ChemicalBook >> CAS DataBase List >>1-(4-Cyano-4-(4-fluorophenyl)cyclohexyl)-3-methyl-4-phenylpiperidine-4-carboxylic acid monohydrochloride

1-(4-Cyano-4-(4-fluorophenyl)cyclohexyl)-3-methyl-4-phenylpiperidine-4-carboxylic acid monohydrochloride

1-(4-Cyano-4-(4-fluorophenyl)cyclohexyl)-3-methyl-4-phenylpiperidine-4-carboxylic acid monohydrochloride structure

CAS No.: 79547-78-7

Chemical Name:: 1-(4-Cyano-4-(4-fluorophenyl)cyclohexyl)-3-methyl-4-phenylpiperidine-4-carboxylic acid monohydrochloride

Synonyms: 547;R50547;LEVOPHTA;LIVOSTIN;LEVOSTIN;Unii-124xma6yei;LEVOCABASTINE HCL;(3S,4R)-Cabastine;LIVOSTIN USP/EP/BP;(3S,4R)-Cabastine HCl

CBNumber:: CB6411376

Molecular Formula:: C26H30ClFN2O2

Molecular Weight:: 456.99

MDL Number:: MFCD07787408

MOL File:: 79547-78-7.mol

MSDS File:: SDS

Last updated:2024-10-28 23:16:16

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1-(4-Cyano-4-(4-fluorophenyl)cyclohexyl)-3-methyl-4-phenylpiperidine-4-carboxylic acid monohydrochloride Properties

storage temp.	2-8°C
solubility	DMSO: ~10 mg/mL, soluble
form	solid
color	white
FDA UNII	124XMA6YEI

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P264-P271-P280-P302+P352-P305+P351+P338

Hazard Codes

Risk Statements

36/37/38

Safety Statements

26-36

WGK Germany

HS Code

2933399090

NFPA 704

	0
2		0

1-(4-Cyano-4-(4-fluorophenyl)cyclohexyl)-3-methyl-4-phenylpiperidine-4-carboxylic acid monohydrochloride price More Price(12)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	1359856	Levocabastine hydrochloride United States Pharmacopeia (USP) Reference Standard	79547-78-7	50mg	$483	2024-03-01	Buy
Sigma-Aldrich	L3042	Levocabastine hydrochloride ≥99% (HPLC), solid	79547-78-7	5mg	$255	2023-06-20	Buy
Cayman Chemical	21014	Levocabastine (hydrochloride) ≥98%	79547-78-7	1mg	$32	2024-03-01	Buy
Cayman Chemical	21014	Levocabastine (hydrochloride) ≥98%	79547-78-7	5mg	$116	2024-03-01	Buy
Sigma-Aldrich	Y0001637	Levocabastine for system suitability 2 European Pharmacopoeia (EP) Reference Standard	79547-78-7	y0001637	$150	2024-03-01	Buy

Product number	Packaging	Price	Buy
1359856	50mg	$483	Buy
L3042	5mg	$255	Buy
21014	1mg	$32	Buy
21014	5mg	$116	Buy
Y0001637	y0001637	$150	Buy

1-(4-Cyano-4-(4-fluorophenyl)cyclohexyl)-3-methyl-4-phenylpiperidine-4-carboxylic acid monohydrochloride Chemical Properties,Uses,Production

Description

Levocabastine hydrochloride is a new, highly potent and specific histamine HI-receptor antagonist without anticholinergic or antiserotonergic side effects. It is reported to have both a fast onset and long duration of action. Indications are the treatment of allergic conjunctivitis and allergic rhinitis.

Chemical Properties

White or almost white powder.

Originator

Janssen (Johnson & Johnson) (U.S.A.)

Uses

A histamine H1 receptor antagonist used in allergic conjunctivitis.

Definition

ChEBI: Livostin (TN) is a member of piperidines.

