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GSK484

GSK484 structure

CAS No.: 1652591-81-5

Chemical Name:: GSK484

Synonyms: GSK484;CS-2265;AOB6992;GTPL8577;GSK484 HCl;GSK484 >=98% (HPLC);PAD4 inhibitor GS484;PAD4 inhibitor GSK484;GSK484 (hydrochloride);GSK484, PAD4 inhibitor

CBNumber:: CB63146499

Molecular Formula:: C27H32ClN5O3

Molecular Weight:: 510.04

MDL Number:

MOL File:: 1652591-81-5.mol

Last updated:2024-11-18 17:43:10

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GSK484 Properties

storage temp.	2-8°C
solubility	DMSO:25.0(Max Conc. mg/mL);49.01(Max Conc. mM) Ethanol:25.0(Max Conc. mg/mL);49.01(Max Conc. mM) PBS buffer (pH 7.2):5.0(Max Conc. mg/mL);9.8(Max Conc. mM) DMF:30.0(Max Conc. mg/mL);58.82(Max Conc. mM)
form	powder
color	white to beige
InChIKey	MULKOGJHUZTANI-JEGYXLSDNA-N
SMILES	C(C1CC1)N1C2=CC=CC=C2C=C1C1=NC2=CC(C(N3CC[C@@H](O)[C@@H](N)C3)=O)=CC(OC)=C2N1C.Cl \|&1:22,24,r\|

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P261-P305+P351+P338
HS Code	2933399990

GSK484 price More Price(21)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	SML1658	GSK484 ≥98% (HPLC)	1652591-81-5	5MG	$346	2023-06-20	Buy
Sigma-Aldrich	SML1658	GSK484 ≥98% (HPLC)	1652591-81-5	25MG	$1350	2023-06-20	Buy
Cayman Chemical	17488	GSK484 (hydrochloride) ≥95%	1652591-81-5	500μg	$37	2024-03-01	Buy
Cayman Chemical	17488	GSK484 (hydrochloride) ≥95%	1652591-81-5	1mg	$68	2024-03-01	Buy
Cayman Chemical	17488	GSK484 (hydrochloride) ≥95%	1652591-81-5	5mg	$283	2024-03-01	Buy

Product number	Packaging	Price	Buy
SML1658	5MG	$346	Buy
SML1658	25MG	$1350	Buy
17488	500μg	$37	Buy
17488	1mg	$68	Buy
17488	5mg	$283	Buy

GSK484 Chemical Properties,Uses,Production

Description

GSK484 is a reversible inhibitor of PAD4 (IC₅₀ = 50 nM) that binds to the low-calcium form of the enzyme. It is selective for PAD4 over PAD1-3. GSK484 blocks the citrullination of PAD4 target proteins in human neutrophils and inhibits the formation of neutrophil extracellular traps in both mouse and human neutrophils. It exhibits favorable pharmacokinetic profiles in mouse and rat. See the Structural Genomics Consortium (SGC) website for more information.

Uses

GSK484 is a novel selective PAD4 inhibitor.

Biochem/physiol Actions

GSK484 is a potent selective reversible inhibitor of protein arginine deiminase PAD4, an enzyme believed to play a role in granulocyte and macrophage development leading to inflammation and immune response, and overexpressed in many tumors. GSK484 has IC50 values of 50 nM without calcium and 250 nM in the presence of 2 mM calcium. GSK484 showed minimal off-target activity tested against 50 other proteins with no activation across HDACs 1–11 even at 100 μM. GSK484 binds at a different site from the amidines, a conformation of the PAD4 active site where part of the site is reordered to form a β-hairpin.

GSK484 Preparation Products And Raw materials

Raw materials

Preparation Products

GSK484 Suppliers

Global( 94)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hubei Chuchang Biotech Co., Ltd.	+undefined15623860702	info@chuchangbiotech.com	China	203	58
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32956	60
Career Henan Chemica Co	+86-0371-86658258 +8613203830695	laboratory@coreychem.com	China	30237	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	sales@sarms4muscle.com	China	10473	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6391	58
LEAP CHEM CO., LTD.	+86-852-30606658	market18@leapchem.com	China	24727	58
Nantong HI-FUTURE Biology Co., Ltd.	+undefined18051384581	sales@chemhifuture.com	China	3135	58
TargetMol Chemicals Inc.		support@targetmol.com	United States	38631	58
Hebei Miaoyin Technology Co.,Ltd	+86-17367732028 +86-17367732028	kathy@hbyinsheng.com	China	3512	58
Wuhan Topule Biopharmaceutical Co., Ltd	+8618327326525	masar@topule.com	China	8467	58

Supplier	Advantage
Hubei Chuchang Biotech Co., Ltd.	58
ATK CHEMICAL COMPANY LIMITED	60
Career Henan Chemica Co	58
Zhejiang J&C Biological Technology Co.,Limited	58
InvivoChem	58
LEAP CHEM CO., LTD.	58
Nantong HI-FUTURE Biology Co., Ltd.	58
TargetMol Chemicals Inc.	58
Hebei Miaoyin Technology Co.,Ltd	58
Wuhan Topule Biopharmaceutical Co., Ltd	58

View Lastest Price from GSK484 manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2024-11-19	GSK484 (hydrochloride) 1652591-81-5	US $0.00-0.00 / mg	1mg	98%	100G	Hubei Chuchang Biotech Co., Ltd.
	2024-11-18	GSK484 hydrochloride 1652591-81-5	US $68.00-239.00 / mg		99.62%	10g	TargetMol Chemicals Inc.

GSK484 (hydrochloride)
1652591-81-5
US $0.00-0.00 / mg
98%
Hubei Chuchang Biotech Co., Ltd.

GSK484 hydrochloride
1652591-81-5
US $68.00-239.00 / mg
99.62%
TargetMol Chemicals Inc.

1652591-81-5(GSK484)Related Search:

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GSK-3326595 GSK864 S)-1-(sec-butyl)-N-((4,6-diMethyl-2-oxo-1,2-dihydropyridin-3-yl)Methyl)-3-Methyl-6-(6-(piperazin-1-yl)pyridin-3-yl)-1H-indole-4-carboxaMide

1of4

GSK484 GSK484 (hydrochloride) CS-2265 PAD4 inhibitor GS484 GSK484 HCl ((3S,4R)-3-amino-4-hydroxypiperidin-1-yl)(2-(1-(cyclopropylmethyl)-1H-indol-2-yl)-7-methoxy-1-methyl-1H-benzo[d]imidazol-5-yl)methanone hydrochloride AOB6992 GTPL8577 GSK484 >=98% (HPLC) PAD4 inhibitor GSK484 GSK484 hydrochloride,GSK 484,Protein Arginine Deiminase,GSK-484,GSK-484 hydrochloride,GSK484,inhibit,Peptidylarginine Deiminase,Inhibitor ((3S,4R)-3-Amino-4-hydroxypiperidin-1-yl)(2-(1-(cyclopropylmethyl)-1H-indol-2-yl)-7-methoxy-1-methyl-1H-benzo[d]imidazol-5-yl)methanone hydrochloride , GSK484 HCl GSK484, PAD4 inhibitor 1652591-81-5 652591-81-5 C27H31N5O3ClH