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BENZETIMIDE

BENZETIMIDE structure

CAS No.: 21888-98-2

Chemical Name:: BENZETIMIDE

Synonyms: R 16470;BENZETIMIDE;Dexbenzetimide;DEXETIMIDE HCL;(+)-Benzetimide;RSYYBENZETIMIDE;Dextrobenzetimide;(S)-(+)-Dexetimide;BENZETIMIDE USP/EP/BP;(+)-DEXETIMIDE HYDROCHLORIDE

CBNumber:: CB6343451

Molecular Formula:: C23H26N2O2

Molecular Weight:: 362.46

MDL Number:: MFCD00242706

MOL File:: 21888-98-2.mol

Last updated:2024-10-23 13:36:13

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BENZETIMIDE Properties

Melting point	181-183°
alpha	D20 +125° (chloroform)
Boiling point	543.9±50.0 °C(Predicted)
Density	1.178±0.06 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	DMSO: ≥ 100 mg/mL (275.89 mM)
pka	11.20±0.40(Predicted)
form	Solid
color	White to off-white
FDA UNII	43477QYX3D

SAFETY

Risk and Safety Statements

RIDADR	3249
HazardClass	6.1(b)
PackingGroup	III

BENZETIMIDE price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
ChemScene	CS-0026226	Dexetimide 99.20%	21888-98-2	10mg	$90	2021-12-16	Buy
ChemScene	CS-0026226	Dexetimide 99.20%	21888-98-2	50mg	$210	2021-12-16	Buy
American Custom Chemicals Corporation	API0006654	DEXETIMIDE 95.00%	21888-98-2	5MG	$504.38	2021-12-16	Buy

Product number	Packaging	Price	Buy
CS-0026226	10mg	$90	Buy
CS-0026226	50mg	$210	Buy
API0006654	5MG	$504.38	Buy

BENZETIMIDE Chemical Properties,Uses,Production

Originator

Tremblex,Brocades,Italy,1981

Uses

Anticholinergic.

Definition

ChEBI: Dexetimide is a member of piperidines.

Manufacturing Process

400 parts glacial acetic acid are cooled to 10°C to 20°C. Then there are added first dropwise 300 parts concentrated sulfuric acid followed by portionwise addition of 50 parts dl-1-benzyl-4-(1,3-dicyano-1-phenylpropyl)-piperidine hydrochloride at the same temperature. After the addition is complete, the whole is heated to 125°C in the course of 15 to 20 minutes. This temperature is then maintained for 10 minutes. After cooling, the reaction mixture is poured into ice, alkalized with NH4OH at a temperature < 20°C and extracted with chloroform. The chloroform layer is first washed twice with a K2CO3 5% solution, and then washed twice with water, dried over MgSO4, filtered and evaporated. The residue is dissolved in a mixture of 320 parts acetone and 600 parts diisopropylether, filtered and HCl gas is introduced into the filtrate. The solid hydrochloride is filtered off and dried, to yield 43 parts less pure lbenzyl-4-(2.6-dioxo-3-phenyl-3-piperidyl)-piperidine hydrochloride, melting point 283°C to 294°C.
A sample of 4 parts is recrystallized from a boiling mixture of 80 parts isopropanol, 40 parts methanol and 500 parts water. The whole is filtered and after cooling the filtrate overnight at -20°C, 1-benzyl-4-(2,6-dioxo-3phenyl-3- piperidyl)-piperidine hydrochloride is obtained, melting point 299°C to 301.5°C, as a white amorphous powder.
The dextro-isomer may be separated via the dextro-camphorsulfonate of the base.

Therapeutic Function

Anticholinergic (ophthalmic)

BENZETIMIDE synthesis

Synthesis of BENZETIMIDE from 3-(1-benzyl-4-piperidyl)-3-phenyl-piperidine-2,6-dione

BENZETIMIDE Preparation Products And Raw materials

Raw materials

Hydrochloric acid

Preparation Products

BENZETIMIDE Suppliers

Global( 36)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	32165	58
Career Henan Chemica Co	+86-0371-86658258 +8613203830695	laboratory@coreychem.com	China	30240	58
Shaanxi Didu New Materials Co. Ltd	+86-89586680 +86-13289823923	1026@dideu.com	China	8670	58
TargetMol Chemicals Inc.		support@targetmol.com	United States	38632	58
GIHI CHEMICALS CO.,LIMITED	+8618058761490	info@gihichemicals.com	China	49979	58
Shanghai Acmec Biochemical Technology Co., Ltd.	+undefined18621343501	product@acmec-e.com	China	33338	58
SHANGHAI KEAN TECHNOLOGY CO., LTD.	+8613817748580	cooperation@kean-chem.com	China	40066	58
LGM Pharma	1-(800)-881-8210	inquiries@lgmpharma.com	United States	2123	70
Credit Asia Chemical Co., Ltd.	+86 (21) 61124340		China	9756	58
Beijing Solarbio Science & Tecnology Co., Ltd.	010-50973130 4009686088	3193328036@qq.com	China	29785	68

Supplier	Advantage
TargetMol Chemicals Inc.	58
Career Henan Chemica Co	58
Shaanxi Didu New Materials Co. Ltd	58
TargetMol Chemicals Inc.	58
GIHI CHEMICALS CO.,LIMITED	58
Shanghai Acmec Biochemical Technology Co., Ltd.	58
SHANGHAI KEAN TECHNOLOGY CO., LTD.	58
LGM Pharma	70
Credit Asia Chemical Co., Ltd.	58
Beijing Solarbio Science & Tecnology Co., Ltd.	68

View Lastest Price from BENZETIMIDE manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2024-10-24	Dexetimide 21888-98-2	US $57.00-37.00 / mg			10g	TargetMol Chemicals Inc.

Dexetimide
21888-98-2
US $57.00-37.00 / mg
TargetMol Chemicals Inc.

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1of4

[3,4'-Bipiperidine]-2,6-dione, 3-phenyl-1'-(phenylmethyl)-, (S)- Dexbenzetimide Dextrobenzetimide DEXETIMIDE HCL (+)-DEXETIMIDE HYDROCHLORIDE BENZETIMIDE 3-PHENYL-1'-(PHENYLMETHYL)-[3,4'-BIPIPERIDINE]-2,6-DIONE HYDROCHLORIDE R 16470 (S)-(+)-3-PHENYL-1'-(PHENYLMETHYL)-[3,4'-BIPIPERIDINE]-2,6-DIONE, HCL S(+)-DEXETIMIDE HYDROCHLORIDE S(+)-DEXETIMIDE HYDROCHLORIDE (R16470) H IGH AFFINITY MUSCARI (3S)-3-(1-Benzyl-4-piperidyl)-3-phenylpiperidine-2,6-dione (S)-(+)-Dexetimide [3,4'-Bipiperidine]-2,6-dione, 3-phenyl-1'-(phenylmethyl)-, (3S)- BENZETIMIDE USP/EP/BP (+)-Benzetimide RSYYBENZETIMIDE 21888-98-2 21888-96-9