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Cefotiam hydrochloride

Cefotiam hydrochloride Structure
Cefotiam hydrochloride structure
CAS No.
66309-69-1
Chemical Name:
Cefotiam hydrochloride
Synonyms
CEFOTIAM 2HCL;Spizef;Ceftiam;Halospor;Sporidyn;Pansporin;Cefapicol;Pansporine;Kemisporin;Sepidnarin
CBNumber:
CB6386641
Molecular Formula:
C18H23N9O4S3.HCl
Molecular Weight:
562.08
MDL Number:
MFCD01682052
MOL File:
66309-69-1.mol
Last updated:2024-11-19 23:02:33
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Cefotiam hydrochloride Properties

Melting point >93°C (dec.)
Boiling point 94℃
RTECS XI0367000
Flash point >110°(230°F)
storage temp. Inert atmosphere,2-8°C
solubility H2O: ≥22M
form powder
color white to tan
Water Solubility Soluble in water
Stability Hygroscopic
InChIKey BWRRTAXZCKVRON-DGPOFWGLSA-N
CAS DataBase Reference 66309-69-1(CAS DataBase Reference)
FDA UNII H7V12WDZ93

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H319
Precautionary statements  P305+P351+P338
Hazard Codes  Xi
Risk Statements  36
Safety Statements  26
WGK Germany  3
HS Code  2941906000

Cefotiam hydrochloride price More Price(28)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich SML0056 Cefotiam dihydrochloride hydrate ≥98% (HPLC) 66309-69-1 10mg $34.4 2024-03-01 Buy
Alfa Aesar J66529 Cefotiam dihydrochloride 66309-69-1 100mg $403 2024-03-01 Buy
Alfa Aesar J66529 Cefotiam dihydrochloride 66309-69-1 50mg $262 2023-06-20 Buy
Sigma-Aldrich SML0056 Cefotiam dihydrochloride hydrate ≥98% (HPLC) 66309-69-1 50mg $268 2024-03-01 Buy
TRC C243005 Cefotiam dihydrochloride 66309-69-1 500mg $520 2021-12-16 Buy
Product number Packaging Price Buy
SML0056 10mg $34.4 Buy
J66529 100mg $403 Buy
J66529 50mg $262 Buy
SML0056 50mg $268 Buy
C243005 500mg $520 Buy

Cefotiam hydrochloride Chemical Properties,Uses,Production

Description

Cefotiam was synthesized by Takeda Chemicals Industries in 1977 as the first cephem derivative to introduce the aminothiazol group in the 7 side chain and the alkylated tetrazole group at the 3 side chain . This drug shows greater antibacterial activity against gram-negative bacteria than the earlier cephalosporins, including Enterobacter, Citrobacter, and indole-positive Proteus, and it retains the same activity as they have against gram-positive organisms. Its excellent activity against Klebsiella and Escherichia coli is based on its ability to penetrate the cell. This is 3- to 70-fold greater than that of cephalothin or cefazolin.

Uses

Cefotiam hydrochloride (SCE-963 hydrochloride) is a parenteral cephalosporin antibiotic. Cefotiam has broad-spectrum activity against Gram-positive and Gram-negative bacteria.

Definition

ChEBI: Cefotiam dihydrochloride is the dihydrochloride salt of cefotiam. It has a role as an antibacterial drug. It contains a cefotiam.

brand name

Ceradon (Takeda).

Pharmacokinetics

Cefotiam Hydrochloride is the hydrochloride salt form of cefotiam, a third-generation, semi-synthetic, beta-lactam cephalosporin antibiotic with antibacterial activity. Cefotiam binds to penicillin-binding proteins (PBPs), transpeptidases that are responsible for crosslinking of peptidoglycan. By preventing crosslinking of peptidoglycan, cell wall integrity is lost and cell wall synthesis is halted.

Cefotiam hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

Cefotiam hydrochloride Suppliers

Global( 291)Suppliers
Supplier Tel Email Country ProdList Advantage
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21632 55
Nanjing Finetech Chemical Co., Ltd. 		025-85710122 17714198479 sales@fine-chemtech.com CHINA 885 55
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29871 58
Shaanxi Yikanglong Biotechnology Co., Ltd. 		17791478691 yklbiotech@163.com CHINA 296 58
Hubei Jusheng Technology Co.,Ltd. 		18871490254 linda@hubeijusheng.com CHINA 28172 58
Chongqing Chemdad Co., Ltd 		+86-023-6139-8061 +86-86-13650506873 sales@chemdad.com China 39894 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 49732 58
SIMAGCHEM CORP 		+86-13806087780 sale@simagchem.com China 17365 58
Hebei Runbin Biotechnology Co. LTD 		13180553332 2179877681@qq.com CHINA 990 58
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32161 58
Supplier Advantage
Henan Tianfu Chemical Co.,Ltd. 		55
Nanjing Finetech Chemical Co., Ltd. 		55
career henan chemical co 		58
Shaanxi Yikanglong Biotechnology Co., Ltd. 		58
Hubei Jusheng Technology Co.,Ltd. 		58
Chongqing Chemdad Co., Ltd 		58
CONIER CHEM AND PHARMA LIMITED 		58
SIMAGCHEM CORP 		58
Hebei Runbin Biotechnology Co. LTD 		58
TargetMol Chemicals Inc. 		58

