6-[1-(3,5,5,8,8-PENTAMETHYL-5,6,7,8-TETRAHYDRO-NAPHTHALEN-2-YL)-CYCLOPROPYL]-NICOTINIC ACID
![6-[1-(3,5,5,8,8-PENTAMETHYL-5,6,7,8-TETRAHYDRO-NAPHTHALEN-2-YL)-CYCLOPROPYL]-NICOTINIC ACID Structure](CAS/GIF/153559-76-3.gif)
- CAS No.
- 153559-76-3
- Chemical Name:
- 6-[1-(3,5,5,8,8-PENTAMETHYL-5,6,7,8-TETRAHYDRO-NAPHTHALEN-2-YL)-CYCLOPROPYL]-NICOTINIC ACID
- Synonyms
- LG 268;CD 3127;lg100268;ALRT 268;LGD 1268;AGN 192620;LGD 100268;hthalenyl)cyclopropyl)-;3-pyridinecarboxylicacid,6-(1-(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-nap;6-[1-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)cyclopropyl]nicotinic Acid
- CBNumber:
- CB6458625
- Molecular Formula:
- C24H29NO2
- Molecular Weight:
- 363.49
- MDL Number:
- MFCD01758574
- MOL File:
- 153559-76-3.mol
- MSDS File:
- SDS
6-[1-(3,5,5,8,8-PENTAMETHYL-5,6,7,8-TETRAHYDRO-NAPHTHALEN-2-YL)-CYCLOPROPYL]-NICOTINIC ACID Properties
| Melting point | 275-277°C |
|---|---|
| Boiling point | 487.0±33.0 °C(Predicted) |
| Density | 1.115±0.06 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | DMSO: ≥5mg/mL (warmed) |
| pka | 2.35±0.10(Predicted) |
| form | powder |
| color | white to beige |
| FDA UNII | UVU4X1103P |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
6-[1-(3,5,5,8,8-PENTAMETHYL-5,6,7,8-TETRAHYDRO-NAPHTHALEN-2-YL)-CYCLOPROPYL]-NICOTINIC ACID price More Price(18)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML0279 | LG100268 ≥98% (HPLC) | 153559-76-3 | 5mg | $144 | 2024-03-01 | Buy |
| Sigma-Aldrich | SML0279 | LG100268 ≥98% (HPLC) | 153559-76-3 | 25mg | $568 | 2024-03-01 | Buy |
| Cayman Chemical | 21606 | LG 100268 ≥98% | 153559-76-3 | 1mg | $44 | 2024-03-01 | Buy |
| Cayman Chemical | 21606 | LG 100268 ≥98% | 153559-76-3 | 5mg | $118 | 2024-03-01 | Buy |
| Cayman Chemical | 21606 | LG 100268 ≥98% | 153559-76-3 | 10mg | $214 | 2024-03-01 | Buy |
6-[1-(3,5,5,8,8-PENTAMETHYL-5,6,7,8-TETRAHYDRO-NAPHTHALEN-2-YL)-CYCLOPROPYL]-NICOTINIC ACID Chemical Properties,Uses,Production
Chemical Properties
Off-White Solid
Uses
LG 100268 is a potent RXR agonist for evaluation in the treatment of non-insulin-dependent (type II) diabetes mellitus (NIDDM).
Biochem/physiol Actions
LG100268 (LG268) is a potent and selective rexinoid and retinoid-X receptor (RXR) agonist. LG100268 binds to the α, β and γ RXR receptors with an IC50 = 3-4 nM and has no activity at the RAR retinoic acid receptors.
in vivo
LG100268 (oral diet; 100 mg/kg; once daily; 7 weeks) combines with C/P presents a more markedly reduced average tumor burden than LG268 or C/P alone. The combination establish a reduced lung tumors, which represents a reduction of 82% (vs. 59%-67% with the single drugs) in comparison with the controls[3].
| Animal Model: | A/J mice[3] |
| Dosage: | 50 mg/kg (Combines with carboplatin (50 mg/kg i.p.) starts 1 week after the LG268 treatment diet) |
| Administration: | Oral diet; once daily; 7 weeks |
| Result: | Decreased lung tumors growth significantly in mice. |
storage
Store at -20°C
6-[1-(3,5,5,8,8-PENTAMETHYL-5,6,7,8-TETRAHYDRO-NAPHTHALEN-2-YL)-CYCLOPROPYL]-NICOTINIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
6-[1-(3,5,5,8,8-PENTAMETHYL-5,6,7,8-TETRAHYDRO-NAPHTHALEN-2-YL)-CYCLOPROPYL]-NICOTINIC ACID Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19552 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32202 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30230 | 58 |
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38636 | 58 | |
| J & K SCIENTIFIC LTD. | 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32321 | 50 |
| Shanghai Ennopharm Co., Ltd. | +86 (21) 6435-5022 | China | 4267 | 65 | |
| Nanjing Norris-Pharm Technology Co., Ltd | 13901585132 | 799750417@qq.com | China | 8878 | 55 |
| AdooQ BioScience, LLC | +1 (866) 930-6790 | info@adooq.com | United States | 2782 | 58 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51456 | 80 |
