Ketorolac
- CAS No.
- 74103-06-3
- Chemical Name:
- Ketorolac
- Synonyms
- Ketorolac acid;Acular;Fluoxetin;(S)-Ketorolac;5-benzoyl-2,3-dihydro-1h-pyrrolizine-1-carboxylic acid;Dolac;rs37619;Lixidol;Tm-asyn;Toratex
- CBNumber:
- CB6392833
- Molecular Formula:
- C15H13NO3
- Molecular Weight:
- 255.27
- MDL Number:
- MFCD00864281
- MOL File:
- 74103-06-3.mol
Melting point | 160-161°C |
---|---|
Boiling point | 493.2±40.0 °C(Predicted) |
Density | 1.33±0.1 g/cm3(Predicted) |
storage temp. | 2-8°C |
solubility | Chloroform (Slightly), Methanol (Slightly) |
form | Solid |
pka | 3.49 ±0.02(at 25℃) |
color | Off-White |
Water Solubility | 183mg/L(32 ºC) |
CAS DataBase Reference | 74103-06-3(CAS DataBase Reference) |
NCI Dictionary of Cancer Terms | ketorolac |
FDA UNII | YZI5105V0L |
NCI Drug Dictionary | ketorolac |
ATC code | M01AB15,S01BC05 |
EPA Substance Registry System | 1H-Pyrrolizine-1-carboxylic acid, 5-benzoyl-2,3-dihydro- (74103-06-3) |
SAFETY
Risk and Safety Statements
Symbol(GHS) | ![]() GHS07 |
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Signal word | Warning | |||||||||
Hazard statements | H302-H315-H319-H332-H335 | |||||||||
Precautionary statements | P261-P280-P305+P351+P338 | |||||||||
RIDADR | 3249 | |||||||||
HazardClass | 6.1(a) | |||||||||
PackingGroup | II | |||||||||
HS Code | 2933998090 | |||||||||
Toxicity | LD50 orally in mice: ~200 mg/kg (Rooks) | |||||||||
NFPA 704 |
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Ketorolac price More Price(34)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Cayman Chemical | 9001148 | Ketorolac ≥95% | 74103-06-3 | 50mg | $15 | 2024-03-01 | Buy |
Cayman Chemical | 9001148 | Ketorolac ≥95% | 74103-06-3 | 100mg | $19 | 2024-03-01 | Buy |
Cayman Chemical | 9001148 | Ketorolac ≥95% | 74103-06-3 | 500mg | $79 | 2024-03-01 | Buy |
Cayman Chemical | 9001148 | Ketorolac ≥95% | 74103-06-3 | 1g | $110 | 2024-03-01 | Buy |
TRC | K235615 | racKetorolac | 74103-06-3 | 1g | $85 | 2021-12-16 | Buy |
Ketorolac Chemical Properties,Uses,Production
Chemical properties
It is crystallized in ethyl acetate - ether with a melting point of 160~161 degrees centigrade.The maximum absorption of UV (methanol):245,312m (epsilon 7080,17400). PKa3.49 + 0.02.Acute toxic LD50 mice (mg/kg): about 200 of oral administration. .(+) - configuration: crystallized from hexane ethyl acetate with the melting point of 174 degrees centigrade;The melting point is 154 156 degrees centigrade. [α]D+173° (C=1, methanol).(-) - configuration: crystallizzed from hexane ethyl acetate with melting point at 169~170 degrees centigrade; melting point is 153~155 degrees centigrade. [α]D-176° (C=1, methanol).
