ALMITRINE
- CAS No.
- 27469-53-0
- Chemical Name:
- ALMITRINE
- Synonyms
- S-2620;ALMITRINE;AlMitrine Mesylate;ALMITRINE USP/EP/BP;Almitrine dimethanesulfonic acid;2,4-Bis(allylamino)-6-[4-[bis(p-fluorophenyl)methyl]-1-piperazinyl]-s-triazine;1-[2,4-Bis(allylamino)-1,3,5-triazin-6-yl]-4-[bis(4-fluorophenyl)methyl]piperazine;6-[4-[Bis(4-fluorophenyl)methyl]-1-piperazinyl]-N,N'-di(2-propenyl)-1,3,5-triazine-2,4-diamine;1,3,5-Triazine-2,4-diamine, 6-[4-[bis(4-fluorophenyl)methyl]-1-piperazinyl]-N2,N4-di-2-propen-1-yl-
- CBNumber:
- CB6667472
- Molecular Formula:
- C26H29F2N7
- Molecular Weight:
- 477.55
- MDL Number:
- MFCD00868102
- MOL File:
- 27469-53-0.mol
- MSDS File:
- SDS
Melting point | 181° |
---|---|
Density | 1.2278 (estimate) |
form | Solid |
FDA UNII | 9A1222NBG4 |
ATC code | R07AB07 |
ALMITRINE price
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
American Custom Chemicals Corporation | API0009191 | ALMITRINE 95.00% | 27469-53-0 | 25MG | $225.75 | 2021-12-16 | Buy |
Medical Isotopes, Inc. | 18470 | Almitrine | 27469-53-0 | 5mg | $950 | 2021-12-16 | Buy |
Medical Isotopes, Inc. | 18470 | Almitrine | 27469-53-0 | 25mg | $1500 | 2021-12-16 | Buy |
AvaChem | 1592B | Almitrine | 27469-53-0 | 1g | $890 | 2021-12-16 | Buy |
AvaChem | 1592B | Almitrine | 27469-53-0 | 10mg | $49 | 2021-12-16 | Buy |
ALMITRINE Chemical Properties,Uses,Production
Originator
Armanor ,Les Laboratoires Servier
Uses
Respiratory stimulant.
Definition
ChEBI: A triamino-1,3,5-triazine compound having allylamino substituents at the 2- and 4-positions and a 4-(bis(p-fluorophenyl)methyl)-1-piperazinyl group at the 6-position.
Manufacturing Process
A solution of 4,6-bis(allylamino)-2-chloro-s-triazine, melting point 204°C (Kofler) and dihydrochloride of 1-p,p'-difluorobenzhydryl piperazine, melting point 178°-180°C (capillary) in anhydrous dimethylformamide are heated under reflux. On completion of this operation the solvent is removed under vacuum and the residue taken up in a mixture of chloroform and of water (1:1). The organic phase is separated, and repeatedly extracted with aqueous N-methanesulphonic acid and the aqueous acidic layers separated. The aforementioned acidic solutions are then combined and rendered alkaline (pH 10) with dilute aqueous sodium hydroxide, the base extracted with ether, the extract dried over anhydrous potassium carbonate, and filtered. The etheral filtrate, upon evaporation yields the 2,4-bis(allylamino)-6-(4-(bis(pfluorophenyl) methyl)-1-piperazinyl)-s-triazine, melting point 175°-180°C.
brand name
Vectarion (Oril S.A., France).
Therapeutic Function
Respiratory stimulant
World Health Organization (WHO)
Peripheral neuropathy has been reported in a few patients receiving almitrine for long periods. The indications for treatment have consequently been restricted in the Federal Republic of Germany. Some other countries have advised doctors to maintain patients under close supervision throughout treatment and to restrict dosage to two out of every three months.
Pharmacology
Almitrine, like doxapram, increases the rate and depth of respiration. In addition, it is believed that it redistributes pulmonary blood circulation, increasing it in alveoli, which leads to relatively better pulmonary ventilation. It has a more prolonged effect than doxapram.
Safety Profile
Poison by intraperitoneal andintravenous routes. When heated to decomposition itemits very toxic fumes of F?? and NOx.
Synthesis
Almitrine, 2,4-bis (allylamino)-6-[4-[bis-(p-fluorophenyl)methyl]-1-piperazinyl]-s-triazine (8.2.6), is synthesized by reacting 1-[bis-(p-fluorophenyl)methyl]piperazine with cyanuric chloride, which gives 2,4-dichloro-6-[4-[bis-(p-fluorophenyl) methyl]-1-piperazinyl]-s-trazine (8.2.5). Reacting this with allylamine gives almitrine (8.2.6) [19¨C22].
ALMITRINE Preparation Products And Raw materials
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29821 | 58 |
SIMAGCHEM CORP | +86-13806087780 | sale@simagchem.com | China | 17367 | 58 |
Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 23499 | 58 |
LUYUNJIA CHEMISTRY XIAMEN LIMITED | +86-592-5360779 +86-13055435203 | China | 5996 | 58 | |
Xiamen Eagle Chemical Limited Corporation | +86-5925023701 +86-18900207489 | yiyunchem@163.com | China | 6042 | 58 |
Shenzhen Sendi Biotechnology Co.Ltd. | 0755-23311925 18102838259 | Abel@chembj.com | CHINA | 3191 | 55 |
Beijing HuaMeiHuLiBiological Chemical | 010-56205725 | waley188@sohu.com | China | 12338 | 58 |
Shenzhen Simeiquan Biotechnology Co. Ltd | 18126413629 0755-23311925 2355327053 | abel@ycgmp.com | China | 5115 | 58 |
Shenzhen Sendi Biological Technology Co., Ltd. | 18124570582 TEL:0755-23574479 2355327139 | siliao02@yccreate.com | China | 6120 | 58 |
Taian Jiaye Biotechnology Co.Ltd | 13127280945 | 285424065@qq.com | China | 9980 | 55 |
View Lastest Price from ALMITRINE manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2021-07-28 | ALMITRINE USP/EP/BP
27469-53-0
|
US $1.10 / g | 1g | 99.9% | 100 Tons min | Dideu Industries Group Limited | ||
2020-02-01 | almitrine
27469-53-0
|
US $1.00 / KG | 1KG | Min98% HPLC | G/KG/TON | Career Henan Chemical Co |
- ALMITRINE USP/EP/BP
27469-53-0
- US $1.10 / g
- 99.9%
- Dideu Industries Group Limited
- almitrine
27469-53-0
- US $1.00 / KG
- Min98% HPLC
- Career Henan Chemical Co
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