ENNIATIN FROM MICROBIAL SOURCE
- CAS No.
- 11113-62-5
- Chemical Name:
- ENNIATIN FROM MICROBIAL SOURCE
- Synonyms
- Enniatin coMplex;Enniatin microbial;ENNIATIN FROM MICROBIAL SOURCE;(3S,6R,9S,12R,15S,18R)-3,9,15-tri(butan-2-yl)-4,10,16-trimethyl-6,12,18-tri(propan-2-yl)-1,7,13-trioxa-4,10,16-triazacyclooctadecane-2,5,8,11,14,17-hexone
- CBNumber:
- CB6503437
- Molecular Formula:
- C36H63N3O9.C35H61N3O9.C34H59N3O9.C33H57N3O9
- Molecular Weight:
- 2643.46
- MDL Number:
- MFCD00214209
- MOL File:
- 11113-62-5.mol
SAFETY
Risk and Safety Statements
Symbol(GHS) | ![]() GHS06 |
---|---|
Signal word | Danger |
Hazard statements | H301+H311+H331 |
Precautionary statements | P312-P260-P280 |
Hazard Codes | T |
Risk Statements | 23/24/25 |
Safety Statements | 22-36/37/39-45 |
RIDADR | 2811 |
HazardClass | 6.1(a) |
PackingGroup | I |
HS Code | 2934999090 |
ENNIATIN FROM MICROBIAL SOURCE price More Price(10)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Cayman Chemical | 9002040 | Enniatin Complex ≥95% | 11113-62-5 | 10mg | $353 | 2024-03-01 | Buy |
Cayman Chemical | 9002040 | Enniatin Complex ≥95% | 11113-62-5 | 50mg | $1057 | 2024-03-01 | Buy |
TRC | E556028 | Enniatincomplex | 11113-62-5 | 5mg | $475 | 2021-12-16 | Buy |
Usbiological | E3222-30 | Enniatin complex | 11113-62-5 | 10mg | $523 | 2021-12-16 | Buy |
TRC | E556028 | Enniatincomplex | 11113-62-5 | 10mg | $660 | 2021-12-16 | Buy |
ENNIATIN FROM MICROBIAL SOURCE Chemical Properties,Uses,Production
Uses
Enniatin complex is a complex mixture of Fusarium produced depsipeptide ionophores.This compound can be used to control contamination in fermentation of gaseous substrates.
Uses
Enniatins are a complex of depsipeptides produced by several Fusarium species. Typically, the complex contains 4 major components: A, A1, B and B1 together with minor amounts of enniatins C, D, E and F. The enniatins act as ionophores. Recently their effects on acyl-CoA cholesterol transferase, as nematocides and the selectivity of their antitumour action have received more focus.
Biological Activity
enniatins, analogues of beauvericin, is a regular cyclic hexadepsipeptide isolated from fusarium species of fungis, also they have been isolated from other genera, such as verticillium and halosarpheia [1]. they have been involved in many biological activities, such as antiinsectan, antifungal, antibiotic and cytotoxic [1].
in vitro
fusafungine is a mixture of several enniatins with bacteriostatic activity against most micro-organisms responsible for infections and superinfections of the respiratory tract. fusafungine has been developed for treatment of upper respiratory tract infections by oral and/or nasal inhalation. fusafungine in low concentrations down-regulated the expression of intercellular adhesion molecule-1 (icam-1) by activated macrophages, inhibited the production of the proinflammatory cytokines il-1, tnfα and il-6 and inhibited the release of oxygen free radicals by inflammatory macrophages without altering their phagocytic activity. fusafungine also inhibited t-cell activation and proliferation, and the synthesis of ifn-γ by activated t cells [2]. exposure 8 h to enniatins at nanomolar concentrations significantly stimulated cell proliferation. at low micromolar concentrations, enniatins exihibited profound apoptosis-inducing effects against various human cancer cell types. in the fluorescence-activated cell sorting analysis, enniatins induced cell cycle arrest in the g0/g1 phase. in human cancer cells, elevated enn concentrations induced profound p53-dependent cytostatic and p53-independent cytotoxic activities [3]. enniatin easily incorporated into the cell membrane in which it formed cation-selective pores [4].
Purification Methods
It is a cyclic peptidic ester antibiotic which is recrystallised from EtOH/water but is deactivated in alkaline solution. [Ovchinnikov & Ivanov in The Proteins (Neurath and Hill eds) Academic Press, NY, Vol V pp. 365 and 516 1982, Tomeda et al. J Antibiot 45 1626 1992.]
References
[1] sy-cordero a a, pearce c j, oberlies n h. revisiting the enniatins: a review of their isolation, biosynthesis, structure determination and biological activities[j]. the journal of antibiotics, 2012, 65(11): 541-549.
[2] german-fattal m. fusafungine, an antimicrobial with anti-inflammatory properties in respiratory tract infections[j]. clinical drug investigation, 2001, 21(9): 653-670.
[3] dornetshuber r, heffeter p, kamyar m r, et al. enniatin exerts p53-dependent cytostatic and p53-independent cytotoxic activities against human cancer cells[j]. chemical research in toxicology, 2007, 20(3): 465-473.
[4] kamyar m, rawnduzi p, studenik c r, et al. investigation of the electrophysiological properties of enniatins[j]. archives of biochemistry and biophysics, 2004, 429(2): 215-223.
ENNIATIN FROM MICROBIAL SOURCE Preparation Products And Raw materials
Raw materials
Preparation Products
ENNIATIN FROM MICROBIAL SOURCE Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32836 | 60 |
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
BOC Sciences | 16314854226; +16314854226 | inquiry@bocsci.com | United States | 19743 | 58 |
Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 18892239720 | psaitong@jm-bio.com | China | 12308 | 58 |
Lynnchem | 86-(0)29-85992781 17792393971 | info@lynnchem.com | China | 4587 | 58 |
Novachemistry | 44-20819178-90 02081917890 | info@novachemistry.com | United Kingdom | 4381 | 58 |
Shenzhen Polymeri Biochemical Technology Co., Ltd. | +86-400-002-6226 | sales@rrkchem.com | China | 56077 | 58 |
BOC Sciences | -- | info@bocsci.com | USA | 0 | 65 |
ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11289 | 58 |