ChemicalBook >> CAS DataBase List >>(-)-3,4-Dihydroxynorephedrine

(-)-3,4-Dihydroxynorephedrine

CAS No.
829-74-3
Chemical Name:
(-)-3,4-Dihydroxynorephedrine
Synonyms
BA 2818;Nordefri;CORBADRINE;l-Cobefrin;Neo-cobefrin;LEVONORDEFRIN;Isoadrenaline;D-(-)-Cobefrin;Levonordefrin Base;Dioxynorepinephrine
CBNumber:
CB6344074
Molecular Formula:
C9H13NO3
Molecular Weight:
183.2
MDL Number:
MFCD00134415
MOL File:
829-74-3.mol
Last updated:2023-06-08 09:02:54

(-)-3,4-Dihydroxynorephedrine Properties

Melting point 212-215°C dec.
alpha D25 -31.0° (c = 0.5 in 0.01N HCl)
Boiling point 431.6±40.0 °C(Predicted)
Density 1.328±0.06 g/cm3(Predicted)
storage temp. −20°C
solubility DMSO: soluble5mg/mL, clear (warmed)
pka 9.59±0.10(Predicted)
form powder
color white to light brown
Merck 13,6725
EWG's Food Scores 1
FDA UNII V008L6478D

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302+H312+H332-H315-H319-H335
Precautionary statements  P261-P280-P301+P312+P330-P305+P351+P338
Hazard Codes  Xn
Risk Statements  20/21/22-36/37/38
Safety Statements  26-36
RIDADR  UN 2811 6.1 / PGII
WGK Germany  3
HS Code  2922504500
Toxicity LD50 in mice (mg/kg): 12.6 i.v. (Luduena)
NFPA 704
0
3 0

(-)-3,4-Dihydroxynorephedrine Chemical Properties,Uses,Production

Chemical Properties

White Powder

Uses

A vasoconstrictor which also increases the potency and duration of anesthesia produced by local anesthetics

Uses

Vasoconstrictor;Adrenergic receptor agonist

Definition

ChEBI: Alpha-methylnoradrenaline is a catecholamine in which the 2-aminoethyl group is substituted with a hydroxy group at C-1 and a methyl group at C-2, with configurations 1R,2S. A metabolite of alpha-methyl-L-dopa, it is an alpha2-adrenergic agonist and acts as a topical nasal decongestant and vasoconstrictor, most often used in dentistry. It has a role as an alpha-adrenergic agonist, a vasoconstrictor agent and a nasal decongestant.

brand name

Neo-Cobefrin (Cook-Waite).

(-)-3,4-Dihydroxynorephedrine Preparation Products And Raw materials

Raw materials

Preparation Products

4-[2-AMINO-1-HYDROXYPROPYL]-1,2-BENZENEDIOL (-)3,4-DIHYDROXYNOREPHEDRINE (-)-3,4-DIHYDROXYNOREPHREDRINE CORBADRINE LEVONORDEFRIN Dihydroxyphenylpropanolamine Dioxynorepinephrine Isoadrenaline Nordefri Corbadrine, Levonordefrin, l-Norephedrine (-)-3,4-DIHYDROXYNOREPHEDRINE, TECH., 90 % (-)-3,4-DIHYDROXYNOREPHEDRINE*APPROX. 90 % Corbadrine, Levonordefrin, (-)-α-methylnorepinephrine α-(1-Aminoethyl)-3,4-dihydroxybenzyl alcohol, (-)-α-Methylnorepinephrine, 4-(2-Amino-1-hydroxypropyl)-1,2-benzenediol, L-4-(2-Amino-1-hydroxypropyl)-1,2-benzenediol, Levonordefrin (-)-4-[(1R,2S)-2-Amino-1-hydroxypropyl]-1,2-benzenediol (1R,2S)-2-Amino-1-(3,4-dihydroxyphenyl)-1-propanol (-)-3,4-Dihydroxynorephedrine 4-(2-Amino-1-hydroxypropyl)benzene-1,2-diol Levonordefrin (200 mg) BA 2818 D-(-)-Cobefrin l-Cobefrin L-α-Methylnoradrenaline Neo-cobefrin α-(1-Aminoethyl)-3,4-dihydroxybenzyl alcohol, (-)-α-Methylnorepinephrine, 4-(2-Amino-1-hydroxypropyl)-1,2-benzenediol, L-4-(2-Amino-1-hydroxypropyl)-1,2-benzenediol 1,2-Benzenediol, 4-(2-amino-1-hydroxypropyl)- 1,2-Benzenediol, 4-(2-amino-1-hydroxypropyl)- (9CI) Levonordefrin Base 3,4-Dihydrophenyl-1-amino-2-propanol-1 BENZYL ALCOHOL, alpha-(1-AMINOETHYL)-3,4-DIHYDROXY- 4-(2-amino-1-hydroxy-propyl)pyrocatechol 4-dihydroxy Norephedrine LEVONORDEFRIN;CORBADRINE;(–)-Α-METHYL NORADRENALINE;(–)-3;4-DIHYDROXY NOREPHEDRINE 1,2-Benzenediol, 4-[(1R,2S)-2-amino-1-hydroxypropyl]- Levonordefrin (1362500) (–)-3,4-dihydroxy Norephedrine (–)-α-methyl Noradrenaline 829-74-3 HO2C6H3CHOHCHCH3NH2 DID - DIN Analytical Chromatography Product Catalog Alphabetic Analytical Standards Amines Aromatics Intermediates & Fine Chemicals Pharmaceuticals