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Naftopidil dihydrochloride

Naftopidil dihydrochloride structure

CAS No.: 57149-07-2

Chemical Name:: Naftopidil dihydrochloride

Synonyms: kt-611;Flivas;Avishot;Naftopil;BM-15275;Naftopiil;NafTopIDi1;NAFTOPIDIL;Nafitopidil;Naftopidil>

CBNumber:: CB6356910

Molecular Formula:: C24H28N2O3

Molecular Weight:: 392.49

MDL Number:: MFCD00153845

MOL File:: 57149-07-2.mol

Last updated:2025-04-01 13:12:09

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Naftopidil dihydrochloride Properties

Melting point	127 °C
Boiling point	517.2°C (rough estimate)
Density	1.1592 (rough estimate)
refractive index	1.6300 (estimate)
storage temp.	Sealed in dry,Room Temperature
solubility	methanol: >10 mg/mL
form	solid
pka	14.01±0.20(Predicted)
color	white
Merck	14,6356
CAS DataBase Reference	57149-07-2(CAS DataBase Reference)
FDA UNII	R9PHW59SFN
UNSPSC Code	12352200
NACRES	NA.77

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS08
Signal word	Warning
Hazard statements	H361
Precautionary statements	P201-P202-P281-P308+P313-P405-P501
RIDADR	3077
WGK Germany	3
RTECS	TL9336500
HS Code	29335990
Toxicity	LD50 in mice, rats (g/kg): 1.3, 6.4 orally (Himmel)

Naftopidil dihydrochloride price More Price(34)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	N158	Naftopidil hydrochloride hydrate solid	57149-07-2	25mg	$240	2024-03-01	Buy
Sigma-Aldrich	N158	Naftopidil hydrochloride hydrate solid	57149-07-2	100mg	$774	2023-01-07	Buy
TCI Chemical	N0832	Naftopidil >98.0%(HPLC)(T)	57149-07-2	5g	$50	2024-03-01	Buy
TRC	N213501	Naftopidil	57149-07-2	25mg	$80	2021-12-16	Buy
Usbiological	285070	Naftopidil	57149-07-2	1g	$345	2021-12-16	Buy

Product number	Packaging	Price	Buy
N158	25mg	$240	Buy
N158	100mg	$774	Buy
N0832	5g	$50	Buy
N213501	25mg	$80	Buy
285070	1g	$345	Buy

Naftopidil dihydrochloride Chemical Properties,Uses,Production

Description

Naftopidil was launched in Japan for the treatment of dysuria associated with benign prostatic hypertrophy (BPH). It can be prepared by a two step route starting with α-naphthol. Naftopidil is a potent postsynaptic-selective alpha-l-antagonist with a slightly higher affinity for the human prostatic than for the aortic alpha-adrenoceptor. It also shows a 5-HT1A agonistic effect, as well as a weak calcium antagonistic activity, but no alpha-2 or beta-adrenoreceptor affinity. In experiments with rats or rabbits, Naftopidil was shown to be more potent and selective for the urodynamic effect than the hypotensive effect. Aromatic or aliphatic hydroxylation are the major routes of metabolism, producing metabolites with a profile similar to the parent compound.

Chemical Properties

Off-White Solid

Originator

Boehringer Mannheim (Germany)

Uses

A α-1-Adrenergic receptor antagonist, antihypertensive.

Uses

Naftopidil is an α-1-adrenergic receptor antagonist. Naftopidil is used as an antihypertensive.

Uses

antihypertensive, alpha-blocker, 5HT1a agonist

Definition

ChEBI: Naftopidil is a member of piperazines.

brand name

Avishot;Flivas

Biological Activity

An α 1 -adrenoceptor antagonist with only weak antagonism at post-junctional α 2 receptors; a potent, persistent antihypertensive and vasodilator.

Naftopidil dihydrochloride Preparation Products And Raw materials

Raw materials

Sodium hydroxide Epichlorohydrin Tetrabutylammonium bromide 1-Naphthol 1-(2-Methoxyphenyl)piperazine

Preparation Products

Naftopidil dihydrochloride Suppliers

Global( 370)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hebei Chuanghai Biotechnology Co,.LTD	+86-13131129325	sales1@chuanghaibio.com	China	5868	58
Henan Aochuang Chemical Co.,Ltd.	+86-0371-63689365 +8618638391208	sales@aochuangchem.com	China	9297	58
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29858	58
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28172	58
Xiamen AmoyChem Co., Ltd	+86-86-5926051114 +8615060885618	sales@amoychem.com	China	6383	58
HubeiwidelychemicaltechnologyCo.,Ltd	18627774460	faith@widelychemical.com	CHINA	742	58
Shanghai Yingrui Biopharma Co.,Ltd	21-33585366	export01@shyrchem.com	CHINA	1319	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49732	58
Chengdu Aslee Biopharmaceuticals, Inc.	28-85305008		CHINA	964	58
SIMAGCHEM CORP	+86-13806087780	sale@simagchem.com	China	17365	58

Supplier	Advantage
Hebei Chuanghai Biotechnology Co,.LTD	58
Henan Aochuang Chemical Co.,Ltd.	58
career henan chemical co	58
Hubei Jusheng Technology Co.,Ltd.	58
Xiamen AmoyChem Co., Ltd	58
HubeiwidelychemicaltechnologyCo.,Ltd	58
Shanghai Yingrui Biopharma Co.,Ltd	58
CONIER CHEM AND PHARMA LIMITED	58
Chengdu Aslee Biopharmaceuticals, Inc.	58
SIMAGCHEM CORP	58

View Lastest Price from Naftopidil dihydrochloride manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-04-25	Naftopidil dihydrochloride 57149-07-2	US $0.00-0.00 / g	100g	99.0%	50kg/month	WUHAN FORTUNA CHEMICAL CO., LTD
2025-04-04	Naftopidil dihydrochloride 57149-07-2	US $0.00-0.00 / kg	1kg	98%	1Ton	Henan Aochuang Chemical Co.,Ltd.
2024-11-16	Naftopidil 57149-07-2	US $40.00 / mg		99.97%	10g	TargetMol Chemicals Inc.

