4-(4-Amino-3-fluorophenoxy)-N-(methyl-d3)-2-pyridinecarboxamide

4-(4-Amino-3-fluorophenoxy)-N-(methyl-d3)-2-pyridinecarboxamide structure

CAS No.: 1257864-28-0

Chemical Name:: 4-(4-Amino-3-fluorophenoxy)-N-(methyl-d3)-2-pyridinecarboxamide

Synonyms: 4-(4-Amino-3-fluorophenoxy)-N-(methyl-d3)-2-pyridinecarboxamide

CBNumber:: CB68394211

Molecular Formula:: C13H12FN3O2

Molecular Weight:: 261.26

MDL Number:

MOL File:: 1257864-28-0.mol

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4-(4-Amino-3-fluorophenoxy)-N-(methyl-d3)-2-pyridinecarboxamide Chemical Properties,Uses,Production

Uses

4-(4-Amino-3-fluorophenoxy)-N-(methyl-d3)-2-pyridinecarboxamide is an intermediate for the synthesis of Regorafenib-d3 (R143002), which is the isotope labelled analog of Regorafenib (R143000); a compound that inhibits PDGFR tyrosine kinase with IC50=83nM and is useful for the treatment of inflammation. Also an anti-proliferative agent.

4-(4-Amino-3-fluorophenoxy)-N-(methyl-d3)-2-pyridinecarboxamide Preparation Products And Raw materials

Raw materials

Preparation Products

4-(4-Amino-3-fluorophenoxy)-N-(methyl-d3)-2-pyridinecarboxamide 1257864-28-0