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SR12343

SR12343 structure

CAS No.: 2055101-86-3

Chemical Name:: SR12343

Synonyms: SR12343;N-[2-(3-bromophenyl)ethyl]-2-[(5-chloro-2-pyridinyl)amino]-acetamide;Acetamide, N-[2-(3-bromophenyl)ethyl]-2-[(5-chloro-2-pyridinyl)amino]-

CBNumber:: CB65867455

Molecular Formula:: C15H15BrClN3O

Molecular Weight:: 368.66

MDL Number:

MOL File:: 2055101-86-3.mol

Last updated:2023-07-12 16:51:20

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SR12343 Properties

Boiling point	603.4±55.0 °C(Predicted)
Density	1.496±0.06 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	DMF: 30 mg/ml,DMSO: 30 mg/ml,Ethanol: 30 mg/ml
form	A crystalline solid
pka	14.86±0.46(Predicted)

SR12343 Chemical Properties,Uses,Production

Biological Activity

SR 12343 is a mimetic of the IκB kinase β (IKKβ) NEMO/IKKγ-binding domain (NBD) that inhibits the protein-protein interaction between the IKK complex subunits NF-κB essential modulator (NEMO/IKKγ) and IKKβ.1 It selectively disrupts the association of NEMO/IKKγ with IKKβ over TNF receptor-associated factor 2 (TRAF2), IκBα, and IKKα in co-immunoprecipitation assays using RAW 264.7 cells at concentrations ranging from 25 to 150 μM. SR 12343 inhibits TNF-α-induced NF-κB activation in a reporter assay. It reduces increased serum IL-6 levels in a mouse model of LPS-induced endotoxemia when administered at a dose of 10 mg/kg. SR 12343 (30 mg/kg) improves grip strength and reduces muscle fibrosis in the mdx mouse model of Duchenne muscular dystrophy.

References

1.Zhao, J., Zhang, L., Mu, X., et al.Development of novel NEMO-binding domain mimetics for inhibiting IKK/NF-kB activationPLoS Biol.16(6)e2004663(2018)

SR12343 Preparation Products And Raw materials

Raw materials

Preparation Products

SR12343 Suppliers

Global( 11)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6393	58
Shanghai EFE Biological Technology Co., Ltd.	021-65675885 18964387627	info@efebio.com	China	9708	58
Shanghai Chaolan Chemical Technology Center	QQ:65489617 15618227136	info@SuperLan-chem.com	China	9854	58
Jinan Jiuli Biotechnology Co. , Ltd.	2717893647 14768611851	486064515@qq.com	China	1703	58
ChemeGen 中国	18818260767	sales@chemegen.com	China	6975	58
InvivoChem	13549236410	sales@invivochem.cn	China	6749	58
Beijing Biocreative Technology Co., Ltd.	15522676233	3007606172@qq.com	China	1249	58
Nanjing Tengyi Biotechnology Co., Ltd	025-58851786 17714337195	sales@tybiochem.com	China	5448	58
YJ Pharma	0513-15251351988 15251351988	3686954964@qq.com	China	372	58
Nanjing Shizhou Biology Technology Co.,Ltd	025-85560043 15850508050	cindy.huang@synzest.com	China	12007	58

Supplier	Advantage
InvivoChem	58
Shanghai EFE Biological Technology Co., Ltd.	58
Shanghai Chaolan Chemical Technology Center	58
Jinan Jiuli Biotechnology Co. , Ltd.	58
ChemeGen 中国	58
InvivoChem	58
Beijing Biocreative Technology Co., Ltd.	58
Nanjing Tengyi Biotechnology Co., Ltd	58
YJ Pharma	58
Nanjing Shizhou Biology Technology Co.,Ltd	58

SR12343 Acetamide, N-[2-(3-bromophenyl)ethyl]-2-[(5-chloro-2-pyridinyl)amino]- N-[2-(3-bromophenyl)ethyl]-2-[(5-chloro-2-pyridinyl)amino]-acetamide 2055101-86-3 C15H15BrClN3O