ENNIATIN FROM MICROBIAL SOURCE
- CAS No.
- 11113-62-5
- Chemical Name:
- ENNIATIN FROM MICROBIAL SOURCE
- Synonyms
- Enniatin coMplex;Enniatin microbial;ENNIATIN FROM MICROBIAL SOURCE;(3S,6R,9S,12R,15S,18R)-3,9,15-tri(butan-2-yl)-4,10,16-trimethyl-6,12,18-tri(propan-2-yl)-1,7,13-trioxa-4,10,16-triazacyclooctadecane-2,5,8,11,14,17-hexone
- CBNumber:
- CB6503437
- Molecular Formula:
- C36H63N3O9.C35H61N3O9.C34H59N3O9.C33H57N3O9
- Molecular Weight:
- 2643.46
- MDL Number:
- MFCD00214209
- MOL File:
- 11113-62-5.mol
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|---|---|
| Signal word | Danger |
| Hazard statements | H301+H311+H331 |
| Precautionary statements | P312-P260-P280 |
| Hazard Codes | T |
| Risk Statements | 23/24/25 |
| Safety Statements | 22-36/37/39-45 |
| RIDADR | 2811 |
| HazardClass | 6.1(a) |
| PackingGroup | I |
| HS Code | 2934999090 |
ENNIATIN FROM MICROBIAL SOURCE price More Price(10)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 9002040 | Enniatin Complex ≥95% | 11113-62-5 | 10mg | $353 | 2024-03-01 | Buy |
| Cayman Chemical | 9002040 | Enniatin Complex ≥95% | 11113-62-5 | 50mg | $1057 | 2024-03-01 | Buy |
| TRC | E556028 | Enniatincomplex | 11113-62-5 | 5mg | $475 | 2021-12-16 | Buy |
| Usbiological | E3222-30 | Enniatin complex | 11113-62-5 | 10mg | $523 | 2021-12-16 | Buy |
| TRC | E556028 | Enniatincomplex | 11113-62-5 | 10mg | $660 | 2021-12-16 | Buy |
ENNIATIN FROM MICROBIAL SOURCE Chemical Properties,Uses,Production
Uses
Enniatin complex is a complex mixture of Fusarium produced depsipeptide ionophores.This compound can be used to control contamination in fermentation of gaseous substrates.
Uses
Enniatins are a complex of depsipeptides produced by several Fusarium species. Typically, the complex contains 4 major components: A, A1, B and B1 together with minor amounts of enniatins C, D, E and F. The enniatins act as ionophores. Recently their effects on acyl-CoA cholesterol transferase, as nematocides and the selectivity of their antitumour action have received more focus.
Biological Activity
enniatins, analogues of beauvericin, is a regular cyclic hexadepsipeptide isolated from fusarium species of fungis, also they have been isolated from other genera, such as verticillium and halosarpheia [1]. they have been involved in many biological activities, such as antiinsectan, antifungal, antibiotic and cytotoxic [1].
in vitro
fusafungine is a mixture of several enniatins with bacteriostatic activity against most micro-organisms responsible for infections and superinfections of the respiratory tract. fusafungine has been developed for treatment of upper respiratory tract infections by oral and/or nasal inhalation. fusafungine in low concentrations down-regulated the expression of intercellular adhesion molecule-1 (icam-1) by activated macrophages, inhibited the production of the proinflammatory cytokines il-1, tnfα and il-6 and inhibited the release of oxygen free radicals by inflammatory macrophages without altering their phagocytic activity. fusafungine also inhibited t-cell activation and proliferation, and the synthesis of ifn-γ by activated t cells [2]. exposure 8 h to enniatins at nanomolar concentrations significantly stimulated cell proliferation. at low micromolar concentrations, enniatins exihibited profound apoptosis-inducing effects against various human cancer cell types. in the fluorescence-activated cell sorting analysis, enniatins induced cell cycle arrest in the g0/g1 phase. in human cancer cells, elevated enn concentrations induced profound p53-dependent cytostatic and p53-independent cytotoxic activities [3]. enniatin easily incorporated into the cell membrane in which it formed cation-selective pores [4].
Purification Methods
It is a cyclic peptidic ester antibiotic which is recrystallised from EtOH/water but is deactivated in alkaline solution. [Ovchinnikov & Ivanov in The Proteins (Neurath and Hill eds) Academic Press, NY, Vol V pp. 365 and 516 1982, Tomeda et al. J Antibiot 45 1626 1992.]
References
[1] sy-cordero a a, pearce c j, oberlies n h. revisiting the enniatins: a review of their isolation, biosynthesis, structure determination and biological activities[j]. the journal of antibiotics, 2012, 65(11): 541-549.
[2] german-fattal m. fusafungine, an antimicrobial with anti-inflammatory properties in respiratory tract infections[j]. clinical drug investigation, 2001, 21(9): 653-670.
[3] dornetshuber r, heffeter p, kamyar m r, et al. enniatin exerts p53-dependent cytostatic and p53-independent cytotoxic activities against human cancer cells[j]. chemical research in toxicology, 2007, 20(3): 465-473.
[4] kamyar m, rawnduzi p, studenik c r, et al. investigation of the electrophysiological properties of enniatins[j]. archives of biochemistry and biophysics, 2004, 429(2): 215-223.
ENNIATIN FROM MICROBIAL SOURCE Preparation Products And Raw materials
Raw materials
Preparation Products
ENNIATIN FROM MICROBIAL SOURCE Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32957 | 60 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32165 | 58 |
| BOC Sciences | 16314854226; +16314854226 | inquiry@bocsci.com | United States | 19741 | 58 |
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38632 | 58 | |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52925 | 58 |
| Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 18892239720 | psaitong@jm-bio.com | China | 12306 | 58 |
| Lynnchem | 86-(0)29-85992781 17792393971 | info@lynnchem.com | China | 4587 | 58 |
| Novachemistry | 44-20819178-90 02081917890 | info@novachemistry.com | United Kingdom | 4381 | 58 |
| Shenzhen Polymeri Biochemical Technology Co., Ltd. | +86-400-002-6226 +86-13028896684; | sales@rrkchem.com | China | 57412 | 58 |
| BOC Sciences | -- | info@bocsci.com | USA | 0 | 65 |
| Supplier | Advantage |
|---|---|
| ATK CHEMICAL COMPANY LIMITED | 60 |
| TargetMol Chemicals Inc. | 58 |
| BOC Sciences | 58 |
| TargetMol Chemicals Inc. | 58 |
| Aladdin Scientific | 58 |
| Beijing Jin Ming Biotechnology Co., Ltd. | 58 |
| Lynnchem | 58 |
| Novachemistry | 58 |
| Shenzhen Polymeri Biochemical Technology Co., Ltd. | 58 |
| BOC Sciences | 65 |
View Lastest Price from ENNIATIN FROM MICROBIAL SOURCE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-10-24 | Enniatin complex
11113-62-5
|
US $2640.00-883.00 / mg | 10g | TargetMol Chemicals Inc. |
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- Enniatin complex
11113-62-5
- US $2640.00-883.00 / mg
- TargetMol Chemicals Inc.