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Felodipine

Felodipine Structure
Felodipine structure
CAS No.
86189-69-7
Chemical Name:
Felodipine
Synonyms
FLODIL;FELODAY;Agon sr;Perfuda;Perfudal;Felodipina;Felodipine;Brn 4331472;Felodipine Imp;Felodipine iMpurity
CBNumber:
CB6411200
Molecular Formula:
C18H19Cl2NO4
Molecular Weight:
384.25
MDL Number:
MFCD00868316
MOL File:
86189-69-7.mol
Last updated:2023-04-26 16:55:04
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Felodipine Properties

solubility DMSO: 28 mg/mL
form solid
color light yellow
BCS Class 2
CAS DataBase Reference 86189-69-7(CAS DataBase Reference)

Pharmacokinetic data

Protein binding 99%
Excreted unchanged in urine <0.5%
Volume of distribution 10
Biological half-life 24 / Unchanged

SAFETY

Risk and Safety Statements

Hazard Codes  Xn
Risk Statements  22
WGK Germany  3
RTECS  US7968700

Felodipine Chemical Properties,Uses,Production

Uses

Vasodilator.

brand name

Plendil (AstraZeneca).

Clinical Use

Calcium-channel blocker:
Hypertension
Angina

Drug interactions

Potentially hazardous interactions with other drugs
Aminophylline and theophylline: possibly increased aminophylline and theophylline concentration.
Anaesthetics: enhanced hypotensive effect.
Antibacterials metabolism possibly inhibited by clarithromycin, erythromycin and telithromycin.
Antidepressants: enhanced hypotensive effect with MAOIs.
Antiepileptics: effect reduced by carbamazepine, barbiturates, phenytoin and primidone.
Antifungals: metabolism inhibited by itraconazole and ketoconazole; negative inotropic effect possibly increased with itraconazole.
Antihypertensives: enhanced hypotensive effect, increased risk of first dose hypotensive effect of postsynaptic alpha-blockers.
Antivirals: concentration possibly increased by ritonavir; use with caution with telaprevir.
Grapefruit juice: concentration increased - avoid concomitant use.
Tacrolimus: possibly increased tacrolimus concentration

Metabolism

Felodipine is metabolised in the liver and all identified metabolites are devoid of vasodilating properties. Approximately 70% of a given dose is excreted as metabolites in the urine and about 10% with the faeces. Less than 0.5% of the dose is excreted unchanged in the urin

Felodipine Preparation Products And Raw materials

Raw materials

Preparation Products

Felodipine Suppliers

Global( 201)Suppliers
Supplier Tel Email Country ProdList Advantage
ENBRIDGE PHARMTECH CO., LTD.
+8613812269233 tinayang@enbridgepharm.com China 322 58
Shanghai Zheyan Biotech Co., Ltd. 		18017610038 zheyansh@163.com CHINA 3619 58
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29884 58
Shandong chuangyingchemical Co., Ltd. 		18853181302 sale@chuangyingchem.com CHINA 5906 58
Chongqing Chemdad Co., Ltd 		+86-023-6139-8061 +86-86-13650506873 sales@chemdad.com China 39894 58
Hebei shuoxi biotechnology co. LTD 		+8613081092107 CHINA 964 58
TopScience Biochemical 		00852-68527855 info@itopbiochem.com China Hong Kong 902 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 49374 58
SHANGHAI T&W PHARMACEUTICAL CO., LTD. 		+86-021-61551413 +8618813727289 contact@trustwe.com China 5738 58
ANHUI WITOP BIOTECH CO., LTD 		+8615255079626 eric@witopchemical.com China 23541 58
Supplier Advantage
ENBRIDGE PHARMTECH CO., LTD.
58
Shanghai Zheyan Biotech Co., Ltd. 		58
career henan chemical co 		58
Shandong chuangyingchemical Co., Ltd. 		58
Chongqing Chemdad Co., Ltd 		58
Hebei shuoxi biotechnology co. LTD 		58
TopScience Biochemical 		58
CONIER CHEM AND PHARMA LIMITED 		58
SHANGHAI T&W PHARMACEUTICAL CO., LTD. 		58
ANHUI WITOP BIOTECH CO., LTD 		58

View Lastest Price from Felodipine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Felodipine pictures 2024-11-15 Felodipine
86189-69-7
 US $0.00 / MG 10MG ≥98% HPLC 100KG Changsha Staherb Natural Ingredients Co., Ltd.
FELODIPINE pictures 2021-07-09 FELODIPINE
86189-69-7
 US $15.00-10.00 / KG 1KG 99%+ HPLC Monthly supply of 1 ton Zhuozhou Wenxi import and Export Co., Ltd
5-O-ethyl 3-O-methyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate pictures 2021-03-17 5-O-ethyl 3-O-methyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate
86189-69-7
 US $60.00 / KG 10g 99.8% 10tons Hebei shuoxi biotechnology co. LTD
  • Felodipine pictures
  • Felodipine
    86189-69-7
  • US $0.00 / MG
  • ≥98% HPLC
  • Changsha Staherb Natural Ingredients Co., Ltd.
  • FELODIPINE pictures
  • FELODIPINE
    86189-69-7
  • US $15.00-10.00 / KG
  • 99%+ HPLC
  • Zhuozhou Wenxi import and Export Co., Ltd

86189-69-7(Felodipine)Related Search:

Poly(dimethylsiloxane) Dimethyl fumarate Dimethyl sulfoxide Dimethyl sulfate Dichlorodimethylsilane
Dimethyl ether Dimethyl carbonate N,N-Dimethylacetamide ETHANE Chlorodimethylphenylsilane
Dichlorodiphenylsilane N,N-Dimethylformamide Methyl FELODIPINE IMP.C ( EP) :DIETHYL-4-(2,3-DICHLOROPHENYL)-2,6-DIMETHYL-1,4-DIHYDROPYRIDINE-3,5-DICARBOXYLATE Methyl bromide
FELODIPINE IMP.A ( EP) :ETHYL METHYL-4-(2,3-DICHLOROPHENYL)-2,6-DIMETHYLPYRIDINE-3,5-DICARBOXYLATE Bicalutamide (RS)-Felodipine,dl-Felodipine,Felodipine

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4-(2,3-DICHLOROPHENYL)-1,4-DIHYDRO-2,6-DIMETHYL-3,5-PYRIDINECARBOXYLIC ACID METHYL ESTER 4-(2,3-DICHLOROPHENYL)-1,4-DIHYDRO-2,6-DIMETHYL-3,5-PYRIDINEDICARBOXYLIC ACID METHYL ESTER FLODIL FELODAY ethyl methyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate Agon sr Brn 4331472 Felodipina 3-ethyl 5-Methyl (4R)-4-(2,3-dichlorophenyl)-2,6-diMethyl-1,4-dihydropyridine-3,5-dicarboxylate Felodipine iMpurity Felodipine Imp Felodipine 5-O-ethyl 3-O-methyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate Perfuda Perfudal 5-O-ethyl 3-O-methyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1 Felodipine Powder USP Standard 86189-69-7 Cell Biology Cell Signaling and Neuroscience Calcium Channel Modulators BioChemical Inhibitors and Activators Ion Channels Voltage-gated Ion Channels