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PKCζ Pseudosubstrate Inhibitor

CAS No.
799764-07-1
Chemical Name:
PKCζ Pseudosubstrate Inhibitor
Synonyms
Pseudosubstrate Inhibitor;PKCζ Pseudosubstrate Inhibitor;PKC.zeta. Pseudosubstrate Inhibitor;PKCζ Pseudosubstrate Inhibitor (Protein Kinase Cζ Pseudosubstrate Inhibitor);L-Leucine, L-seryl-L-isoleucyl-L-tyrosyl-L-arginyl-L-arginylglycyl-L-alanyl-L-arginyl-L-arginyl-L-tryptophyl-L-arginyl-L-lysyl-
CBNumber:
CB63152717
Molecular Formula:
C76H128N30O16
Molecular Weight:
1718.02
MDL Number:
MOL File:
799764-07-1.mol
Last updated:2023-04-23 13:52:06

PKCζ Pseudosubstrate Inhibitor Properties

Density 1.48±0.1 g/cm3(Predicted)
solubility DMF: 20 mg/ml; DMSO: 30 mg/ml; PBS (pH 7.2): 10 mg/ml
form A crystalline solid

PKCζ Pseudosubstrate Inhibitor price More Price(3)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 17482 PKCζ Pseudosubstrate Inhibitor ≥95% 799764-07-1 500μg $96 2024-03-01 Buy
Cayman Chemical 17482 PKCζ Pseudosubstrate Inhibitor ≥95% 799764-07-1 1mg $182 2024-03-01 Buy
Cayman Chemical 17482 PKCζ Pseudosubstrate Inhibitor ≥95% 799764-07-1 5mg $758 2024-03-01 Buy
Product number Packaging Price Buy
17482 500μg $96 Buy
17482 1mg $182 Buy
17482 5mg $758 Buy

PKCζ Pseudosubstrate Inhibitor Chemical Properties,Uses,Production

Description

The atypical protein kinase C isoform, PKCζ, is critical for mediating mitogenic signal transduction, cell survival, and some of the physiological actions of insulin.1 PKCζ pseudosubstrate inhibitor is a synthetic peptide that corresponds to a pseudosubstrate domain of this PKC isoform.2 It selectively, reversibly, and substrate-competitively inhibits PKCζ activity and, thus, is used to delineate the signaling functions of PKCζ.3,4,5

References

1. Toker, A. Signaling through protein kinase C Front. Biosci. 3,d1134-d1147(1998).
2. Eichholtz, T., de Bont, D.B.A., de Widt, J., et al. A myristoylated pseudosubstrate peptide, a novel protein kinase C inhibitor J. Biol. Chem. 268(3),1982-1986(1993).
3. Lee, A.W. The role of atypical protein kinase C in CSF-1-dependent Erk activation and proliferation in myeloid progenitors and macrophages PLoS One 6(10),e25580(2011).
4. Dang, P.M.C., Fontayne, A., Hakim, J., et al. Protein kinase C ζ phosphorylates a subset of selective sites of the NADPH oxidase component p47phox and participates in formyl peptide-mediated neutrophil respiratory burst J. Immunol. 166,1206-1213(2001).
5. Standaert, M.L., Galloway, L., Karnam, P., et al. Protein kinase C-ζ as a downstream effector of phosphatidylinositol 3-kinase during insulin stimulation in rat adipocytes. Potential role in glucose transport J. Biol. Chem. 272(48),30075-30082(1997).

PKCζ Pseudosubstrate Inhibitor Preparation Products And Raw materials

Raw materials

Preparation Products

PKCζ Pseudosubstrate Inhibitor Suppliers

Global( 13)Suppliers
Supplier Tel Email Country ProdList Advantage
Shanghai Hongye Biotechnology Co. Ltd 400-9205774 sales@glpbio.cn China 6870 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767 sales@chemegen.com China 11289 58
JiangSu Star Science Co.,Ltd 400-605-7200 17312445705 sales022@b2star.com China 3764 58
Shanghai Maclean Biochemical Technology Co., LTD 021-50706066 15221275939 shenlinxing@macklin.cn China 29803 58
Shanghai HongTide Biotechnology Co.,Ltd. 19961912513 sales@hongtide.com China 4584 58
Shanghai Yifei Biotechnology Co. , Ltd. 021-65675885 18964387627 customer_service@efebio.com China 8739 58
TargetMol Chemicals Inc. 15002134094 marketing@targetmol.cn China 28091 58
PKCζ Pseudosubstrate Inhibitor PKC.zeta. Pseudosubstrate Inhibitor Pseudosubstrate Inhibitor PKCζ Pseudosubstrate Inhibitor (Protein Kinase Cζ Pseudosubstrate Inhibitor) L-Leucine, L-seryl-L-isoleucyl-L-tyrosyl-L-arginyl-L-arginylglycyl-L-alanyl-L-arginyl-L-arginyl-L-tryptophyl-L-arginyl-L-lysyl- 799764-07-1