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INCB28060 Dihydrochloride

CAS No.
1197376-85-4
Chemical Name:
INCB28060 Dihydrochloride
Synonyms
INC-280 2HCl;INCB28060 2HCl;Capmatinib 2HCl;INCB28060 Dihydrochloride;Capmatinib Dihydrochloride;2-Fluoro-N-methyl-4-[7-[(quinolin-6-yl)methyl]imidazo[1,2-b]-[1,2,4]triazin-2-yl]benzamide Dihydrochloride;Benzamide, 2-fluoro-N-methyl-4-[7-(6-quinolinylmethyl)imidazo[1,2-b][1,2,4]triazin-2-yl]-, hydrochloride (1:2);Capmatinib,Apoptosis,c-Met/HGFR,INC 280,H441,INCB28060,INC280,orally active,Capmatinib 2HCl,INCB-28060,SNU-5,INC-280,Inhibitor,S114,INCB 28060,inhibit,U-87MG,ATP competitive,Balb/c nu/nu mice
CBNumber:
CB63167063
Molecular Formula:
C23H18ClFN6O
Molecular Weight:
448.89
MDL Number:
MFCD30502991
MOL File:
1197376-85-4.mol
Last updated:2024-11-19 15:53:33

INCB28060 Dihydrochloride Properties

FDA UNII Z0V2EW20JR

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS08
Signal word  Warning
Hazard statements  H371
Precautionary statements  P260-P264-P270-P309+P311-P405-P501

INCB28060 Dihydrochloride Chemical Properties,Uses,Production

Description

INCB28060 Dihydrochloride is a novel, ATP-competitive inhibitor of c-MET kinase with an IC50 with 0.13 nM.

Uses

INCB28060 dihydrochloride exhibits picomolar enzymatic potency and is highly specific for c-MET with more than 10, 000-fold selectivity over a large panel of human kinases. This inhibitor potently blocks c-MET phosphorylation and activation of its key downstream effectors in c-MET-dependent tumor cell lines. As a result, INCB 28060 potently inhibits c-MET-dependent tumor cell proliferation and migration and effectively induces apoptosis in vitro.

INCB28060 Dihydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 62)Suppliers
Supplier Tel Email Country ProdList Advantage
Shanghai Arbor Chemical Co., Ltd.
021-60451682 act@arborchemical.com CHINA 904 58
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32161 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD
86-571-88216897,88216896 13588875226 sales@hzclap.com CHINA 6312 58
ANHUI WITOP BIOTECH CO., LTD
+8615255079626 eric@witopchemical.com China 23541 58
Hangzhou Cherry Pharmaceutical Technology Co.,ltd
0571-81636070 info@cherrypharmatech.com CHINA 274 58
TargetMol Chemicals Inc.
support@targetmol.com United States 38631 58
Nanjing Fred Technology Co., Ltd
+86-25-84696168 +86-15380713688 Austin@fredbio.com China 2428 58
Wuhan Jingkang en Biomedical Technology Co., Ltd
+8613720134139 orders@jknbiochem.com China 5221 58
Amadis Chemical Company Limited
571-89925085 sales@amadischem.com China 131957 58
Anqing Benro pharmachem Technology Co.,Ltd. 05565209906 15391842992 794263564@qq.com China 116 58

Related articles

View Lastest Price from INCB28060 Dihydrochloride manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Capmatinib 2HCl pictures 2024-11-19 Capmatinib 2HCl
1197376-85-4
US $37.00-64.00 / mg 100% 10g TargetMol Chemicals Inc.
  • Capmatinib 2HCl pictures
  • Capmatinib 2HCl
    1197376-85-4
  • US $37.00-64.00 / mg
  • 100%
  • TargetMol Chemicals Inc.
2-Fluoro-N-methyl-4-[7-[(quinolin-6-yl)methyl]imidazo[1,2-b]-[1,2,4]triazin-2-yl]benzamide Dihydrochloride INCB28060 2HCl INCB28060 Dihydrochloride Capmatinib 2HCl INC-280 2HCl Capmatinib Dihydrochloride Benzamide, 2-fluoro-N-methyl-4-[7-(6-quinolinylmethyl)imidazo[1,2-b][1,2,4]triazin-2-yl]-, hydrochloride (1:2) Capmatinib,Apoptosis,c-Met/HGFR,INC 280,H441,INCB28060,INC280,orally active,Capmatinib 2HCl,INCB-28060,SNU-5,INC-280,Inhibitor,S114,INCB 28060,inhibit,U-87MG,ATP competitive,Balb/c nu/nu mice 1197376-85-4 API API