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XPC-6444
- CAS No.
- 2230144-21-3
- Chemical Name:
- XPC-6444
- Synonyms
- XPC-6444;XPC 6444,XPC6444;https://pubmed.ncbi.nlm.nih.gov/34355886/;Benzenesulfonamide, 4-[[[2-[[(1,1-dimethylethyl)methylamino]methyl]-6-fluorophenyl]methyl]amino]-2,6-difluoro-N-4-thiazolyl-
- CBNumber:
- CB65821426
- Molecular Formula:
- C22H25F3N4O2S2
- Molecular Weight:
- 498.58
- MDL Number:
- MFCD32263401
- MOL File:
- 2230144-21-3.mol
Last updated:2024-07-02 08:55:14
XPC-6444 Chemical Properties,Uses,Production
Biological Activity
XPC-6444 is a highly potent, isoform-selective, and CNS-penetrant NaV1.6 inhibitor (IC50=41 nM for hNaV1.6). XPC-6444 also displays potent block of NaV1.2 (IC50=125 nM). XPC-6444 shows anticonvulsant activity[1]. XPC-6444 shows high selectivity over NaV1.1 and NaV1.5[1]. XPC-6444 exhibits good metabolic stability in human liver microsomes and hepatocytes, and low potential for MDR1 mediated efflux[1].
References
[1]. Focken T, et al. Identification of CNS-Penetrant Aryl Sulfonamides as Isoform-Selective NaV1.6 Inhibitors with Efficacy in Mouse Models of Epilepsy. J Med Chem. 2019 Oct 3.
XPC-6444 Preparation Products And Raw materials
Raw materials
Preparation Products
XPC-6444 Suppliers
Global( 7)Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
ShangHai Caerulum Pharma Discovery Co., Ltd. | 18149758185 | sales-cpd@caerulumpharma.com | China | 3466 | 58 |
Fan De(Beijing) Biotechnology Co., Ltd. | 15911056312 | liming@bio-fount.com | China | 9730 | 58 |
DC Chemicals | 021-58447131 13564518121 | sales@dcchemicals.com | China | 9412 | 58 |
TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 23980 | 58 |
Nantong QuanYi Biotechnology Co., Ltd | 0513-66337626 18051384581 | sales@chemhifuture.com | China | 4659 | 58 |
RD International Technology Co., Limited | 18024082417 | market@ubiochem.com | China | 9268 | 58 |
XPC-6444
https://pubmed.ncbi.nlm.nih.gov/34355886/
XPC 6444,XPC6444
Benzenesulfonamide, 4-[[[2-[[(1,1-dimethylethyl)methylamino]methyl]-6-fluorophenyl]methyl]amino]-2,6-difluoro-N-4-thiazolyl-
2230144-21-3