2,4,6-Collidine | 108-75-8

2,4,6-Collidine Properties

Melting point	-43 °C (lit.)
Boiling point	171-172 °C (lit.)
Density	0.917 g/mL at 25 °C (lit.)
vapor pressure	4 hPa (20 °C)
refractive index	n20/D 1.498(lit.)
Flash point	135 °F
storage temp.	Store below +30°C.
solubility	35g/l
pka	7.43(at 25℃)
form	Liquid
color	Clear colorless to yellow
Water Solubility	35 g/L (20 ºC)
Sensitive	Hygroscopic
Merck	14,9718
BRN	107283
Dielectric constant	1.9（20℃）
Stability	Stable. Combustible. Incompatible with strong oxidizing agents.
LogP	1.25 at 20℃
Indirect Additives used in Food Contact Substances	2,4,6-TRIMETHYLPYRIDINE
CAS DataBase Reference	108-75-8(CAS DataBase Reference)
FDA UNII	7IE4BK5J5V
NIST Chemistry Reference	Pyridine, 2,4,6-trimethyl-(108-75-8)
EPA Substance Registry System	2,4,6-Trimethylpyridine (108-75-8)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS02,GHS06

Signal word

Danger

Hazard statements

H226-H302+H332-H311-H315-H319-H335

Precautionary statements

P210-P280-P301+P312-P303+P361+P353-P304+P340+P312-P305+P351+P338

Hazard Codes

Xn

Risk Statements

10-20/21/22-36/37/38

Safety Statements

26-36/37-36

RIDADR

UN 1992 3/PG 3

WGK Germany

3

RTECS

UU0970000

TSCA

Yes

HazardClass

3

PackingGroup

III

HS Code

29333999

Toxicity

LD50 orally in Rabbit: 400 mg/kg

NFPA 704

	2
2		0

2,4,6-Collidine price More Price(33)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	8.22267	2,4,6-Trimethylpyridine for synthesis	108-75-8	50mL	$53	2024-03-01	Buy
Sigma-Aldrich	8.22267	2,4,6-Trimethylpyridine for synthesis	108-75-8	250ML	$110	2024-03-01	Buy
Sigma-Aldrich	8.22267	2,4,6-Trimethylpyridine for synthesis	108-75-8	1L	$429	2024-03-01	Buy
Sigma-Aldrich	142387	2,4,6-Trimethylpyridine ReagentPlus , 99%	108-75-8	5ml	$29.2	2024-03-01	Buy
Sigma-Aldrich	142387	2,4,6-Trimethylpyridine ReagentPlus , 99%	108-75-8	1l	$832	2024-03-01	Buy

Product number	Packaging	Price	Buy
8.22267	50mL	$53	Buy
8.22267	250ML	$110	Buy
8.22267	1L	$429	Buy
142387	5ml	$29.2	Buy
142387	1l	$832	Buy

2,4,6-Collidine Chemical Properties,Uses,Production

Chemical Properties

colourless liquid

Uses

2,4,6-Collidine is an reagent used for various synthetic preparations such as the synthesis of methylated pyridines by three-componet catalytic condensation of acetylene, acetone and ammonia.

Uses

2,4,6-Collidine is used as a tissue fixative for electron microscopy. It is useful in dehydrohalogenation reactions and acts as a solvent for the cleavage of hindered esters by anhydrous lithium iodide.

Definition

Methyl, ethyl, propyl, and trimethyl homologs of pyridine.

Synthesis Reference(s)

Journal of the American Chemical Society, 72, p. 4184, 1950 DOI: 10.1021/ja01165a097

General Description

2,4,6-Trimethylpyridine is a pyridine derivative. It has a pK of 7.4. The product can react with trifluoroiodomethane in cyclopentane solution to afford 1:1 complex. This complex was investigated by NMR (Nuclear Magnetic Resonance) spectroscopy. Collidine-buffered osmium tetroxide solutions have been prepared by adding osmium tetroxide solution to it. These solutions have been used as fixative for electron microscopic studies.
2,4,6-Trimethylpyridine can undergo oxidation with potassium permanganate to form 2,4,6-pyridinetricarboxylic acid.

Hazard

Toxic.

