LEVOCABASTINE
- CAS No.
- 79516-68-0
- Chemical Name:
- LEVOCABASTINE
- Synonyms
- Bilina;ALKN006000;Levocabastin;LEVOCABASTINE;Levocabastina;Levocabastinum;Unii-H68bp06S81;Levocabastinum [latin];Levocabastina [spanish];Levocabastine [inn:ban]
- CBNumber:
- CB2307787
- Molecular Formula:
- C26H29FN2O2
- Molecular Weight:
- 420.52
- MDL Number:
- MFCD00672639
- MOL File:
- 79516-68-0.mol
Boiling point | 589.9±50.0 °C(Predicted) |
---|---|
Density | 1.23 |
pka | 3.57±0.40(Predicted) |
FDA UNII | H68BP06S81 |
ATC code | R01AC02,S01GX02 |
LEVOCABASTINE Chemical Properties,Uses,Production
Originator
Livostin,Janssen-Cilag,Belgium
Uses
Anti histaminic.
Definition
ChEBI: Levocabastine is a member of piperidines.
Manufacturing Process
4-Cyano-4-(4-fluorophenyl)-heptanedioic acid diethyl ester is obtained by addition of ethyl acrylate to the anion from p-fluorophenylacetonitrile. By base catalyzed cyclization of these diester (sodium methoxide, 60°C, xylene) is synthesized an intermediate that after decarboethoxylation gives 1-(4- fluorophenyl)-4-oxycyclohexanecarbonitrile. By condensation of 3-methyl-5- phenylpiperidine-4-carboxylic acid benzyl ester and 1-(4-fluorophenyl)-4- oxycyclohexanecarbonitrile under reductive hydrogenation conditions (palladium-on-charcoal catalyst, 50°C, in ethanol) is prepared benzyl ester 4- piperidinecarboxylic acid, 1-(4-cyano-4-(4-fluorophenyl)cyclohexyl)-3-methyl- 4-phenyl-, (3S-(1(cis),3α,4β))-. The benzyl protecting group is then removed by hydrogenation method and 4-piperidinecarboxylic acid, 1-(4-cyano-4-(4- fluorophenyl)cyclohexyl)-3-methyl-4-phenyl-, (3S-(1(cis),3α,4β))- obtained is transformed into 4-piperidinecarboxylic acid, 1-(4-cyano-4-(4-fluorophenyl) cyclohexyl)-3-methyl-4-phenyl-, hydrochloride, (3S-(1(cis), 3α,4β))- (Levocabastine hydrochloride)
brand name
Livostin (Novartis).
Therapeutic Function
Antihistaminic
LEVOCABASTINE Preparation Products And Raw materials
LEVOCABASTINE Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49391 | 58 |
Shaanxi Dideu Medichem Co. Ltd | +86-29-87569265 +86-18612256290 | 1056@dideu.com | China | 2132 | 58 |
Shaanxi Dideu Medichem Co. Ltd | +86-029-89586680 +86-18192503167 | 1026@dideu.com | China | 9030 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
Hu Bei Jiutian Bio-medical Technology CO.,Ltd | 027-88013699 17354350817 | Ryan@jiutian-bio.com | China | 7431 | 58 |
LGM Pharma | 1-(800)-881-8210 | inquiries@lgmpharma.com | United States | 2127 | 70 |
BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 14059 | 65 |
ShangHai Caerulum Pharma Discovery Co., Ltd. | 18149758185 | sales-cpd@caerulumpharma.com | China | 3465 | 58 |
BOC Sciences | 16314854226 | info@bocsci.com | United States | 9926 | 65 |
TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 23963 | 58 |
View Lastest Price from LEVOCABASTINE manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
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2021-07-20 | Levocabastine
79516-68-0
|
US $1.00-1.00 / KG | 1g | 99% | 50tons | Shaanxi Dideu Medichem Co. Ltd |
-
- Levocabastine
79516-68-0
- US $1.00-1.00 / KG
- 99%
- Shaanxi Dideu Medichem Co. Ltd
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