View Lastest Price from Cefotiam hydrochloride manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Cefotiam hydrochloride pictures 2025-02-12 Cefotiam hydrochloride
66309-69-1
 US $0.00-0.00 / Kg/Drum 1KG 81%min 500kg WUHAN FORTUNA CHEMICAL CO., LTD
Cefotiam hydrochloride pictures 2024-11-19 Cefotiam hydrochloride
66309-69-1
 US $39.00-80.00 / mg 98.74% 10g TargetMol Chemicals Inc.
cefotiam hydrochloride pictures 2020-12-11 cefotiam hydrochloride
66309-69-1
 US $220.00 / KG 10KG 99% 10 Hebei Henghe Import and Export Trading Co. LTD

Cefotiam hydrochloride Spectrum

Cefotiam hydrochloride(66309-69-1)1HNMR

66309-69-1(Cefotiam hydrochloride)Related Search:

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Cefetamet pivoxil hydrochloride Cefmenoxime hydrochloride Nitrocefin Ceftazidime 1-[2-(Dimethylamino)ethyl]-1H-tetrazole-5-thiol
2-Aminothiazole-4-acetic acid Metoclopramide monohydrochloride monohydrate Oxygen

1of4

cefotiam hydrochloride 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(2-amino-4-thiazolyl)acetyl]amino]-3-[[[1-[2-(dimethylamino)ethyl]-1H-tetrazol-5-yl]thio]methyl]-8-oxo-, dihydrochloride, (6R,7R)- 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(2-amino-4-thiazolyl)acetyl]amino]-3-[[[1-[2-(dimethylamino)ethyl]-1H-tetrazol-5-yl]thio]methyl]-8-oxo-, dihydrochloride, (6R-trans)- Abbott 48999 Halospor Pansporin Pansporine Spizef Sporidyn Cefotiam Hydrochloride (350 mg) (6R,7R)-7-[2-(2-aMino-1,3-thiazol-4-yl)acetaMido]-3-[({1-[2-(diMethylaMino)ethyl]-1H-1,2,3,4-tetrazol-5-yl}sulfanyl)Methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid (6r-trans)-7-[2-(2-aminothiazol-4-yl)acetamido]-3-[[[1-[2-(dimethylamino)ethyl]-1h-tetrazol-5-yl]thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid hydrochloride Cefapicol Kemisporin Sepidnarin (6R,7R)-7-[[2-(2-amino-1,3-thiazol-4-yl)acetyl]amino]-3-[[1-(2-dimethylaminoethyl)tetrazol-5-yl]sulfanylmethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid dihydrochloride (6R,7R)-7-[[2-(2-aminothiazol-4-yl)acetyl]amino]-3-[[[1-(2-dimethylaminoethyl)tetrazol-5-yl]thio]methyl]-8-keto-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid dihydrochloride (6R,7R)-7-[2-(2-azanyl-1,3-thiazol-4-yl)ethanoylamino]-3-[[1-(2-dimethylaminoethyl)-1,2,3,4-tetrazol-5-yl]sulfanylmethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid dihydrochloride Cefotiam Hydrochloride (325 mg) cefotiamdihydrochloride dihydrochloride,(6r-trans)--oxo (6R,7R)-7-[[2-(2-AMino-4-thiazolyl)acetyl]aMino]-3-[[[1-[2-(diMethylaMino)ethyl]-1H-tetrazol-5-yl]thio]Methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid Hydrochloride 20MG/100MG/KG 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid,7-[[2-(2-aMino-4-thiazolyl)acetyl]aMino]-3-[[[1-[2-(diMethylaMino)ethyl]-1H-tetrazol-5-yl]thio]Methyl]-8-oxo-,hydrochloride (1:2), (6R,7R)- (6R,7R)-7-[[2-(2-Amino-4-thiazolyl)acetyl]amino]-3-[[[1-[2-(dimethylamino)ethyl]-1H-tetrazol-5-yl]-thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid dihydrochloride hydrate Cefotiam dihydrochloride hydrate Ceftiam cefotian Hydrochloride Cefotiam DiHCl 7-[[2-(2-amino-4-thiazolyl)-1-oxoethyl]amino]-3-[[[1-[2-(dimethylamino)ethyl]-5-tetrazolyl]thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid hydrochloride Cefotiam Dihydrochloride(Crude) SCE-963 hydrochloride (6R,7R)-7-(2-(2-Aminothiazol-4-yl)acetamido)-3-(((1-(2-(dimethylamino)ethyl)-1H-tetrazol-5-yl)thio)methyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid dihydrochloride Cefotiam hydrochloride USP/EP/BP (6R-trans)-7-[2-(2-Aminothiazol-4-yl)acetamido]-3-[[[1-[2-(dimethylamino)ethyl]-1H-tetrazol-5-yl]thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-2-carbonsuredihydrochlorid Cefotiam hydrochloride Impurities Cefotiam Hydrochloride (1098005) CEFOTIAM 2HCL Cefotiame hydrochloride 66309-69-1 6309-69-1 66309-69-01 C18H23N9O4S3 C18H23N9O4S3HCl C18H23N9O4S32HCl C18H24ClN9O4S3 C18H25Cl2N9O4S3 59855 ANTRYPOL Intermediates & Fine Chemicals Pharmaceuticals