Manufacturing Process

4-Cyano-4-(4-fluorophenyl)-heptanedioic acid diethyl ester is obtained by addition of ethyl acrylate to the anion from p-fluorophenylacetonitrile. By base catalyzed cyclization of these diester (sodium methoxide, 60°C, xylene) is synthesized an intermediate that after decarboethoxylation gives 1-(4- fluorophenyl)-4-oxycyclohexanecarbonitrile. By condensation of 3-methyl-5- phenylpiperidine-4-carboxylic acid benzyl ester and 1-(4-fluorophenyl)-4- oxycyclohexanecarbonitrile under reductive hydrogenation conditions (palladium-on-charcoal catalyst, 50°C, in ethanol) is prepared benzyl ester 4- piperidinecarboxylic acid, 1-(4-cyano-4-(4-fluorophenyl)cyclohexyl)-3-methyl- 4-phenyl-, (3S-(1(cis),3α,4β))-. The benzyl protecting group is then removed by hydrogenation method and 4-piperidinecarboxylic acid, 1-(4-cyano-4-(4- fluorophenyl)cyclohexyl)-3-methyl-4-phenyl-, (3S-(1(cis),3α,4β))- obtained is transformed into 4-piperidinecarboxylic acid, 1-(4-cyano-4-(4-fluorophenyl) cyclohexyl)-3-methyl-4-phenyl-, hydrochloride, (3S-(1(cis), 3α,4β))- (Levocabastine hydrochloride)

brand name

Livostin (Novartis).

Therapeutic Function

Antihistaminic

1-(4-Cyano-4-(4-fluorophenyl)cyclohexyl)-3-methyl-4-phenylpiperidine-4-carboxylic acid monohydrochloride Preparation Products And Raw materials

Raw materials

Ethyl acrylate Sodium Methoxide 4-Fluorophenylacetonitrile

Preparation Products

1-(4-Cyano-4-(4-fluorophenyl)cyclohexyl)-3-methyl-4-phenylpiperidine-4-carboxylic acid monohydrochloride Suppliers

Global( 75)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	32161	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1026@dideu.com	China	22787	58
Dayang Chem (Hangzhou) Co.,Ltd.	571-88938639 +8617705817739	info@dycnchem.com	China	52849	58
LEAP CHEM CO., LTD.	+86-852-30606658	market18@leapchem.com	China	24727	58
Hu Bei Jiutian Bio-medical Technology CO.,Ltd	027-88013699 17354350817	Ryan@jiutian-bio.com	China	6001	58
Shanghai Acmec Biochemical Technology Co., Ltd.	+undefined18621343501	product@acmec-e.com	China	33338	58
Aladdin Scientific	+1-+1(833)-552-7181	sales@aladdinsci.com	United States	52924	58
SHANGHAI KEAN TECHNOLOGY CO., LTD.	+8613817748580	cooperation@kean-chem.com	China	40066	58
Moxin Chemicals	+8617320513646	mike@molcoo.com	China	9483	58
DONBOO AMINO ACID COMPANY	+8613063595538	donboo@donboo.com	China	9363	58

Supplier	Advantage
TargetMol Chemicals Inc.	58
Dideu Industries Group Limited	58
Dayang Chem (Hangzhou) Co.,Ltd.	58
LEAP CHEM CO., LTD.	58
Hu Bei Jiutian Bio-medical Technology CO.,Ltd	58
Shanghai Acmec Biochemical Technology Co., Ltd.	58
Aladdin Scientific	58
SHANGHAI KEAN TECHNOLOGY CO., LTD.	58
Moxin Chemicals	58
DONBOO AMINO ACID COMPANY	58

View Lastest Price from 1-(4-Cyano-4-(4-fluorophenyl)cyclohexyl)-3-methyl-4-phenylpiperidine-4-carboxylic acid monohydrochloride manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2024-10-28	Levocabastine hydrochloride 79547-78-7	US $290.00-78.00 / mg			10g	TargetMol Chemicals Inc.
	2021-07-27	1-(4-Cyano-4-(4-fluorophenyl)cyclohexyl)-3-methyl-4-phenylpiperidine-4-carboxylic acid monohydrochloride USP/EP/BP 79547-78-7	US $1.10 / g	1g	99.9%	100 Tons min	Dideu Industries Group Limited

Levocabastine hydrochloride
79547-78-7
US $290.00-78.00 / mg
TargetMol Chemicals Inc.

