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XPC-6444

XPC-6444 structure

CAS No.: 2230144-21-3

Chemical Name:: XPC-6444

Synonyms: XPC-6444;XPC 6444,XPC6444;https://pubmed.ncbi.nlm.nih.gov/34355886/;Benzenesulfonamide, 4-[[[2-[[(1,1-dimethylethyl)methylamino]methyl]-6-fluorophenyl]methyl]amino]-2,6-difluoro-N-4-thiazolyl-

CBNumber:: CB65821426

Molecular Formula:: C22H25F3N4O2S2

Molecular Weight:: 498.58

MDL Number:: MFCD32263401

MOL File:: 2230144-21-3.mol

Last updated:2023-05-21 10:59:17

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XPC-6444 Properties

Boiling point	574.8±60.0 °C(Predicted)
Density	1.384±0.06 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	DMSO : 125 mg/mL (250.71 mM; Need ultrasonic)
pka	5.73±0.10(Predicted)

XPC-6444 Chemical Properties,Uses,Production

Biological Activity

XPC-6444 is a highly potent, isoform-selective, and CNS-penetrant NaV1.6 inhibitor (IC50=41 nM for hNaV1.6). XPC-6444 also displays potent block of NaV1.2 (IC50=125 nM). XPC-6444 shows anticonvulsant activity[1]. XPC-6444 shows high selectivity over NaV1.1 and NaV1.5[1]. XPC-6444 exhibits good metabolic stability in human liver microsomes and hepatocytes, and low potential for MDR1 mediated efflux[1].

References

[1]. Focken T, et al. Identification of CNS-Penetrant Aryl Sulfonamides as Isoform-Selective NaV1.6 Inhibitors with Efficacy in Mouse Models of Epilepsy. J Med Chem. 2019 Oct 3.

XPC-6444 Preparation Products And Raw materials

Raw materials

Preparation Products

XPC-6444 Suppliers

Global( 7)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
ShangHai Caerulum Pharma Discovery Co., Ltd.	18149758185	sales-cpd@caerulumpharma.com	China	3423	58
Fan De(Beijing) Biotechnology Co., Ltd.	15911056312	liming@bio-fount.com	China	9730	58
DC Chemicals	021-58447131 13564518121	sales@dcchemicals.com	China	9414	58
TargetMol Chemicals Inc.	4008200310	marketing@tsbiochem.com	China	24018	58
Nantong QuanYi Biotechnology Co., Ltd	0513-66337626 18051384581	sales@chemhifuture.com	China	4191	58
RD International Technology Co., Limited	18024082417	market@ubiochem.com	China	9180	58

Supplier	Advantage
TargetMol Chemicals Inc.	58
ShangHai Caerulum Pharma Discovery Co., Ltd.	58
Fan De(Beijing) Biotechnology Co., Ltd.	58
DC Chemicals	58
TargetMol Chemicals Inc.	58
Nantong QuanYi Biotechnology Co., Ltd	58
RD International Technology Co., Limited	58

XPC-6444 https://pubmed.ncbi.nlm.nih.gov/34355886/ XPC 6444,XPC6444 Benzenesulfonamide, 4-[[[2-[[(1,1-dimethylethyl)methylamino]methyl]-6-fluorophenyl]methyl]amino]-2,6-difluoro-N-4-thiazolyl- 2230144-21-3