Naftopidil dihydrochloride
57149-07-2
US $0.00-0.00 / g
99.0%
WUHAN FORTUNA CHEMICAL CO., LTD

Naftopidil dihydrochloride
57149-07-2
US $0.00-0.00 / kg
98%
Henan Aochuang Chemical Co.,Ltd.

Naftopidil
57149-07-2
US $40.00 / mg
99.97%
TargetMol Chemicals Inc.

Naftopidil dihydrochloride Spectrum

Naftopidil dihydrochloride(57149-07-2)¹HNMR

57149-07-2(Naftopidil dihydrochloride)Related Search:

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1of4

(+-)-1-(4-(2-methoxyphenyl)piperazinyl)-3-(1-naphthyloxy)propan-2-ol 4-(2-methoxyphenyl)-alpha-((1-naphthalenyloxy)methyl)-1-pioerazineethano 4-(2-methoxyphenyl)-alpha-((1-naphthalenyloxy)methyl)-1-pioerazineethanol kt-611 NAFTOPIDIL DIHYDROCHLORIDE (KT-611) A1 A DRENOCEPTOR ANTAG NAFTOPIDIL NafTopIDi1 4-(2-Methoxyphenyl)-alpha-[(1-naphthalenyloxy)methyl]-1-piperazineethanol dihydrochloride Naftopidil dihydrochloride Avishot Flivas Naftopidil DihydrochlorideSee: N213501 rac-4-(2-Methoxyphenyl)-a-[(1-naphthalenyloxy)methyl]-1-piperazineethanol Dihydrochloride 4-(2-Methoxyphenyl)-a-[(1-naphthalenyloxy)methyl]-1-piperazineethanol, 4-(2-methoxyphenyl)-α-[(1-naphthalenyloxy)methyl]-1-piperazineethanol dihydrochloride 1-Piperazineethanol, 4-(2-methoxyphenyl)-a-[(1-naphthalenyloxy)methyl]- (9CI) 3-[4-(2-Methoxyphenyl)piperazinyl]-1-naphthyloxypropan-2-ol Naftopidil and intermediates 1-[4-(2-Methoxyphenyl)piperazin-1-yl]-3-naphthalen-1-yloxy-propan-2-ol (R)-1-(1-Naphtyloxy)-3-[4-(2-methoxyphenyl)piperazino]-2-propanol [R,(+)]-1-[4-(2-Methoxyphenyl)-1-piperazinyl]-3-(1-naphtyloxy)-2-propanol (S)-1-(1-Naphtyloxy)-3-[4-(2-methoxyphenyl)piperazino]-2-propanol [S,(-)]-1-[4-(2-Methoxyphenyl)-1-piperazinyl]-3-(1-naphtyloxy)-2-propanol 1-[4-(2-Methoxyphenyl)-1-piperazinyl]-3-(1-naphtyloxy)-2-propanol 4-(2-Methoxyphenyl)-α-[(naphthalen-1-yloxy)methyl]piperazine-1-ethanol 4-(2-Methoxyphenyl)-α-[(1-naphthalenyloxy)methyl]-1-piperazineethanol hydrochloride hydrate 4-(2-Methoxyphenyl)-α-[(1-naphthalenyloxy)methyl]-1-piperazineethanolhydrochloride rac-4-(2-Methoxyphenyl)-α-[(1-naphthalenyloxy)methyl]-1-piperazineethanol Dihydrochloride 4-(2-Methoxyphenyl)-α-[(1-naphthalenyloxy)methyl]-1-piperazineethanol, KT-611, 4-(2-Methoxyphenyl)-α-[(1-naphthalenyloxy)methyl]-1-piperazineethanol hydrate hydrochloride Naftopidil hydrate hydrochloride Naftopidil(Flivas) CAS No:57149-07-2 1-Piperazineethanol,4-(2-Methoxyphenyl)-a-[(1-naphthalenyloxy)Methyl]- Naftopiil Naftopil Naftopidil hydrochloride hydrate 1-[4-(2-methoxyphenyl)-1-piperazinyl]-3-(1-naphthalenyloxy)-2-propanol dihydrochloride Nafitopidil Naftopidil dihydrochloride/Naftopidil BM-15275 1-[4-(2-Methoxyphenyl)piperazin-1-yl]-3-(1-naphthyloxy)propan-2-ol Naftopidil, 98%, a selective α1-adrenergic receptor antagonist Naftopidil> Naftopidil Naftopidil Naftopidil,>98% 1-Piperazineethanol, 4-(2-methoxyphenyl)-α-[(1-naphthalenyloxy)methyl]- 4-(2-Methoxyphenyl)-alpha-[(1-naphthalenyloxy)methyl]-1-piperazineethanol Naftopidil hydrochlo Naftopidil D7Q: What is Naftopidil D7 Q: What is the CAS Number of Naftopidil D7 Q: What is the storage condition of Naftopidil D7 Q: What are the applications of Naftopidil D7 NaftopidilQ: What is Naftopidil Q: What is the CAS Number of Naftopidil Q: What is the storage condition of Naftopidil Q: What are the applications of Naftopidil Naftopidil, ≥ 98.0% Naftopidil hydrochloride, alpha1 Adrenoceptor antagonist Naftopidil, 10 mM in DMSO Naftopidil - Bio-X ? 57149-07-2 7149-07-2 87233-19-2 C24H28N2O3