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NNC 55-0396 dihydrochloride

NNC 55-0396 dihydrochloride 구조식 이미지

카스 번호:: 357400-13-6

상품명:: NNC 55-0396 dihydrochloride

동의어(영문):: NNC 55-0396 2HCl;NNC 55-0396 DIHYDROCHLORIDE;NNC 55-0396 (Racemic Mixture);NNC 55-0396,inhibit,Ca2+ channels,Inhibitor,NNC 550396,NNC 55 0396,Calcium Channel,Ca channels;(1S,2S)-2-[2-[[3-(1H-BENZIMIDAZOL-2-YL)PROPYL]METHYLAMINO]ETHYL]-6-FLUORO-1,2,3,4-TETRAHYDRO-1-(1-METHYLETHYL)-2-NAPHTHALENYL CYCLOPROPANECARBOXYLATE DIHYDROCHLORIDE;(1S,2S)-2-(2-((3-(1H-benzo[d]imidazol-2-yl)propyl)(methyl)amino)ethyl)-6-fluoro-1-isopropyl-1,2,3,4-tetrahydronaphthalen-2-yl cyclopropanecarboxylate dihydrochloride;(1S,2S)-2-[2-[[3-(1H-BENZIMIDAZOL-2-YL)PROPYL]METHYLAMINO]ETHYL]-6-FLUORO-1,2,3,4-TETRAHYDRO-1-(1-METHYLETHYL)-2-NAPHTHALENYL CYCLOPROPANECARBOXYLATE DIHYDROCHLORIDE

CBNumber:: CB6824356

분자식:: C30H39ClFN3O2

포뮬러 무게:: 528.11

MOL 파일:: 357400-13-6.mol

속성

안전

용도

공급 업체 52

NNC 55-0396 dihydrochloride 속성

녹는점: 174 - 179°C

저장 조건: Desiccate at RT

용해도: DMSO(약간 용해됨), 물(약간 용해됨)

물리적 상태: 고체

물리적 상태: 단단한 모양

색상: 흰색에서 황백색까지

수용성: Soluble to 25 mM in water

안정성: 흡습성

안전

NNC 55-0396 dihydrochloride C화학적 특성, 용도, 생산

개요

NNC 55-0396 is a selective inhibitor of T-type calcium channels that blocks Ca_v3.1 in stably expressing HEK293 cells (IC₅₀ = 6.8 μM) with no discernible effect on high voltage-activated (L-type) channels in INS-1 cells up to a concentration of 100 μM. NNC 55-0396 suppresses tremor in two murine models, the GABA_A α₁-null (20 mg/kg) and harmaline-induced (12.5 mg/kg) tremor models, and was better tolerated than mibefradil . In arterial smooth muscle cells, NCC 55-0396 (IC₅₀ = 80 nM) inhibits voltage-dependent K⁺ channels but does not affect their voltage sensitivity. NNC 55-0396 (1-5 μM) also suppresses angiogenesis in vitro by inhibiting hypoxia-inducible factor-1α activity, and it slows tumor growth of flank xenografts of U87MG cells in mice when administered at 20 mg/kg.

용도

NNC 55-0396 is a calcium channel protein inhibitor.

생물학적 활성

Highly selective T-type calcium channel blocker. Displays IC 50 values of 6.8 and > 100 μ M for inhibition of Cav3.1 T-type channels and HVA currents respectively in INS-1 cells.

NNC 55-0396 dihydrochloride 준비 용품 및 원자재

원자재

준비 용품

NNC 55-0396 dihydrochloride 공급 업체

글로벌( 52)공급 업체

공급자	전화	이메일	국가	제품 수	이점
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6393	58
Nantong HI-FUTURE Biology Co., Ltd.	+undefined18051384581	sales@chemhifuture.com	China	3136	58
LEAPCHEM CO., LTD.	+86-852-30606658	market18@leapchem.com	China	43348	58
Shanghai Acmec Biochemical Technology Co., Ltd.	+undefined18621343501	product@acmec-e.com	China	33350	58
Aladdin Scientific	+1-+1(833)-552-7181	sales@aladdinsci.com	United States	57511	58
Wuhan Jingkang en Biomedical Technology Co., Ltd	+8613720134139	orders@jknbiochem.com	China	5225	58
J & K SCIENTIFIC LTD.	010-82848833 400-666-7788	jkinfo@jkchemical.com	China	96815	76
3B Pharmachem (Wuhan) International Co.,Ltd.	821-50328103-801 18930552037	3bsc@sina.com	China	15848	69
MedChemexpress LLC	021-58955995	sales@medchemexpress.cn	United States	4863	58