6-DIAZO-5-OXO-L-NORLEUCINE
- CAS No.
- 157-03-9
- Chemical Name:
- 6-DIAZO-5-OXO-L-NORLEUCINE
- Synonyms
- DON;L-DON;D2141;NSC-7365;H-L-Don-OH;don(pharmaceutical);diazo-oxo-norleucine;H-6-DIAZO-5-OXO-NLE-OH;H-NLE(6-DIAZO-5-OXO)-OH;L-Nle(6-Diazo-5-oxo)-OH
- CBNumber:
- CB6413936
- Molecular Formula:
- C6H9N3O3
- Molecular Weight:
- 171.15
- MDL Number:
- MFCD00037218
- MOL File:
- 157-03-9.mol
| Melting point | 145 °C |
|---|---|
| Boiling point | 301.12°C (rough estimate) |
| Density | 1.3994 (rough estimate) |
| refractive index | 1.5800 (estimate) |
| storage temp. | -20°C |
| solubility | DMSO (Slightly, Heated, Sonicated), Water (Slightly) |
| form | crystalline |
| color | light yellow |
| Merck | 13,3026 |
| BRN | 1725815 |
| Stability | Hygroscopic |
| InChI | InChI=1/C6H9N3O3/c7-5(6(11)12)2-1-4(10)3-9-8/h3,5H,1-2,7H2,(H,11,12)/t5-/s3 |
| InChIKey | YCWQAMGASJSUIP-GQMHJJTINA-N |
| SMILES | C(C(=O)C=[N+]=[N-])C[C@H](N)C(=O)O |&1:7,r| |
| FDA UNII | 03J0H273KZ |
| NCI Drug Dictionary | diazooxonorleucine |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301+H311+H331 | |||||||||
| Precautionary statements | P261-P264-P280-P301+P310-P302+P352+P312-P304+P340+P311 | |||||||||
| Hazard Codes | T | |||||||||
| Risk Statements | 23/24/25 | |||||||||
| Safety Statements | 36/37/39-45 | |||||||||
| RIDADR | UN 2811 6.1/PG 3 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | RC6340000 | |||||||||
| F | 8 | |||||||||
| NFPA 704 |
|
6-DIAZO-5-OXO-L-NORLEUCINE price More Price(23)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | D2141 | 6-Diazo-5-oxo-L-norleucine crystalline | 157-03-9 | 5mg | $71.1 | 2024-03-01 | Buy |
| Sigma-Aldrich | D2141 | 6-Diazo-5-oxo-L-norleucine crystalline | 157-03-9 | 25mg | $246 | 2024-03-01 | Buy |
| Cayman Chemical | 17580 | 6-diazo-5-oxo-L-nor-Leucine ≥95% | 157-03-9 | 5mg | $49 | 2024-03-01 | Buy |
| Cayman Chemical | 17580 | 6-diazo-5-oxo-L-nor-Leucine ≥95% | 157-03-9 | 10mg | $92 | 2024-03-01 | Buy |
| Cayman Chemical | 17580 | 6-diazo-5-oxo-L-nor-Leucine ≥95% | 157-03-9 | 25mg | $213 | 2024-03-01 | Buy |
6-DIAZO-5-OXO-L-NORLEUCINE Chemical Properties,Uses,Production
Chemical Properties
Slightly yellow powder
Uses
6-Diazo-5-oxo-L-norleucine (DON) has been used as an inhibitor of glutamine synthetase–glutamine(amide)-2-oxoglutarate aminotransferase.
Definition
ChEBI: 6-diazo-5-oxo-L-norleucine is a non-proteinogenic L-alpha-amino acid that is L-norleucine which is substituted at position 5 by an oxo group and at position 6 by a diazo group. It is as inhibitor of various glutamine-utilising enzymes. It has a role as a bacterial metabolite, an analgesic, an antibacterial agent, an antiviral agent, an antineoplastic agent, an EC 6.3.5.5 [carbamoyl-phosphate synthase (glutamine-hydrolysing)] inhibitor, an EC 6.3.4.2 [CTP synthase (glutamine hydrolyzing)] inhibitor, an EC 6.3.5.3 (phosphoribosylformylglycinamidine synthase) inhibitor, an EC 6.3.5.2 [GMP synthase (glutamine-hydrolysing)] inhibitor, an antimetabolite, a glutamine antagonist, an apoptosis inducer, an EC 2.4.2.14 (amidophosphoribosyltransferase) inhibitor, an EC 3.5.1.2 (glutaminase) inhibitor, an EC 6.3.5.1 [NAD(+) synthase (glutamine-hydrolysing)] inhibitor and an EC 6.3.5.4 [asparagine synthase (glutamine-hydrolysing)] inhibitor. It is a non-proteinogenic L-alpha-amino acid, a diazo compound and a ketone. It is a tautomer of a 6-diazo-5-oxo-L-norleucine zwitterion.
General Description
Chemical structure: amino acid derivatives
Biochem/physiol Actions
DON is used to study mechanisms of glutamine utilizing enzymes such as carbamoyl phosphate synthase and cytidine triphosphate synthase.
Purification Methods
Crystallise it from EtOH, H2O/EtOH, MeOH, 95% aqueous MeOH or H2O/Me2CO. [DeWald & Moor J Am Chem Soc 80 3944 1958, Dion et al. J Am Chem Soc 78 3075 1956, Beilstein 4 IV 3278.]
6-DIAZO-5-OXO-L-NORLEUCINE Preparation Products And Raw materials
Raw materials
Preparation Products
6-DIAZO-5-OXO-L-NORLEUCINE Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32957 | 60 |
| Shaanxi Dideu Medichem Co. Ltd | +86-029-81138252 +86-18789408387 | 1057@dideu.com | China | 3958 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-29-81148696 +86-15536356810 | 1022@dideu.com | China | 3882 | 58 |
| Hebei Yanxi Chemical Co., Ltd. | +8617531190177 | peter@yan-xi.com | China | 5857 | 58 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22963 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32165 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6312 | 58 |
| BOC Sciences | 16314854226; +16314854226 | inquiry@bocsci.com | United States | 19741 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10473 | 58 |
| Nextpeptide Inc | +86-0571-81612335 +8613336028439 | sales@nextpeptide.com | China | 19908 | 58 |
View Lastest Price from 6-DIAZO-5-OXO-L-NORLEUCINE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-11-19 | 6-Diazo-5-oxo-L-nor-Leucine
157-03-9
|
US $40.00-183.00 / mg | 98.93% | 10g | TargetMol Chemicals Inc. | ||
 |
2024-10-25 | 6-Diazo-5-oxo-L-norleucine
157-03-9
|
US $40.00 / kg | 1kg | 0.99 | 10 tons | Hebei Yanxi Chemical Co., Ltd. | |
 |
2024-07-14 | 6-Diazo-5-oxo-l-norleucine
157-03-9
|
US $0.10 / KG | 1KG | 99.0% | 1000Tons | Shaanxi Dideu Medichem Co. Ltd |
-
- 6-Diazo-5-oxo-L-nor-Leucine
157-03-9
- US $40.00-183.00 / mg
- 98.93%
- TargetMol Chemicals Inc.
-
- 6-Diazo-5-oxo-L-norleucine
157-03-9
- US $40.00 / kg
- 0.99
- Hebei Yanxi Chemical Co., Ltd.
-
- 6-Diazo-5-oxo-l-norleucine
157-03-9
- US $0.10 / KG
- 99.0%
- Shaanxi Dideu Medichem Co. Ltd