ChemicalBook >> CAS DataBase List >>A-485
A-485
- CAS No.
- 1889279-16-6
- Chemical Name:
- A-485
- Synonyms
- A-486;A-485;A485;A 485;inhibit,HATs,A 485,Inhibitor,Epigenetic Reader Domain,Histone Acetyltransferase,HAT,A-485,A485;N-(4-Fluorobenzyl)-2-[(R)-5-(3-methylureido)-2’,4’-dioxo-2,3-dihydrospiro[indene-1,5’-oxazolidin]-3’-yl]-N-[(S)-1,1,1-trifluoro-2-propyl]acetamide;N-(4-Fluorobenzyl)-2-((R)-5-(3-methylureido)-2',4'-dioxo-2,3-dihydrospiro[indene-1,5'-oxazolidin]-3'-yl)-N-((S)-1,1,1-trifluoropropan-2-yl)acetamide;N-(4-Fluorobenzyl)-2-((R)-5-(3-methylureido)-2',4'-dioxo-2,3-dihydrospiro[indene-1,5'-oxazolidin]-3'-yl)-N-((S)-1,1,1-trifluoropropan-2-yl)acetamide;(1R)-N-[(4-Fluorophenyl)methyl]-2,3-dihydro-5-[[(methylamino)carbonyl]amino]-2',4'-dioxo-N-[(1S)-2,2,2-trifluoro-1-methylethyl]spiro[1H-indene-1,5'-oxazolidine]-3'-acetamide;Spiro[1H-indene-1,5'-oxazolidine]-3'-acetamide, N-[(4-fluorophenyl)methyl]-2,3-dihydro-5-[[(methylamino)carbonyl]amino]-2',4'-dioxo-N-[(1S)-2,2,2-trifluoro-1-methylethyl]-, (1R)-
- CBNumber:
- CB63386444
- Molecular Formula:
- C25H24F4N4O5
- Molecular Weight:
- 536.48
- MDL Number:
- MFCD31619258
- MOL File:
- 1889279-16-6.mol
Last updated:2024-11-13 21:11:14
| Density | 1.46±0.1 g/cm3(Predicted) |
|---|---|
| storage temp. | 2-8°C |
| solubility |
DMSO:97.41(Max Conc. mg/mL);181.57(Max Conc. mM) DMF:10.0(Max Conc. mg/mL);18.64(Max Conc. mM) Ethanol:57.88(Max Conc. mg/mL);107.89(Max Conc. mM) Ethanol:PBS (pH 7.2) (1:3):0.25(Max Conc. mg/mL);0.47(Max Conc. mM) |
| form | A crystalline solid |
| pka | 14.07±0.46(Predicted) |
| color | White to off-white |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
A-485 price More Price(29)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 24119 | A-485 | 1889279-16-6 | 1mg | $49 | 2024-03-01 | Buy |
| Cayman Chemical | 24119 | A-485 | 1889279-16-6 | 25mg | $711 | 2024-03-01 | Buy |
| Cayman Chemical | 24119 | A-485 | 1889279-16-6 | 5mg | $190 | 2024-03-01 | Buy |
| Cayman Chemical | 24119 | A-485 | 1889279-16-6 | 10mg | $333 | 2024-03-01 | Buy |
| Tocris | 6387 | A485 ≥98%(HPLC) | 1889279-16-6 | 5 | $257 | 2021-12-16 | Buy |
A-485 Chemical Properties,Uses,Production
Uses
A-485 is potent and selective p300/CREB-binding protein (CBP) HAT domain inhibitor (IC50 values are 2.6 and 9.8 nM for the CBP-bromodomain HAT-C/H3 (BHC) and p300-BHC domains, respectively). Displays > 1000-fold selectivity over closely related HATs. Suppresses proliferation in several hematological malignancies and AR+ prostate cancer cell lines in vitro. Inhibits tumor growth in a castration-resistant prostate cancer xenograft model. Orally bioavailable.
storage
Store at -20°C
A-485 Preparation Products And Raw materials
Raw materials
Preparation Products
A-485 Suppliers
Global( 82)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Zhejiang ZETian Fine Chemicals Co. LTD | +8618957127338 | stella@zetchem.com | China | 2136 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32165 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6312 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10473 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| LEAP CHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 24727 | 58 |
| Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 | sales@chemhifuture.com | China | 3135 | 58 |
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38632 | 58 | |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8467 | 58 |
| Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd | +86-18341751992 +86-15382112998 | 757984502@qq.com | China | 892 | 58 |
(1R)-N-[(4-Fluorophenyl)methyl]-2,3-dihydro-5-[[(methylamino)carbonyl]amino]-2',4'-dioxo-N-[(1S)-2,2,2-trifluoro-1-methylethyl]spiro[1H-indene-1,5'-oxazolidine]-3'-acetamide
A-485
A485;A 485
Spiro[1H-indene-1,5'-oxazolidine]-3'-acetamide, N-[(4-fluorophenyl)methyl]-2,3-dihydro-5-[[(methylamino)carbonyl]amino]-2',4'-dioxo-N-[(1S)-2,2,2-trifluoro-1-methylethyl]-, (1R)-
A-486
N-(4-Fluorobenzyl)-2-((R)-5-(3-methylureido)-2',4'-dioxo-2,3-dihydrospiro[indene-1,5'-oxazolidin]-3'-yl)-N-((S)-1,1,1-trifluoropropan-2-yl)acetamide
inhibit,HATs,A 485,Inhibitor,Epigenetic Reader Domain,Histone Acetyltransferase,HAT,A-485,A485
N-(4-Fluorobenzyl)-2-((R)-5-(3-methylureido)-2',4'-dioxo-2,3-dihydrospiro[indene-1,5'-oxazolidin]-3'-yl)-N-((S)-1,1,1-trifluoropropan-2-yl)acetamide
N-(4-Fluorobenzyl)-2-[(R)-5-(3-methylureido)-2’,4’-dioxo-2,3-dihydrospiro[indene-1,5’-oxazolidin]-3’-yl]-N-[(S)-1,1,1-trifluoro-2-propyl]acetamide
1889279-16-6
C25H24F4N4O5
intermediate