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RS 102895

RS 102895 structure

CAS No.: 300815-41-2

Chemical Name:: RS 102895

Synonyms: 1'-(4-(trifluoromethyl)phenethyl)spiro[benzo[d][1,3]oxazine-4,4'-piperidin]-2(1H)-one;RS 102895 HYDROCHLORIDE;RS102895, 10 mM in DMSO;CC chemokine receptor,CCR,Inhibitor,RS102895,inhibit,RS-102895,RS 102895;1'-[2-[4-(trifluoromethyl)phenyl]ethyl]-spiro[4h-3,1-benzoxazine-4,4'-peperidin]-2(1h)-one;Spiro[4H-3,1-benzoxazine-4,4'-piperidin]-2(1H)-one, 1'-[2-[4-(trifluoromethyl)phenyl]ethyl]-;1'-(4-(TrifluoroMethyl)phenethyl)spiro[benzo[d][1,3]oxazine-4,4'-piperidin]-2(1H)-one hydrochloride;1'-[2-[4-(trifluoromethyl)phenyl]ethyl]spiro[1H-3,1-benzoxazine-4,4'-piperidine]-2-one,hydrochloride;1'-[2-[4-(TRIFLUOROMETHYL)PHENYL]ETHYL]-SPIRO[4H-3,1-BENZOXAZINE-4,4'-PIPERIDIN]-2(1H)-ONE HYDROCHLORIDE

CBNumber:: CB6504368

Molecular Formula:: C21H21F3N2O2

Molecular Weight:: 390.4

MDL Number:: MFCD05865241

MOL File:: 300815-41-2.mol

MSDS File:: SDS

Last updated:2025-04-17 18:22:24

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RS 102895 Properties

Boiling point	446.1±45.0 °C(Predicted)
Density	1.33±0.1 g/cm3 (20 ºC 760 Torr)
storage temp.	Desiccate at RT
solubility	DMSO: 18 mg/mL, clear, colorless
form	powder
pka	13.46±0.20(Predicted)
color	white
UNSPSC Code	12352202
NACRES	NA.32

SAFETY

Risk and Safety Statements

Safety Statements	22-24/25
WGK Germany	3

RS 102895 price More Price(7)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	R1903	RS 102895 hydrochloride ≥98% (HPLC), powder	300815-41-2	5mg	$241	2024-03-01	Buy
Tocris	2089	RS 102895 hydrochloride ≥99%(HPLC)	300815-41-2	10	$162	2021-12-16	Buy
Tocris	2089	RS 102895 hydrochloride ≥99%(HPLC)	300815-41-2	50	$682	2021-12-16	Buy
Usbiological	256510	RS 102895 hydrochloride	300815-41-2	10mg	$403	2021-12-16	Buy
American Custom Chemicals Corporation	API0008334	RS 102895 HYDROCHLORIDE 95.00%	300815-41-2	10MG	$345.45	2021-12-16	Buy

Product number	Packaging	Price	Buy
R1903	5mg	$241	Buy
2089	10	$162	Buy
2089	50	$682	Buy
256510	10mg	$403	Buy
API0008334	10MG	$345.45	Buy

RS 102895 Chemical Properties,Uses,Production

Uses

RS 102895 is a CCR2-selective chemokine receptor inhibitor.

Biological Activity

CCR2-selective chemokine receptor antagonist (IC 50 values are 0.36 and 17.8 μ M for inhibition of human recombinant CCR2b and CCR1 receptors respectively). Blocks MCP-1-stimulated calcium influx and chemotaxis with IC 50 values of 32 nM and 1.7 μ M respectively. Also inhibits α 1A , α 1D and 5-HT 1A receptors.

in vivo

RS102895 (3 g/L) causes progressive decrease in pain threshold in rats with bone cancer pain (BCP) at day 3-9 after surgery via intrathecal injection, but the pain threshold increases after 12 days. RS102895 also potently reverses the pattern of NR2B, nNOS, and SIGIRR expression in spinal cord^[3].

