ChemicalBook >제품 카탈로그 >XE 991 dihydrochloride

XE 991 dihydrochloride

XE 991 dihydrochloride 구조식 이미지

카스 번호:: 122955-13-9

상품명:: XE 991 dihydrochloride

동의어(영문):: XE 991 HCl;XE991 HCl (LS190926);XE 991 (hydrochloride);10,10-bis(pyridin-4-ylmethyl)anthracen-9-one;10,10-bis(pyridin-4-ylmethyl)anthracen-9-one:dihydrochloride;10,10-Bis(pyridin-4-ylmethyl)anthracen-9(10H)-one dihydrochloride;XE991,inhibit,XE 991 dihydrochloride,KcsA,XE 991,XE-991,Inhibitor,Potassium Channel

CBNumber:: CB63146404

분자식:: C26H21ClN2O

포뮬러 무게:: 412.92

MOL 파일:: 122955-13-9.mol

속성

안전

용도

공급 업체 44

XE 991 dihydrochloride 속성

저장 조건: Store at -20°C

용해도: DMF:PBS(pH 7.2)(1:1): 0.5 mg/mL; DMSO: 2 mg/mL

물리적 상태: 가루

색상: Off-white to light yellow

수용성: 물에 100mM까지 용해됨

안전

XE 991 dihydrochloride C화학적 특성, 용도, 생산

개요

The KCNQ potassium channels are neuronal modulators which combine with other KQT or KCNE channels to form heteromultimers. XE 991 is a blocker of KCNQ channels that potently inhibits KCNQ1 and 2 homomeric channels (IC₅₀ = 0.75 and 0.71 μM, respectively) as well as KCNQ2+3 heteromultimers (IC₅₀ = 0.6 μM). It much less effectively blocks eag, erg, and elk channels. The effectiveness of XE 991 against KCNQ channels depends on partners or accessory proteins. Through these actions, XE 991 enhances acetylcholine release from rat brain slices (EC₅₀ = 490 nM) and shows good in vivo potency and duration of action, suggesting utility in Alzheimer’s disease therapeutics. While early studies focused on actions in the central nervous system, XE 991 can be used to explore the roles of KCNQ channels in neuronal regulation throughout the body.

용도

XE 991 dihydrochloride is a potent & selective inhibitor of KCNQ voltage-gated K-channels.

XE 991 dihydrochloride 준비 용품 및 원자재

원자재

준비 용품

XE 991 dihydrochloride 공급 업체

글로벌( 44)공급 업체

공급자	전화	이메일	국가	제품 수	이점
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32760	60
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	86-571-88216897,88216896 13588875226	sales@hzclap.com	CHINA	6313	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6393	58
Hangzhou MolCore BioPharmatech Co.,Ltd.	+86-057181025280; +8617767106207	sales@molcore.com	China	49739	58
Aladdin Scientific	+1-+1(833)-552-7181	sales@aladdinsci.com	United States	57511	58
Shanghai Lollane Biological Technology Co.,Ltd.	021-52996696，15000506266 15000506266		China	4252	55
Shanghai EFE Biological Technology Co., Ltd.	021-65675885 18964387627	info@efebio.com	China	9707	58
ShangHai Biochempartner Co.,Ltd	17754423994 17754423994	2853530910@QQ.com	China	8011	62
Shanghai Chaolan Chemical Technology Center	QQ:65489617 15618227136	info@SuperLan-chem.com	China	9874	58

XE 991 dihydrochloride 관련 검색:

XEN445