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ChemicalBook >> CAS DataBase List >>2-Propynamide, 3-[5-[(4aR,8aS)-3,4,4a,5,8,8a-hexahydro-3-(1-methylethyl)-4-oxo-1-phthalazinyl]-2-methoxyphenyl]-N-(phenylmethyl)-, rel-

2-Propynamide, 3-[5-[(4aR,8aS)-3,4,4a,5,8,8a-hexahydro-3-(1-methylethyl)-4-oxo-1-phthalazinyl]-2-methoxyphenyl]-N-(phenylmethyl)-, rel-

2-Propynamide, 3-[5-[(4aR,8aS)-3,4,4a,5,8,8a-hexahydro-3-(1-methylethyl)-4-oxo-1-phthalazinyl]-2-methoxyphenyl]-N-(phenylmethyl)-, rel- Structure
2-Propynamide, 3-[5-[(4aR,8aS)-3,4,4a,5,8,8a-hexahydro-3-(1-methylethyl)-4-oxo-1-phthalazinyl]-2-methoxyphenyl]-N-(phenylmethyl)-, rel- structure
CAS No.
2376326-31-5
Chemical Name:
2-Propynamide, 3-[5-[(4aR,8aS)-3,4,4a,5,8,8a-hexahydro-3-(1-methylethyl)-4-oxo-1-phthalazinyl]-2-methoxyphenyl]-N-(phenylmethyl)-, rel-
Synonyms
NPD-1335;2-Propynamide, 3-[5-[(4aR,8aS)-3,4,4a,5,8,8a-hexahydro-3-(1-methylethyl)-4-oxo-1-phthalazinyl]-2-methoxyphenyl]-N-(phenylmethyl)-, rel-
CBNumber:
CB68181239
Molecular Formula:
C28H29N3O3
Molecular Weight:
455.55
MDL Number:
MOL File:
2376326-31-5.mol
Last updated:2024-07-02 08:55:14
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2-Propynamide, 3-[5-[(4aR,8aS)-3,4,4a,5,8,8a-hexahydro-3-(1-methylethyl)-4-oxo-1-phthalazinyl]-2-methoxyphenyl]-N-(phenylmethyl)-, rel- Properties

Density 1.17±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility Soluble in DMSO
pka 12.42±0.46(Predicted)
form Solid
color Off-white to light yellow

2-Propynamide, 3-[5-[(4aR,8aS)-3,4,4a,5,8,8a-hexahydro-3-(1-methylethyl)-4-oxo-1-phthalazinyl]-2-methoxyphenyl]-N-(phenylmethyl)-, rel- Chemical Properties,Uses,Production

Description

NPD1335 is a Trypanosoma brucei phosphodiesterase B1 (TbrPDEB1) inhibitor with submicromolar activities against T. brucei parasites. NPD1335 displays a greatly improved cytotoxicity profile. NPD1335 increases intracellular cAMP levels and results in the distortion of the cell cycle and cell death[1]. pKi: 6.9 (TbrPDEB1); pIC50: 6.2 (T. brucei) (NPD-1335)[1]

References

[1]. de Heuvel E, et al. Alkynamide phthalazinones as a new class of TbrPDEB1 inhibitors (Part 2). Bioorg Med Chem. 2019 Jul 5. pii: S0968-0896(19)30790-4.

2-Propynamide, 3-[5-[(4aR,8aS)-3,4,4a,5,8,8a-hexahydro-3-(1-methylethyl)-4-oxo-1-phthalazinyl]-2-methoxyphenyl]-N-(phenylmethyl)-, rel- Preparation Products And Raw materials

Raw materials

Preparation Products

2-Propynamide, 3-[5-[(4aR,8aS)-3,4,4a,5,8,8a-hexahydro-3-(1-methylethyl)-4-oxo-1-phthalazinyl]-2-methoxyphenyl]-N-(phenylmethyl)-, rel- Suppliers

Global( 3)Suppliers
Supplier Tel Email Country ProdList Advantage
Aladdin Scientific 		+1-+1(833)-552-7181 sales@aladdinsci.com United States 52927 58
RD International Technology Co., Limited 18024082417 market@ubiochem.com China 9268 58
TargetMol Chemicals Inc. 15002134094 marketing@targetmol.cn China 19698 58
Supplier Advantage
Aladdin Scientific 		58
RD International Technology Co., Limited 58
TargetMol Chemicals Inc. 58
2-Propynamide, 3-[5-[(4aR,8aS)-3,4,4a,5,8,8a-hexahydro-3-(1-methylethyl)-4-oxo-1-phthalazinyl]-2-methoxyphenyl]-N-(phenylmethyl)-, rel- NPD-1335 2376326-31-5