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CCT251455

CCT251455 Structure
CCT251455 structure
CAS No.
1400284-80-1
Chemical Name:
CCT251455
Synonyms
CCT251455;CCT251455,CCT-251455;BXKNUXDLZJPPBO-UHFFFAOYSA-N;1H-Pyrrolo[3,2-c]pyridine-1-carboxylic acid, 6-[[2-chloro-4-(1-methyl-1H-imidazol-5-yl)phenyl]amino]-2-(1-methyl-1H-pyrazol-4-yl)-, 1,1-dimethylethyl ester
CBNumber:
CB63339864
Molecular Formula:
C26H26ClN7O2
Molecular Weight:
503.98
MDL Number:
MFCD28399124
MOL File:
1400284-80-1.mol
Last updated:2024-07-02 08:55:14
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CCT251455 Properties

Boiling point 731.0±70.0 °C(Predicted)
Density 1.34±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility Soluble in DMSO
form Solid
pka 7.86±0.30(Predicted)
color Light yellow to brown

CCT251455 Chemical Properties,Uses,Production

Description

CCT251455 is a potent and selecltive MSP1 inhibitor with potential anticancer activitiy. The protein kinase MPS1 is a crucial component of the spindle assembly checkpoint signal and is aberrantly overexpressed in many human cancers. MPS1 is one of the top 25 genes overexpressed in tumors with chromosomal instability and aneuploidy. PTEN-deficient breast tumor cells are particularly dependent upon MPS1 for their survival, making it a target of significant interest in oncology. CCT251455 stabilizes an inactive conformation of MPS1 with the activation loop ordered in a manner incompatible with ATP and substrate-peptide binding; it displays a favorable oral pharmacokinetic profile, shows dose-dependent inhibition of MPS1 in an HCT116 human tumor xenograft model, and is an attractive tool compound to elucidate further the therapeutic potential of MPS1 inhibition.

CCT251455 synthesis

1400287-23-1
1400286-74-9
1400284-80-1
Synthesis of CCT251455 from 2-chloro-4-(1-methyl-1H-imidazol-5-yl)aniline and t-butyl 6-bromo-2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridine-1-carboxylate

CCT251455 Preparation Products And Raw materials

Raw materials

t-butyl 6-bromo-2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridine-1-carboxylate 2-chloro-4-(1-methyl-1H-imidazol-5-yl)aniline 4-Amino-3-chlorophenylboronic acid, pinacol ester

Preparation Products

CCT251455 Suppliers

Global( 8)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 19892 58
Aladdin Scientific 		+1-+1(833)-552-7181 sales@aladdinsci.com United States 52927 58
Fan De(Beijing) Biotechnology Co., Ltd. 15911056312 liming@bio-fount.com China 9730 58
ShangHai ChuanQian Chemcial Technique Centre 15869524721 3525679403@qq.com China 3617 58
cjbscvictory 13348960310 13348960310 3003867561@qq.com China 10011 58
Shanghai tingchong biology science and technology co., ltd 18964309092 18964309092 2769493375@qq.com China 2635 58
TargetMol Chemicals Inc. 4008200310 marketing@tsbiochem.com China 24017 58
RD International Technology Co., Limited 18024082417 market@ubiochem.com China 9155 58
Supplier Advantage
TargetMol Chemicals Inc. 		58
Aladdin Scientific 		58
Fan De(Beijing) Biotechnology Co., Ltd. 58
ShangHai ChuanQian Chemcial Technique Centre 58
cjbscvictory 58
Shanghai tingchong biology science and technology co., ltd 58
TargetMol Chemicals Inc. 58
RD International Technology Co., Limited 58
CCT251455 BXKNUXDLZJPPBO-UHFFFAOYSA-N CCT251455,CCT-251455 1H-Pyrrolo[3,2-c]pyridine-1-carboxylic acid, 6-[[2-chloro-4-(1-methyl-1H-imidazol-5-yl)phenyl]amino]-2-(1-methyl-1H-pyrazol-4-yl)-, 1,1-dimethylethyl ester 1400284-80-1