|
|
| Product Name: | A-485 | | Synonyms: | (1R)-N-[(4-Fluorophenyl)methyl]-2,3-dihydro-5-[[(methylamino)carbonyl]amino]-2',4'-dioxo-N-[(1S)-2,2,2-trifluoro-1-methylethyl]spiro[1H-indene-1,5'-oxazolidine]-3'-acetamide;A-485;A485;A 485;Spiro[1H-indene-1,5'-oxazolidine]-3'-acetamide, N-[(4-fluorophenyl)methyl]-2,3-dihydro-5-[[(methylamino)carbonyl]amino]-2',4'-dioxo-N-[(1S)-2,2,2-trifluoro-1-methylethyl]-, (1R)-;A-486;N-(4-Fluorobenzyl)-2-((R)-5-(3-methylureido)-2',4'-dioxo-2,3-dihydrospiro[indene-1,5'-oxazolidin]-3'-yl)-N-((S)-1,1,1-trifluoropropan-2-yl)acetamide;inhibit,HATs,A 485,Inhibitor,Epigenetic Reader Domain,Histone Acetyltransferase,HAT,A-485,A485;N-(4-Fluorobenzyl)-2-((R)-5-(3-methylureido)-2',4'-dioxo-2,3-dihydrospiro[indene-1,5'-oxazolidin]-3'-yl)-N-((S)-1,1,1-trifluoropropan-2-yl)acetamide | | CAS: | 1889279-16-6 | | MF: | C25H24F4N4O5 | | MW: | 536.48 | | EINECS: | | | Product Categories: | intermediate | | Mol File: | 1889279-16-6.mol |  |
| | A-485 Chemical Properties |
| density | 1.46±0.1 g/cm3(Predicted) | | storage temp. | 2-8°C | | solubility | DMSO:97.41(Max Conc. mg/mL);181.57(Max Conc. mM)
DMF:10.0(Max Conc. mg/mL);18.64(Max Conc. mM)
Ethanol:57.88(Max Conc. mg/mL);107.89(Max Conc. mM)
Ethanol:PBS (pH 7.2) (1:3):0.25(Max Conc. mg/mL);0.47(Max Conc. mM) | | form | A crystalline solid | | pka | 14.07±0.46(Predicted) | | color | White to off-white |
| | A-485 Usage And Synthesis |
| Uses | A-485 is potent and selective p300/CREB-binding protein (CBP) HAT domain inhibitor (IC50 values are 2.6 and 9.8 nM for the CBP-bromodomain HAT-C/H3 (BHC) and p300-BHC domains, respectively). Displays > 1000-fold selectivity over closely related HATs. Suppresses proliferation in several hematological malignancies and AR+ prostate cancer cell lines in vitro. Inhibits tumor growth in a castration-resistant prostate cancer xenograft model. Orally bioavailable. | | storage | Store at -20°C |
| | A-485 Preparation Products And Raw materials |
|