XE 991 dihydrochloride
- CAS No.
- 122955-13-9
- Chemical Name:
- XE 991 dihydrochloride
- Synonyms
- XE 991 HCl;XE991 HCl (LS190926);XE 991 (hydrochloride);10,10-bis(pyridin-4-ylmethyl)anthracen-9-one;10,10-bis(pyridin-4-ylmethyl)anthracen-9-one:dihydrochloride;10,10-Bis(pyridin-4-ylmethyl)anthracen-9(10H)-one dihydrochloride;XE991,inhibit,XE 991 dihydrochloride,KcsA,XE 991,XE-991,Inhibitor,Potassium Channel
- CBNumber:
- CB63146404
- Molecular Formula:
- C26H21ClN2O
- Molecular Weight:
- 412.92
- MDL Number:
- MFCD09055426
- MOL File:
- 122955-13-9.mol
- MSDS File:
- SDS
XE 991 dihydrochloride price More Price(14)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 14582 | XE 991 (hydrochloride) ≥99% | 122955-13-9 | 5mg | $62 | 2024-03-01 | Buy |
| Cayman Chemical | 14582 | XE 991 (hydrochloride) ≥99% | 122955-13-9 | 10mg | $115 | 2024-03-01 | Buy |
| Cayman Chemical | 14582 | XE 991 (hydrochloride) ≥99% | 122955-13-9 | 50mg | $477 | 2024-03-01 | Buy |
| TRC | X750935 | XE991Dihydrochloride | 122955-13-9 | 100mg | $625 | 2021-12-16 | Buy |
| ChemScene | CS-0029210 | XE991dihydrochloride 98.44% | 122955-13-9 | 5mg | $150 | 2021-12-16 | Buy |
XE 991 dihydrochloride Chemical Properties,Uses,Production
Description
The KCNQ potassium channels are neuronal modulators which combine with other KQT or KCNE channels to form heteromultimers. XE 991 is a blocker of KCNQ channels that potently inhibits KCNQ1 and 2 homomeric channels (IC50 = 0.75 and 0.71 μM, respectively) as well as KCNQ2+3 heteromultimers (IC50 = 0.6 μM). It much less effectively blocks eag, erg, and elk channels. The effectiveness of XE 991 against KCNQ channels depends on partners or accessory proteins. Through these actions, XE 991 enhances acetylcholine release from rat brain slices (EC50 = 490 nM) and shows good in vivo potency and duration of action, suggesting utility in Alzheimer’s disease therapeutics. While early studies focused on actions in the central nervous system, XE 991 can be used to explore the roles of KCNQ channels in neuronal regulation throughout the body.
Uses
XE 991 dihydrochloride is a potent & selective inhibitor of KCNQ voltage-gated K-channels.
storage
Desiccate at RT
XE 991 dihydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
XE 991 dihydrochloride Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32957 | 60 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32165 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6312 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49734 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 57505 | 58 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4512 | 55 | |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9806 | 58 |
| ShangHai Biochempartner Co.,Ltd | 177-54423994 17754423994 | 2853530910@QQ.com | China | 8011 | 62 |
| Shanghai SuperLan Chemcial Technique Centre | 021-2022843681 15618226720 | lucy@atkchemical.com | China | 10267 | 58 |