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CCT251455

CCT251455 structure

CAS No.: 1400284-80-1

Chemical Name:: CCT251455

Synonyms: CCT251455;CCT251455,CCT-251455;BXKNUXDLZJPPBO-UHFFFAOYSA-N;1H-Pyrrolo[3,2-c]pyridine-1-carboxylic acid, 6-[[2-chloro-4-(1-methyl-1H-imidazol-5-yl)phenyl]amino]-2-(1-methyl-1H-pyrazol-4-yl)-, 1,1-dimethylethyl ester

CBNumber:: CB63339864

Molecular Formula:: C26H26ClN7O2

Molecular Weight:: 503.98

MDL Number:: MFCD28399124

MOL File:: 1400284-80-1.mol

Last updated:2024-10-28 16:48:35

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CCT251455 Properties

Boiling point	731.0±70.0 °C(Predicted)
Density	1.34±0.1 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	Soluble in DMSO
form	Solid
pka	7.86±0.30(Predicted)
color	Light yellow to brown

CCT251455 Chemical Properties,Uses,Production

Description

CCT251455 is a potent and selecltive MSP1 inhibitor with potential anticancer activitiy. The protein kinase MPS1 is a crucial component of the spindle assembly checkpoint signal and is aberrantly overexpressed in many human cancers. MPS1 is one of the top 25 genes overexpressed in tumors with chromosomal instability and aneuploidy. PTEN-deficient breast tumor cells are particularly dependent upon MPS1 for their survival, making it a target of significant interest in oncology. CCT251455 stabilizes an inactive conformation of MPS1 with the activation loop ordered in a manner incompatible with ATP and substrate-peptide binding; it displays a favorable oral pharmacokinetic profile, shows dose-dependent inhibition of MPS1 in an HCT116 human tumor xenograft model, and is an attractive tool compound to elucidate further the therapeutic potential of MPS1 inhibition.

CCT251455 synthesis

Synthesis of CCT251455 from 2-chloro-4-(1-methyl-1H-imidazol-5-yl)aniline and t-butyl 6-bromo-2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridine-1-carboxylate

CCT251455 Preparation Products And Raw materials

Raw materials

t-butyl 6-bromo-2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridine-1-carboxylate 2-chloro-4-(1-methyl-1H-imidazol-5-yl)aniline 4-Amino-3-chlorophenylboronic acid, pinacol ester

Preparation Products

CCT251455 Suppliers

Global( 10)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	32072	58
TargetMol Chemicals Inc.		support@targetmol.com	United States	38466	58
Aladdin Scientific	+1-+1(833)-552-7181	sales@aladdinsci.com	United States	52925	58
TargetMol Chemicals Inc.	+8613564774135	zijue.cai@tsbiochem.com	United States	19863	58
Fan De(Beijing) Biotechnology Co., Ltd.	15911056312	liming@bio-fount.com	China	9729	58
ShangHai ChuanQian Chemcial Technique Centre	15869524721	3525679403@qq.com	China	3983	58
cjbscvictory	13348960310 13348960310	3003867561@qq.com	China	10001	58
Shanghai tingchong biology science and technology co., ltd	18964309092 18964309092	2769493375@qq.com	China	2634	58
TargetMol Chemicals Inc.	4008200310	marketing@tsbiochem.com	China	24648	58
RD International Technology Co., Limited	18024082417	market@ubiochem.com	China	9272	58

Supplier	Advantage
TargetMol Chemicals Inc.	58
TargetMol Chemicals Inc.	58
Aladdin Scientific	58
TargetMol Chemicals Inc.	58
Fan De(Beijing) Biotechnology Co., Ltd.	58
ShangHai ChuanQian Chemcial Technique Centre	58
cjbscvictory	58
Shanghai tingchong biology science and technology co., ltd	58
TargetMol Chemicals Inc.	58
RD International Technology Co., Limited	58

View Lastest Price from CCT251455 manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2024-10-28	CCT251455 1400284-80-1	US $2380.00-1820.00 / mg			10g	TargetMol Chemicals Inc.

CCT251455
1400284-80-1
US $2380.00-1820.00 / mg
TargetMol Chemicals Inc.

CCT251455 BXKNUXDLZJPPBO-UHFFFAOYSA-N CCT251455,CCT-251455 1H-Pyrrolo[3,2-c]pyridine-1-carboxylic acid, 6-[[2-chloro-4-(1-methyl-1H-imidazol-5-yl)phenyl]amino]-2-(1-methyl-1H-pyrazol-4-yl)-, 1,1-dimethylethyl ester 1400284-80-1