ChemicalBook >> CAS DataBase List >>L-Glutamic acid γ-(4-nitroanilide)
L-Glutamic acid γ-(4-nitroanilide)
- CAS No.
- 7300-59-6
- Chemical Name:
- L-Glutamic acid γ-(4-nitroanilide)
- Synonyms
- UTAMYL;GLU-PNA;Glu-4NA;ST5307107;110893-27-1;G1135_SIGMA;-p-NITROANIL;H-GLU(PNA)-OH;GPNA/H-Glu-PNA;EINECS 230-748-5
- CBNumber:
- CB6496764
- Molecular Formula:
- C11H13N3O5
- Molecular Weight:
- 267.24
- MDL Number:
- MFCD00036218
- MOL File:
- 7300-59-6.mol
- MSDS File:
- SDS
Last updated:2024-12-18 14:08:57
| Melting point | 185-188°C |
|---|---|
| alpha | [α]D20 +36～+39°(c=2,dil.HCl) |
| Boiling point | 590.6±50.0 °C(Predicted) |
| Density | 1.463 |
| refractive index | 32 ° (C=2, 0.5mol/L HCl) |
| storage temp. | 2-8°C |
| solubility | Aqueous Acid (Slightly) |
| form | Solid |
| pka | 2.21±0.10(Predicted) |
| color | White to Pale Yellow |
| BRN | 2818758 |
| InChI | InChI=1S/C11H13N3O5/c12-10(15)6-5-9(11(16)17)13-7-1-3-8(4-2-7)14(18)19/h1-4,9,13H,5-6H2,(H2,12,15)(H,16,17)/t9-/m0/s1 |
| InChIKey | IMTMBDXEKMXETQ-VIFPVBQESA-N |
| SMILES | C(O)(=O)[C@H](CCC(N)=O)NC1=CC=C([N+]([O-])=O)C=C1 |
| CAS DataBase Reference | 7300-59-6(CAS DataBase Reference) |
| FDA UNII | 81SZ84NXWS |
| EPA Substance Registry System | L-Glutamine, N-(4-nitrophenyl)- (7300-59-6) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P305+P351+P338 | |||||||||
| Safety Statements | 22-24/25 | |||||||||
| WGK Germany | 3 | |||||||||
| TSCA | Yes | |||||||||
| HS Code | 29242990 | |||||||||
| NFPA 704 |
|
L-Glutamic acid γ-(4-nitroanilide) price More Price(25)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | G1135 | L-Glutamic acid γ-(4-nitroanilide) γ-glutamyl transpeptidase substrate | 7300-59-6 | 1g | $107 | 2024-03-01 | Buy |
| Sigma-Aldrich | G1135 | L-Glutamic acid γ-(4-nitroanilide) γ-glutamyl transpeptidase substrate | 7300-59-6 | 5g | $426 | 2024-03-01 | Buy |
| TCI Chemical | G0065 | L-gamma-Glutamyl-p-nitroanilide Monohydrate >98.0%(HPLC)(T) | 7300-59-6 | 1g | $122 | 2024-03-01 | Buy |
| TCI Chemical | G0065 | L-gamma-Glutamyl-p-nitroanilide Monohydrate >98.0%(HPLC)(T) | 7300-59-6 | 5g | $412 | 2024-03-01 | Buy |
| Alfa Aesar | A14442 | gamma-L-Glutamyl-4-nitroanilide, 98+% | 7300-59-6 | 5g | $184 | 2021-12-16 | Buy |
L-Glutamic acid γ-(4-nitroanilide) Chemical Properties,Uses,Production
Description
L-Glutamic acid γ-(4-nitroanilide) is a substrate for γ-glutamyltransferase (GGT). It is an important enzyme that is widely used in biocatalysis and clinical diagnostics.
Chemical Properties
cream coloured to light yellow powder
Uses
Substrate for gamma-glutamyl transpeptidase
Preparation
To a microwave vial containing a solution of Boc-L-glutamic acid tert-butyl ester (0.165 mmol, 1.0 equiv) and HATU (0.165 mmol, 1.0 equiv) in DMF (1.65 mL) was added the amine followed by DIPEA (57.5 μL, 2.0 equiv). The vial was sealed and heated under microwave irradiation for 30 min at 120 °C. Upon completion, the reaction was partitioned between water and CH2Cl2, extracted 3× with CH2Cl2, dried over anhydrous Na2SO4, and concentrated under vacuum. Compounds were purified via reverse phase chromatography (5-95% acetonitrile/water) to afford the N-Boc-glutamylanilide-tert-butyl esters. The compounds were transferred to vials followed by the addition of 2.0 mL of 4.0 M HCl in dioxane. The reaction stirred at 40 °C for 4 h. The reactions were concentrated under vacuum to afford L-Glutamic acid γ-(4-nitroanilide).
Solubility in water
Soluble in water, formic acid (50 mg/ml), and 0.5mol/l hydrochloric acid. Chloroform: Slightly soluble. DMF: Slightly soluble. DMSO: Slightly soluble. Ethanol: Slightly soluble. Methanol: Slightly soluble. PBS (pH 7.2): Slightly soluble
Synthesis of L-Glutamic acid γ-(4-nitroanilide) from 3-Oxazolidinecarboxylic acid, 4-[3-[(4-nitrophenyl)amino]-3-oxopropyl]-5-oxo-, phenylmethyl ester, (4S)-
L-Glutamic acid γ-(4-nitroanilide) Preparation Products And Raw materials
L-Glutamic acid γ-(4-nitroanilide) Suppliers
Global( 127)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| BOC Sciences | 16314854226; +16314854226 | inquiry@bocsci.com | United States | 19741 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49374 | 58 |
| SIMAGCHEM CORP | +86-13806087780 | sale@simagchem.com | China | 17365 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 | sales@tnjchem.com | China | 34563 | 58 |
| ANHUI WITOP BIOTECH CO., LTD | +8615255079626 | eric@witopchemical.com | China | 23541 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | 571-88938639 +8617705817739 | info@dycnchem.com | China | 52849 | 58 |
| Nextpeptide Inc | +86-0571-81612335 +8613336028439 | sales@nextpeptide.com | China | 19908 | 58 |
| GIHI CHEMICALS CO.,LIMITED | +8618058761490 | info@gihichemicals.com | China | 49978 | 58 |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43340 | 58 |
| Supplier | Advantage |
|---|---|
| BOC Sciences | 58 |
| Alchem Pharmtech,Inc. | 58 |
| CONIER CHEM AND PHARMA LIMITED | 58 |
| SIMAGCHEM CORP | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | 58 |
| ANHUI WITOP BIOTECH CO., LTD | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | 58 |
| Nextpeptide Inc | 58 |
| GIHI CHEMICALS CO.,LIMITED | 58 |
| LEAPCHEM CO., LTD. | 58 |
7300-59-6(L-Glutamic acid γ-(4-nitroanilide))Related Search:
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110893-27-1
EINECS 230-748-5
G1135_SIGMA
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