IC 50

CCR2: 360 nM (IC₅₀); CCR1: 17800 nM (IC₅₀); Human α_1a receptor: 130 nM (IC₅₀); Human α_1d receptor: 320 nM (IC₅₀); 5HT-1a receptor: 470 nM (IC₅₀)

RS 102895 Preparation Products And Raw materials

Raw materials

Preparation Products

RS 102895 Suppliers

Global( 109)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Shanghai UCHEM Inc.	+862156762820 +86-13564624040	sales@myuchem.com	China	7906	58
Hefei Hirisun Pharmatech Co., Ltd	+8615056975894	shawn@hirisunpharm.com	CHINA	9911	58
Henan Aochuang Chemical Co.,Ltd.	+86-0371-63689365 +8618638391208	sales@aochuangchem.com	China	9297	58
TargetMol Chemicals Inc.		support@targetmol.com	United States	38630	58
LEAPCHEM CO., LTD.	+86-852-30606658	market18@leapchem.com	China	43340	58
Jilin Chinese Academy of Sciences-yanshen Technology	+undefined18143011203	info@chemextension.com	China	42056	58
Aladdin Scientific		tp@aladdinsci.com	United States	57505	58
DAYANG CHEM (HANGZHOU) CO.,LTD	+8617705817739	info@dycnchem.com	China	53881	58
Amadis Chemical Company Limited	571-89925085	sales@amadischem.com	China	131957	58
Shanghai Boyle Chemical Co., Ltd.		sales@boylechem.com	China	2922	55

Supplier	Advantage
Shanghai UCHEM Inc.	58
Hefei Hirisun Pharmatech Co., Ltd	58
Henan Aochuang Chemical Co.,Ltd.	58
TargetMol Chemicals Inc.	58
LEAPCHEM CO., LTD.	58
Jilin Chinese Academy of Sciences-yanshen Technology	58
Aladdin Scientific	58
DAYANG CHEM (HANGZHOU) CO.,LTD	58
Amadis Chemical Company Limited	58
Shanghai Boyle Chemical Co., Ltd.	55

View Lastest Price from RS 102895 manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2025-04-04	RS 102895 300815-41-2	US $0.00-0.00 / kg	1kg	98%	1Ton	Henan Aochuang Chemical Co.,Ltd.
	2024-11-19	RS102895 300815-41-2	US $59.00-178.00 / mg		99.54%	10g	TargetMol Chemicals Inc.

RS 102895
300815-41-2
US $0.00-0.00 / kg
98%
Henan Aochuang Chemical Co.,Ltd.

RS102895
300815-41-2
US $59.00-178.00 / mg
99.54%
TargetMol Chemicals Inc.

300815-41-2(RS 102895)Related Search:

2,3-Dichloro-5-(trifluoromethyl)pyridine 2-fluoro-6-(trifluoroMethyl)benzene-1-sulfonyl chloride Inter-trifluoromethyl iodobenzene 4-(2-AMINOPHENYL)-1-PHENETHYLPIPERIDINE 4-(O-AMINO-PHENYL) PIPERIDINE HYDROCHLORIDE

RS 102895 1-Phenethyl-4-phenyl-4-piperidinol SPIRO[4H-3,1-BENZOXAZINE-4,4'-PIPERIDIN]-2(1H)-ONE

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1'-(4-(TrifluoroMethyl)phenethyl)spiro[benzo[d][1,3]oxazine-4,4'-piperidin]-2(1H)-one hydrochloride RS 102895 HYDROCHLORIDE 1'-[2-[4-(trifluoromethyl)phenyl]ethyl]-spiro[4h-3,1-benzoxazine-4,4'-peperidin]-2(1h)-one 1'-[2-[4-(TRIFLUOROMETHYL)PHENYL]ETHYL]-SPIRO[4H-3,1-BENZOXAZINE-4,4'-PIPERIDIN]-2(1H)-ONE HYDROCHLORIDE 1'-[2-[4-(trifluoromethyl)phenyl]ethyl]spiro[1H-3,1-benzoxazine-4,4'-piperidine]-2-one,hydrochloride Spiro[4H-3,1-benzoxazine-4,4'-piperidin]-2(1H)-one, 1'-[2-[4-(trifluoromethyl)phenyl]ethyl]- 1'-(4-(trifluoromethyl)phenethyl)spiro[benzo[d][1,3]oxazine-4,4'-piperidin]-2(1H)-one CC chemokine receptor,CCR,Inhibitor,RS102895,inhibit,RS-102895,RS 102895 RS102895, 10 mM in DMSO 300815-41-2 C21H21F3N2O2HCl RS 102895 CCR2-selective chemokine receptor antagonist. Cytokine signaling