PFM01
- CAS No.
- 1558598-41-6
- Chemical Name:
- PFM01
- Synonyms
- PFM01;PFM01 >=98% (HPLC);(Z)-5-(4-Hydroxybenzylidene)-3-isobutyl-2-thioxothiazolidin-4-one;(5Z)-5-[(4-Hydroxyphenyl)methylene]-3-(2-methylpropyl)-2-thioxo-4-thiazolidinone;4-Thiazolidinone, 5-[(4-hydroxyphenyl)methylene]-3-(2-methylpropyl)-2-thioxo-, (5Z)-;Inhibitor,derivative,MRE11,PFM-01,NHEJ,Mirin,DSB,endonuclease,N-alkylated,PFM01,PFM 01,inhibit
- CBNumber:
- CB64670537
- Molecular Formula:
- C14H15NO2S2
- Molecular Weight:
- 293.4
- MDL Number:
- MFCD02220972
- MOL File:
- 1558598-41-6.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
Symbol(GHS) | ![]() GHS07 |
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---|---|---|---|---|---|---|---|---|---|---|
Signal word | Warning | |||||||||
Hazard statements | H302-H315-H319 | |||||||||
Precautionary statements | P301+P312+P330-P305+P351+P338 | |||||||||
NFPA 704 |
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PFM01 price More Price(11)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | SML1735 | PFM01 ≥98% (HPLC) | 1558598-41-6 | 5mg | $114 | 2024-03-01 | Buy |
Sigma-Aldrich | SML1735 | PFM01 ≥98% (HPLC) | 1558598-41-6 | 25mg | $464 | 2024-03-01 | Buy |
Tocris | 6222 | PFM01 ≥98%(HPLC) | 1558598-41-6 | 50 | $315 | 2021-12-16 | Buy |
Tocris | 6222 | PFM01 ≥98%(HPLC) | 1558598-41-6 | 10 | $75 | 2021-12-16 | Buy |
TRC | P293993 | PFM01 | 1558598-41-6 | 1mg | $45 | 2021-12-16 | Buy |
PFM01 Chemical Properties,Uses,Production
Biochem/physiol Actions
PFM01 is a cell-permeable N-alkylated Mirin (Sigma Cat. No. 475954) derivative that selectively inhibits against MRE11 endo-, but not exo-, nuclease activity. PFM01 targets MRE11 at a site near the dimer interface, distinct from that occupied by Mirin and PFM39 to allow disruption of the ssDNA-binding groove and selective inhibition against MRE11 endo-, but not exo-, nuclease activity. While both endonuclease and exonuclease activities are required for MRE11-mediated homologous recombination (HR) repair, only FM01 (100 μM), but not the exonuclease inhibitors Mirin (500 μM) and PFM39 (100 μM), rescues G2-phase double-strand break (DSB) repair defect in HR protein BRCA2-deficient HSC62-hTERT fibroblasts following ionizing irradiation (IR) by blocking HR initiation and thereby allowing non-homologous end joining (NHEJ) to proceed.
storage
Store at -20°C
PFM01 Preparation Products And Raw materials
Raw materials
Preparation Products
PFM01 Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
Labnetwork lnc. | +86-27-50766799 +8618062016861 | contact@labnetwork.com | China | 19994 | 58 |
InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43348 | 58 |
Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51471 | 80 |
Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9707 | 58 |
Tianjin Kailiqi Biotechnology Co., Ltd. | 15076683720 | klq@cw-bio.com | China | 3770 | 55 |
ShangHai Biochempartner Co.,Ltd | 17754423994 17754423994 | 2853530910@QQ.com | China | 8017 | 62 |