indol-4-yl)-4-(5-((4-isopropylpiperazin-1-yl)methyl)oxazol-2-yl)-1H-indazole
6-(1H-indol-4-yl)-4-(5-((4-isopropylpiperazin-1-yl)methyl)oxazol-2-yl)-1H-indazole
- CAS No.
- 1254036-71-9
- Chemical Name:
- 6-(1H-indol-4-yl)-4-(5-((4-isopropylpiperazin-1-yl)methyl)oxazol-2-yl)-1H-indazole
- Synonyms
- CS-2340;Nemiralisib;GSK2269557 (free base);Nemiralisib(GSK2269557);gsk2269557(Nemiralisib);GSK 2269557;GSK-2269557;PI3Kδ inhibitor GS2269557;PI3Kδ inhibitor GS2269557;Nemiralisib (GSK2269557 free base);6-(1H-indol-4-yl)-4-(5-((4-isopropylpiperazin-1-yl)methyl)oxazol-2-yl)-1H-indazole
- CBNumber:
- CB63106826
- Molecular Formula:
- C26H28N6O
- Molecular Weight:
- 440.54
- MDL Number:
- MFCD28128611
- MOL File:
- 1254036-71-9.mol
Last updated:2024-07-02 08:55:13
Boiling point | 706.2±70.0 °C(Predicted) |
---|---|
Density | 1.281±0.06 g/cm3(Predicted) |
storage temp. | Store at -20°C |
solubility | DMSO: 33.33 mg/mL (75.66 mM) |
form | Solid |
pka | 12.90±0.40(Predicted) |
color | White to yellow |
FDA UNII | OEP8JJ3OZR |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
---|---|
Signal word | Warning |
Hazard statements | H302-H315-H319-H335 |
Precautionary statements | P261-P305+P351+P338 |
6-(1H-indol-4-yl)-4-(5-((4-isopropylpiperazin-1-yl)methyl)oxazol-2-yl)-1H-indazole price
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
ChemScene | CS-5683 | Nemiralisib 99.50% | 1254036-71-9 | 1mg | $84 | 2021-12-16 | Buy |
ChemScene | CS-5683 | Nemiralisib 99.50% | 1254036-71-9 | 5mg | $144 | 2021-12-16 | Buy |
ChemScene | CS-5683 | Nemiralisib 99.50% | 1254036-71-9 | 10mg | $228 | 2021-12-16 | Buy |
Matrix Scientific | 148001 | 1H-Indazole | 1254036-71-9 | 5mg | $482 | 2021-12-16 | Buy |
ChemScene | CS-5683 | Nemiralisib 99.50% | 1254036-71-9 | 25mg | $492 | 2021-12-16 | Buy |
6-(1H-indol-4-yl)-4-(5-((4-isopropylpiperazin-1-yl)methyl)oxazol-2-yl)-1H-indazole Chemical Properties,Uses,Production
Biological Activity
Nemiralisib, also known as GSK-2269557, is a potent and selective PI3Kδ inhibitor (pKi=9.9).
in vivo
Nemiralisib has relatively low oral bioavailability (F=2%), in vivo clearance is 28 mL/min/kg, but high volume distribution, 6.3 L/kg. 0.3-1 μMGSK-2269557 induction concentration Dependent QT interval and Tpe prolongation, 1 μM GSK-2269557 resulted in prolongation of the ORS wave, during which no torsades de pointes arrhythmia was observed.
target
Target | Value |
PI3Kδ (Cell-free assay) | 9.9(pKi) |
6-(1H-indol-4-yl)-4-(5-((4-isopropylpiperazin-1-yl)methyl)oxazol-2-yl)-1H-indazole Preparation Products And Raw materials
Raw materials
Preparation Products
6-(1H-indol-4-yl)-4-(5-((4-isopropylpiperazin-1-yl)methyl)oxazol-2-yl)-1H-indazole Suppliers
Global( 41)Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10522 | 58 |
InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
Hebei Miaoyin Technology Co.,Ltd | +86-17367732028 +86-17367732028 | kathy@hbyinsheng.com | China | 3581 | 58 |
Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131980 | 58 |
Dalian Meilun Biotech Co., Ltd. | 0411-62910999 13889544652 | meilunui@163.com | China | 4672 | 58 |
MedChemexpress LLC | 021-58955995 | sales@medchemexpress.cn | United States | 4863 | 58 |
Shanghai Beckham Medical Technology Co., Ltd | 021-13816613772 13816613772 | huahero21@sina.com | China | 408 | 55 |
6-(1H-indol-4-yl)-4-(5-((4-isopropylpiperazin-1-yl)methyl)oxazol-2-yl)-1H-indazole
GSK2269557 (free base)
1H-Indazole, 6-(1H-indol-4-yl)-4-[5-[[4-(1-methylethyl)-1-piperazinyl]methyl]-2-oxazolyl]-
PI3Kδ inhibitor GS2269557
CS-2340
gsk2269557(Nemiralisib)
Nemiralisib(GSK2269557)
Nemiralisib (GSK2269557 free base)
GSK 2269557;GSK-2269557
Nemiralisib
PI3Kδ inhibitor GS2269557
2-(6-(1H-Indol-4-yl)-1H-indazol-4-yl)-5-((4-isopropylpiperazin-1-yl)methyl)oxazole
1254036-71-9
C26H28N6O