Pharmacological action
Ketorolac is also called ketorolac, acular and Ketorolac Tromethamine. It is a non steroid analgesic and anti-inflammatory drug, a derivative of pyrrolidone.The chemical structure and pharmacological action is similar to Tolectin, Zoaesthetic acid and Indometacin. By inhibiting cyclooxygenase, it inhibits the synthesis and release of prostaglandins, and produces anti-inflammatory effects. It can reduce the temperature induced by heat source, which is related to the inhibition of the synthesis of prostaglandin in the central nervous system.It has strong analgesic and moderate anti-inflammatory antipyretic and inhibition of platelet aggregation, and has no inhibition of respiration and addiction. In animal experiments, the analgesic effect is stronger than aspirin, indomethacin and naproxen.It is equal to or better than the anti-inflammatory effect of naproxen and indomethacin, phenylbutazone,Its antipyretic effect on rats are stronger than aspirin and phenylbutazone and the same with indomethacin and naproxen.It inhibits the platelet aggregation induced by arachidonic acid and collagen.But it does not inhibit the induction of adenosine diphosphate(ADP) ..This product is quickly and completely absorbed after the intramuscular injection, and is almost completely absorbed after oral administration.Food can slow down the absorption speed, but it does not affect the degree of absorption, and the bioavailability is 80% ~ 100%. 10 minutes after intramuscular injection of 30mg, it usually relieves the pain obviously. After 50 minutes, the peak of plasma concentration is up to 2.2 g/mL.After 30~60 minutes of oral administration, the pain is obviously relieved and the concentration of plasma is peak at 1.5 to 4 hours.The plasma half-life of young people is about 5.3 hours, and for the elderly it is about 7 hours, and the analgesic effect could be maintained for 6~8 hours. 91.4% will be excreted from the urinary tract, the rest will be excreted from the excrement.In patients with renal insufficiency, the total plasma clearance rate decreases and the half-life prolongs, so the dosage should be reduced.
Clinical application: ketorolac is mainly used for short-term pain treatment including postoperative pain (such as the abdomen, chest, Urology, gynecology, Department of Stomatology, orthopedic surgery and pain) as well as the acute skeletal muscle pain caused by various causes, such as sprain, dislocation, fracture and soft tissue injury, and other pain caused by other diseases, such as postpartum pain, acute renal colic, toothache, sciatica, late cancer pain, wound pain, biliary colic, etc.. It can be used as a substitute for morphine and pethidine.
Chemical Properties
Light yellow solid
Uses
antiarrhythmic
Uses
Ketorolac-d5 is a labeled analogue of Ketorolac, a Prostaglandin biosynthesis inhibitor. Analgesic; anti-inflammatory.
Uses
prostaglandin F2a analogue
Indications
Ketorolac (Toradol), an NSAID chemically related to indomethacin and tolmetin, is mainly used as an analgesic, not for the treatment of inflammatory disease. It is available in oral, parenteral, and topical formulations.
Definition
ChEBI: Ketorolac is a racemate comprising equimolar amounts of (R)-(+)- and (S)-(-)-5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid. While only the (S)-(-) enantiomer is a COX1 and COX2 inhibitor, the (R)-(+) enantiomer exhibits potent analgesic activity. A non-steroidal anti-inflammatory drug, ketorolac is mainly used (generally as the tromethamine salt) for its potent analgesic properties in the short-term management of post-operative pain, and in eye drops to relieve the ocular itching associated with seasonal allergic conjunctivitis. It was withdrawn from the market in many countries in 1993 following association with haemorrhage and renal failure. It has a role as a cyclooxygenase 2 inhibitor, a cyclooxygenase 1 inhibitor, a non-steroidal anti-inflammatory drug and an analgesic. It contains a (R)-ketorolac and a (S)-ketorolac. It is a conjugate acid of a ketorolac(1-).
brand name
Acular (Allergan); Toradol (Roche).
World Health Organization (WHO)
Ketorolac is a nonsteroidal anti-inflammatory agent used in the management of moderate to severe acute post-operative pain. It remains on the market in many countries with restrictions on its use.