Flammability and Explosibility

Flammable

Purification Methods

Commercial samples may be grossly impure. Likely contaminants include 3,5-dimethylpyridine, 2,3,6-trimethylpyridine and water. Brown, Johnson and Podall [J Am Chem Soc 76 5556 1954] fractionally distilled 2,4,6-trimethylpyridine under reduced pressure through a 40cm Vigreux column (p 11) and added to 430mL of the distillate slowly, with cooling to 0o, 45g of BF3-diethyl etherate. The mixture was again distilled, and an equal volume of dry *benzene was added to the distillate. Dry HCl was passed into the solution, which was kept cold in an ice-bath, and the hydrochloride was filtered off. It was recrystallised from absolute EtOH (1.5mL/g) to m 286-287o[m 256o(sealed tube), also m 293-294o subliming slowly]. The free base was regenerated by treatment with aqueous NaOH, then extracted with *benzene, dried (MgSO4) and distilled under reduced pressure. Sisler et al. [J Am Chem Soc 75 446 1953] precipitated trimethylpyridine as its phosphate from a solution of the base in MeOH by adding 85% H3PO4, shaking and cooling. The free base was regenerated as above. Garrett and Smythe [J Chem Soc 763 1903] purified the trimethylpyridine via the HgCl2 complex. It is more soluble in cold than hot H2O [the solubility is 20.8% at 6o, 3.5% at 20o, 1.8% at 100o]. Alternatively, purify it by dissolving it in CHCl3, adding solid K2CO3 and Drierite, filtering and fractionally distilling through an 8in helix-packed column. The sulfate has m 205o, and the picrate (from hot H2O) has m 155-156o. [Frank & Meikle J Am Chem Soc 72 4184 1950, Beilstein 20 H 250, 20 I 87, 20 II 164, 20 III/IV 2810, 20/6 V 93.]

2,4,6-Collidine synthesis

Synthesis of 2,4,6-Collidine from 2,4,6-trimethylpyridine 1-oxide

2,4,6-Collidine Preparation Products And Raw materials

Raw materials

Acetone Zinc chloride Urea Benzene Phosphorus pentoxide

Sulfuric acid Ammonia 2,3,6-TRIMETHYLPYRIDINE 1,2,4-Trimethylbenzene Mesitylene

Acetonitrile Propyne

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Preparation Products

4,6-DIMETHYL-PYRIDINE-2-CARBOXYLIC ACID 2-Cyclopenten-1-one Estrone 2.4.6-TRIMETHYL-3-NITROPYRIDINE

2,4,6-Collidine Suppliers

Global( 510)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Nanjing Sinoda Biological Technology Co., Ltd	+8613401983379	sales@njmcn.cn	CHINA	74	58
Nanjing Yushan Wanfang Biotechnology Co., Ltd.	+86-025-84918180 +86-18014482516	3552541679@qq.com	China	997	58
Firsky International Trade (Wuhan) Co., Ltd	+8615387054039	admin@firsky-cn.com	China	427	58
Hebei Saisier Technology Co., LTD	+86-18400010335 +86-18034520335	admin@hbsaisier.cn	China	1015	58
Hebei Longbang Technology Co., LTD	+86-18633929156 +86-18633929156	admin@hblongbang.com	China	941	58
HebeiShuoshengImportandExportco.,Ltd	+86-18532138899 +86-18532138899	L18532138899@163.com	China	939	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29791	60
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21634	55
Nanjing ChemLin Chemical Industry Co., Ltd.	025-83697070	product@chemlin.com.cn	CHINA	3009	60
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32957	60

Supplier	Advantage
Nanjing Sinoda Biological Technology Co., Ltd	58
Nanjing Yushan Wanfang Biotechnology Co., Ltd.	58
Firsky International Trade (Wuhan) Co., Ltd	58
Hebei Saisier Technology Co., LTD	58
Hebei Longbang Technology Co., LTD	58
HebeiShuoshengImportandExportco.,Ltd	58
Capot Chemical Co.,Ltd.	60
Henan Tianfu Chemical Co.,Ltd.	55
Nanjing ChemLin Chemical Industry Co., Ltd.	60
ATK CHEMICAL COMPANY LIMITED	60

View Lastest Price from 2,4,6-Collidine manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-11-22	2,4,6-Collidine 108-75-8	US $6.00 / kg	1kg	99%	2000KG/Month	HebeiShuoshengImportandExportco.,Ltd
2024-11-21	2,4,6-Collidine 108-75-8	US $0.00-0.00 / Kg/Drum	1KG	99%min	10 TONS/Month	WUHAN FORTUNA CHEMICAL CO., LTD
2024-11-20	2,4,6-Collidine 108-75-8	US $6.00 / KG	1KG	99%	20TONS	Hebei Longbang Technology Co., Ltd

2,4,6-Collidine
108-75-8
US $6.00 / kg
99%
HebeiShuoshengImportandExportco.,Ltd

2,4,6-Collidine
108-75-8
US $0.00-0.00 / Kg/Drum
99%min
WUHAN FORTUNA CHEMICAL CO., LTD

