Naftopidil dihydrochloride
- CAS No.
- 57149-07-2
- Chemical Name:
- Naftopidil dihydrochloride
- Synonyms
- kt-611;Flivas;Avishot;Naftopil;BM-15275;Naftopiil;NafTopIDi1;NAFTOPIDIL;Nafitopidil;Naftopidil>
- CBNumber:
- CB6356910
- Molecular Formula:
- C24H28N2O3
- Molecular Weight:
- 392.49
- MDL Number:
- MFCD00153845
- MOL File:
- 57149-07-2.mol
Melting point | 127 °C |
---|---|
Boiling point | 517.2°C (rough estimate) |
Density | 1.1592 (rough estimate) |
refractive index | 1.6300 (estimate) |
storage temp. | Sealed in dry,Room Temperature |
solubility | methanol: >10 mg/mL |
form | solid |
pka | 14.01±0.20(Predicted) |
color | white |
Merck | 14,6356 |
CAS DataBase Reference | 57149-07-2(CAS DataBase Reference) |
FDA UNII | R9PHW59SFN |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS08 |
---|---|
Signal word | Warning |
Hazard statements | H361 |
Precautionary statements | P201-P202-P281-P308+P313-P405-P501 |
RIDADR | 3077 |
WGK Germany | 3 |
RTECS | TL9336500 |
HS Code | 29335990 |
Toxicity | LD50 in mice, rats (g/kg): 1.3, 6.4 orally (Himmel) |
Naftopidil dihydrochloride price More Price(34)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | N158 | Naftopidil hydrochloride hydrate solid | 57149-07-2 | 25mg | $240 | 2024-03-01 | Buy |
Sigma-Aldrich | N158 | Naftopidil hydrochloride hydrate solid | 57149-07-2 | 100mg | $774 | 2023-01-07 | Buy |
TCI Chemical | N0832 | Naftopidil >98.0%(HPLC)(T) | 57149-07-2 | 5g | $50 | 2024-03-01 | Buy |
TRC | N213501 | Naftopidil | 57149-07-2 | 25mg | $80 | 2021-12-16 | Buy |
Usbiological | 285070 | Naftopidil | 57149-07-2 | 1g | $345 | 2021-12-16 | Buy |
Naftopidil dihydrochloride Chemical Properties,Uses,Production
Description
Naftopidil was launched in Japan for the treatment of dysuria associated with benign prostatic hypertrophy (BPH). It can be prepared by a two step route starting with α-naphthol. Naftopidil is a potent postsynaptic-selective alpha-l-antagonist with a slightly higher affinity for the human prostatic than for the aortic alpha-adrenoceptor. It also shows a 5-HT1A agonistic effect, as well as a weak calcium antagonistic activity, but no alpha-2 or beta-adrenoreceptor affinity. In experiments with rats or rabbits, Naftopidil was shown to be more potent and selective for the urodynamic effect than the hypotensive effect. Aromatic or aliphatic hydroxylation are the major routes of metabolism, producing metabolites with a profile similar to the parent compound.
Chemical Properties
Off-White Solid
Originator
Boehringer Mannheim (Germany)
Uses
A α-1-Adrenergic receptor antagonist, antihypertensive.
Uses
Naftopidil is an α-1-adrenergic receptor antagonist. Naftopidil is used as an antihypertensive.
Uses
antihypertensive, alpha-blocker, 5HT1a agonist
Definition
ChEBI: Naftopidil is a member of piperazines.
brand name
Avishot;Flivas
Biological Activity
An α 1 -adrenoceptor antagonist with only weak antagonism at post-junctional α 2 receptors; a potent, persistent antihypertensive and vasodilator.
Naftopidil dihydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Hebei Guanlang Biotechnology Co,.LTD | +86-19930503253; +8619930503252 | daisy@crovellbio.com | China | 5835 | 58 |
career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29897 | 58 |
Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
Xiamen AmoyChem Co., Ltd | +86-592-6051114 +8618959220845 | sales@amoychem.com | China | 6387 | 58 |
HubeiwidelychemicaltechnologyCo.,Ltd | 18627774460 | faith@widelychemical.com | CHINA | 742 | 58 |
Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | sales@chemdad.com | China | 39916 | 58 |
Shanghai Yingrui Biopharma Co.,Ltd | 21-33585366 | export01@shyrchem.com | CHINA | 1320 | 58 |
CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49391 | 58 |
Fuxin Pharmaceutical | +86-021-021-50872116 +8613122107989 | contact@fuxinpharm.com | China | 10297 | 58 |
Neostar United (Changzhou) Industrial Co., Ltd. | +86-519-519-85557386 | marketing1@neostarunited.com | China | 11820 | 58 |
View Lastest Price from Naftopidil dihydrochloride manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2024-07-26 | Naftopidil
57149-07-2
|
US $19.10 / KG | 1KG | 99% | 10 ton | Hebei Guanlang Biotechnology Co,.LTD | ||
2024-07-25 | Naftopidil dihydrochloride
57149-07-2
|
US $0.00-0.00 / g | 100g | 99.0% | 50kg/month | WUHAN FORTUNA CHEMICAL CO., LTD | ||
2023-06-26 | Naftopidil
57149-07-2
|
US $120.00 / ASSAYS | 10g | >99% | 500kg/month | Hebei Mingeng Biotechnology Co., Ltd |
- Naftopidil
57149-07-2
- US $19.10 / KG
- 99%
- Hebei Guanlang Biotechnology Co,.LTD
- Naftopidil dihydrochloride
57149-07-2
- US $0.00-0.00 / g
- 99.0%
- WUHAN FORTUNA CHEMICAL CO., LTD
- Naftopidil
57149-07-2
- US $120.00 / ASSAYS
- >99%
- Hebei Mingeng Biotechnology Co., Ltd
57149-07-2(Naftopidil dihydrochloride)Related Search:
1of4