Biological Functions
Ketorolac (Toradol) is an NSAID with very mild antiinflammatory and antipyretic activity. It is a potent analgesic for postoperative pain. Its efficacy is equivalent to that of low doses of morphine in the control of pain. For this reason it is often combined with opioids to reduce opioid dose and related side effects while providing adequate pain relief. It is also used to replace the opioids in some patients with opioid sensitivity. The mechanism of action of ketorolac involves the inhibition of COX and decreased formation of prostaglandins. However, some evidence exists that ketorolac may stimulate the release of endogenous opioids as a part of its analgesic activity.
General Description
Ketorolac tromethamine (Toradol), marketed as a mixture of(R)- and (S)-ketorolac enantiomers, is a potent NSAID analgesicindicated for the treatment of moderately severe, acutepain. It should be noted that the pharmacokinetic dispositionof ketorolac in humans is subject to marked enantioselectivity.Thus, it is important to monitor the individual blood levelsso an accurate assessment of its therapeutic action can bemade correctly. However, it should be noted that, beingone of the conventional NSAIDs with highest risk of GIcomplications, its administration should not exceed 5 days.
Clinical Use
Ketorolac is a nonsteroidal anti-inflammatory drug mainly used for the treatment of moderate to severe postoperative pain. Ketorolac shows a balanced inhibition of COX-1 and COX-2 in cultured human cells . Ketorolac is mostly used as the tromethamine salt. Due to a number of severe side effects including gastrointestinal disturbances, impairment of liver functions, renal failures, skin irritations, and other hypersensitivity reaction it has been withdrawn in many countries.
Synthesis
Benzoylation of 2-methylthiopyrrole
with N,N-dimethylbenzamide in the
presence of POCl3 in refluxing CH2Cl2 gives
5-benzoyl-2-methylthiopyrrole, which is condensed
with spiro-5,7-dioxa-6,6-dimethyloctane-
4,8-dione by means of NaH in DMF.
Oxidation of this product with m-chloroperbenzoic
acid in CH2Cl2 affords the sulfone, which
is submitted to methanolysis with methanol and
HCl giving 1-(3,3-dimethoxycarbonylpropyl)-
2-methanesulfonyl-5-benzoylpyrrole. Cyclization with NaH inDMFyields dimethyl-5-benzoyl-
1,2-dihydro-3H-pyrrolopyrrole-1,1-
dicarboxylate, which is finally hydrolyzed and
decarboxylated withKOHin refluxing methanol
.
Ketorolac Preparation Products And Raw materials
Raw materials
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Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Shaanxi Haibo Biotechnology Co., Ltd | +undefined18602966907 | qinhe02@xaltbio.com | China | 1000 | 58 |
Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20294 | 58 |
Hebei Mojin Biotechnology Co.,Ltd | +8613288715578 | angelia@hbmojin.com | China | 830 | 58 |
Hebei Ganmiao New material Technology Co., LTD | +86-17332992504 +86-17332992504 | sales8@hbganmiao.com | China | 300 | 58 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21668 | 55 |
Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 | product@chemlin.com.cn | CHINA | 3012 | 60 |
Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 19343 | 58 |
Changzhou Ditong Chemical Co.,Ltd | +86-0519-88299272 | info@edengenechem.com | China | 2169 | 58 |
Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22968 | 58 |
Shanghai Longyu Biotechnology Co., Ltd. | +8619521488211 | info@longyupharma.com | China | 2534 | 58 |
View Lastest Price from Ketorolac manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
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2024-08-22 | Ketorolac
74103-06-3
|
US $0.00-0.00 / Kg/Drum | 1KG | 98%min | 500KGS | WUHAN FORTUNA CHEMICAL CO., LTD | |
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2024-08-20 | Ketorolac
74103-06-3
|
US $9.00-5.00 / kg | 1kg | 99.9% | 200ton | Hebei Ganmiao New material Technology Co., LTD | |
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2024-08-14 | Ketorolac
74103-06-3
|
US $0.00 / kg | 1kg | 99% | 50000KG/month | Hebei Mojin Biotechnology Co.,Ltd |
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