2,4,6-Collidine
108-75-8
US $6.00 / KG
99%
Hebei Longbang Technology Co., Ltd

2,4,6-Collidine Spectrum

2,4,6-Collidine(108-75-8)MS 2,4,6-Collidine(108-75-8)¹HNMR 2,4,6-Collidine(108-75-8)¹³CNMR 2,4,6-Collidine(108-75-8)IR1 2,4,6-Collidine(108-75-8)IR2

108-75-8(2,4,6-Collidine)Related Search:

Pyridine sulfur trioxide 4-Methylpyridine Azamethiphos 2-Chloro-5-chloromethylpyridine 2,6-Lutidine

trimethylpyridine,MIX-COLLIDINE,collidine(combustibleliquid,n.o.s. Pyrroloquinoline quinone 2,3,5-COLLIDINE,2,3,5-COLLIDINE 2,3,5-TRIMETHYLPYRIDINE,2,3,5-Collidine, 99+%,2,3,5-COLLIDINE 2,3,5-TRIMETHYLPYRIDINE,2,3,5-TRIMETHYLPYRIDINE 2.4.6-TRIMETHYL-3-NITROPYRIDINE HYDROGEN FLUORIDE 2,4,6-COLLIDINE COMPLEX

1-FLUORO-2,4,6-TRIMETHYLPYRIDINIUM TRIFLATE Streptonigrin 2,6-Di-tert-butyl-4-methylpyridine 2,4,6-TRI-TERT-BUTYLPYRIDINE 2,6-DIPHENYL-4-(2,4,6-TRIPHENYL-1-PYRIDINIO)PHENOLATE

2,4,6-TRIMETHYLPYRIDINIUM P-TOLUENESULFONATE 2,4,6-TRIPHENYLPYRIDINE 3-Acetyl-2,4,6-trimethylpyridine

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2,4,6-trimethyl-pyridin a,g,a'-Collidine alpha,gamma,alpha’-collidine alpha,gamma,alpha'-Collidine Pyridine,2,4,6-trimethyl- 2 Minus 2-3 Methyl pyridine 2,4,6-Trimethylpyridine puriss. p.a., >=99.0% (GC) 2,4,6-Trimethylpyridine ReagentPlus(R), 99% 2,4,6-Trimethylpyridine Vetec(TM) reagent grade, 98% TMP 2,4,6-Collidine sym-Collidine s-Collidine SYM COLLIDINE 246CO 2,4,6-COLLIDINE GAMMA-COLLIDINE 2,4,6-COLLIDINE, REAGENTPLUS, 99% #nsym.-Collidine 2,4,6-Collidine99% 2,4,6-Collidine 99% Trimethylpyridine, 2,4,6- 2,4,6-COLLIDIN pure 2,4,6-Collidine, sym-Collidine 1H-Tetrazole, 5-phenyl-, barium salt Barium 5-phenyl-2,3,4-triaza-1-azanidacyclopenta-2,4-diene 2,4,6-Trimethylpyridine ,99% 2,4,6-Collidine,99%,electron microscopy grade 2,4,6-Collidine,75%,tech. 2,4,6-Trimethylpyridine,2,4,6-Collidine, sym-Collidine 2,4,6-Trimethylpyrid 2,4,6-Collidine, Reagent 2,4,6-Collidine, 99% 100ML 2,4,6-Collidine, 99% 500ML 2,4,6-Collidine, electron microscopy grade, 99% 2,4,6-Collidine, tech., 75% 2,6 -Dimethylpyridine (2,4,6-dimethylpyridine) 2,4,6-TRIMETHYLPYRIDINE(2,4,6-COLLIDINE) 2,4,6-COLLIDINE: 97.5% 2,4,6-COLLIDINE 2,4,6-TRIMETHYLPYRIDINE 2,4,6-Collidine 98+ % 2,4,6-Trimethylpyridine, 98.5% 2,4,6-CoL 2,4,6-Trimethylpyridine, 98.5%, for synthesis 2,4,6-Trimethylpyridine > 2,4,6-TRIMETHYLPYRIDINE FOR SYNTHESIS 2 minus 2 - butyl can force 2,4,6-Trimethylpyridinev Aqualine Electrolyte AD-G, for Karl Fischer analysis 2,4,6-Collidine pure, 98% 2,4,6-Kollidin g-Collidine S-COLLIDINE 2,4,6-TRIMETHYLPYRIDINE 246BD 108-75-8 Puriss p.a. General Use Analytical Reagents Analytical Chromatography Product Catalog Heterocyclic Compounds