NNC 55-0396 dihydrochloride
- CAS No.
- 357400-13-6
- Chemical Name:
- NNC 55-0396 dihydrochloride
- Synonyms
- NNC 55-0396 2HCl;NNC 55-0396 DIHYDROCHLORIDE;NNC 55-0396 (Racemic Mixture);NNC 55-0396,inhibit,Ca2+ channels,Inhibitor,NNC 550396,NNC 55 0396,Calcium Channel,Ca channels;(1S,2S)-2-[2-[[3-(1H-BENZIMIDAZOL-2-YL)PROPYL]METHYLAMINO]ETHYL]-6-FLUORO-1,2,3,4-TETRAHYDRO-1-(1-METHYLETHYL)-2-NAPHTHALENYL CYCLOPROPANECARBOXYLATE DIHYDROCHLORIDE;(1S,2S)-2-(2-((3-(1H-benzo[d]imidazol-2-yl)propyl)(methyl)amino)ethyl)-6-fluoro-1-isopropyl-1,2,3,4-tetrahydronaphthalen-2-yl cyclopropanecarboxylate dihydrochloride;(1S,2S)-2-[2-[[3-(1H-BENZIMIDAZOL-2-YL)PROPYL]METHYLAMINO]ETHYL]-6-FLUORO-1,2,3,4-TETRAHYDRO-1-(1-METHYLETHYL)-2-NAPHTHALENYL CYCLOPROPANECARBOXYLATE DIHYDROCHLORIDE
- CBNumber:
- CB6824356
- Molecular Formula:
- C30H39ClFN3O2
- Molecular Weight:
- 528.11
- MDL Number:
- MFCD08703107
- MOL File:
- 357400-13-6.mol
- MSDS File:
- SDS
| Melting point | 174 - 179°C |
|---|---|
| storage temp. | Desiccate at RT |
| solubility | DMSO (Slightly), Water (Slightly) |
| form | Solid |
| color | White to Off-White |
| Water Solubility | Soluble to 25 mM in water |
| Stability | Hygroscopic |
| FDA UNII | 0A7CE46ERM |
NNC 55-0396 dihydrochloride price More Price(13)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 17216 | NNC 55-0396 ≥98% | 357400-13-6 | 1mg | $50 | 2024-03-01 | Buy |
| Cayman Chemical | 17216 | NNC 55-0396 ≥98% | 357400-13-6 | 5mg | $184 | 2024-03-01 | Buy |
| Cayman Chemical | 17216 | NNC 55-0396 ≥98% | 357400-13-6 | 10mg | $308 | 2024-03-01 | Buy |
| Cayman Chemical | 17216 | NNC 55-0396 | 357400-13-6 | 25mg | $669 | 2024-03-01 | Buy |
| Tocris | 2268 | NNC55-0396dihydrochloride ≥98%(HPLC) | 357400-13-6 | 10 | $298 | 2021-12-16 | Buy |
NNC 55-0396 dihydrochloride Chemical Properties,Uses,Production
Description
NNC 55-0396 is a selective inhibitor of T-type calcium channels that blocks Cav3.1 in stably expressing HEK293 cells (IC50 = 6.8 μM) with no discernible effect on high voltage-activated (L-type) channels in INS-1 cells up to a concentration of 100 μM. NNC 55-0396 suppresses tremor in two murine models, the GABAA α1-null (20 mg/kg) and harmaline-induced (12.5 mg/kg) tremor models, and was better tolerated than mibefradil . In arterial smooth muscle cells, NCC 55-0396 (IC50 = 80 nM) inhibits voltage-dependent K+ channels but does not affect their voltage sensitivity. NNC 55-0396 (1-5 μM) also suppresses angiogenesis in vitro by inhibiting hypoxia-inducible factor-1α activity, and it slows tumor growth of flank xenografts of U87MG cells in mice when administered at 20 mg/kg.
Uses
NNC 55-0396 is a calcium channel protein inhibitor.
Definition
ChEBI: NNC 55-0396 dihydrochloride is t-type calcium channel blocker It has a role as a calcium channel blocker.
Biological Activity
Highly selective T-type calcium channel blocker. Displays IC 50 values of 6.8 and > 100 μ M for inhibition of Cav3.1 T-type channels and HVA currents respectively in INS-1 cells.
in vitro
nnc 55-0396 showed no effect against high voltage calcium channels at 100 μm, but inhibited t-type channels in hek293 cells with a potency comparable to that of mibefradil (ic50 6.8 versus 10.1 μm) [1].
in vivo
nnc 55-0396 was better tolerated than mibefradil in the horizontalwire test. to assess for a potential interaction with harmaline in the inverted wire grid test, mice was given nnc 55-0396, followed by harmaline or vehicle. nnc 55-0396 ameliorated harmaline-induced test deficits. in the gabaa α1-null model, nnc 55-0396 at 12.5 mg/kg suppressed harmaline-induced tremor by half by 20–100 min, whereas mibefradil at the same dose did not significantly affect tremor. in contrast to mibefradil, nnc 55-0396 was well tolerated and suppresses tremor, and exerts less cytochrome p450 inhibition [1].
IC 50
6.8 μm for cav3.1 t-type channel
storage
Desiccate at RT
References
[1] quesada a,bui ph,homanics ge,hankinson o,handforth a. comparison of mibefradil and derivative nnc 55-0396 effects on behavior, cytochrome p450 activity, and tremor in mouse models of essential tremor. eur j pharmacol.2011 may 20;659(1):30-6.
NNC 55-0396 dihydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
NNC 55-0396 dihydrochloride Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 | sales@chemhifuture.com | China | 3136 | 58 |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43348 | 58 |
| Shanghai Acmec Biochemical Technology Co., Ltd. | +undefined18621343501 | product@acmec-e.com | China | 33350 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Wuhan Jingkang en Biomedical Technology Co., Ltd | +8613720134139 | orders@jknbiochem.com | China | 5225 | 58 |
| SHANGHAI KEAN TECHNOLOGY CO., LTD. | +8613817748580 | cooperation@kean-chem.com | China | 40067 | 58 |
| J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 96815 | 76 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 | 3bsc@sina.com | China | 15848 | 69 |