1-(4-Cyano-4-(4-fluorophenyl)cyclohexyl)-3-methyl-4-phenylpiperidine-4-carboxylic acid monohydrochloride USP/EP/BP
79547-78-7
US $1.10 / g
99.9%
Dideu Industries Group Limited

79547-78-7(1-(4-Cyano-4-(4-fluorophenyl)cyclohexyl)-3-methyl-4-phenylpiperidine-4-carboxylic acid monohydrochloride)Related Search:

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6-[2-(4-IMIDAZOLYL)ETHYLAMINO]-N-(4-TRIFLUOROMETHYLPHENYL)HEPTANECARBOXAMIDE DIMALEATE thioperamide maleate salt (R)-(-)-α-Methylhistamine dihydrobromide 1-(4-FLUOROPHENYL)CYCLOHEXANECARBONITRILE 1-(4-Cyano-4-(4-fluorophenyl)cyclohexyl)-3-methyl-4-phenylpiperidine-4-carboxylic acid monohydrochloride

LEVOCABASTINE 1-ISOPROPYL-PIPERIDINE-4-CARBOXYLIC ACID HYDROCHLORIDE 4-PHENYL-4-PIPERIDINE CARBOXYLIC ACID

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1-(4-Cyano-4-(4-fluorophenyl)cyclohexyl)-3-methyl-4-phenylpiperidine-4-carboxylic acid monohydrochloride R50547 LIVOSTIN [3s-[1(cis),3α,4β]]-1-[4-cyano-4-(4-fluorophenyl)cyclohexyl]-3-methyl-4-phenyl-4-piperidinecarboxylic acid 4-Piperidinecarboxylic acid, 1-[4-cyano-4-(4-fluorophenyl)cyclohexyl]-3-methyl-4-phenyl-, monohydrochloride, [3S-[1(cis),3a,4b]]- 4-Piperidinecarboxylic acid, 1-[cis-4-cyano-4-(4-fluorophenyl)cyclohexyl]-3-methyl-4-phenyl-, monohydrochloride, (3S,4R)- (9CI) Levophta, Levostin, R50547, [3S-[1(cis),3α,4β]]-1-[4-cyano-4-(4-fluorophenyl)cyclohexyl]-3-methyl-4-phenyl-4-piperidinecarboxylic acid LEVOPHTA LEVOCABASTINE HCL LEVOCABASTINE HYDROCHLORIDE LEVOSTIN [3S-[1(CIS),3ALPHA,4BETA]]-1-[4-CYANO-4-(4-FLUOROPHENYL)CYCLOHEXYL]-3-METHYL-4-PHENYL-4-PIPERIDINECARBOXYLIC ACID HYDROCHLORIDE 4-Piperidinecarboxylic acid, 1-(cis-4-cyano-4-(4-fluorophenyl)cyclohexyl)-3-methyl-4-phenyl-, monohydrochloride, (3S,4R)- Unii-124xma6yei (3S,4R)-Cabastine Levocabastine Hydrochloride (50 mg) (3S,4R)-Cabastine Hydrochloride Levocabastine for system suitability 2 Levocabastine for system suitability 1 CRS Levocabastine hydrochloride CRS Levocabastine for system suitability 2 CRS (3S,4R)-1-[cis-4-Cyano-4-(4-fluorophenyl)cyclohexyl]- 3-methyl-4-phenylpiperidine-4-carboxylic acid monohydrochloride LIVOSTIN USP/EP/BP 1-(4-Cyano-4-(4-fluorophenyl)cyclohexyl)-3-methyl-4-phenylpiperidine-4-carboxylic acid monohydrochloride USP/EP/BP Levocabastine Hydrochloride (1359856) 547 (3S,4R)-1-[4-cyano-4-(4-fluorophenyl)cyclohexyl]-3-methyl-4-phenylpiperidine-4-carboxylicacid,hydrochloride (3S,4R)-Cabastine HCl 4-Piperidinecarboxylicacid, 1-[cis-4-cyano-4-(4-fluorophenyl)cyclohexyl]-3-methyl-4-phenyl-,hydrochloride (1:1), (3S,4R)- 79547-78-7 C26H30ClFN2O2 C26H29N2O2FHCl C26H29FN2O2HCl Aromatics Chiral Reagents Heterocycles Intermediates & Fine Chemicals Pharmaceuticals