ChemicalBook >> CAS DataBase List >>1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-5-[4-(4-piperidinyl)-1-piperazinyl]-

1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-5-[4-(4-piperidinyl)-1-piperazinyl]-

1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-5-[4-(4-piperidinyl)-1-piperazinyl]- structure

CAS No.: 2229716-11-2

Chemical Name:: 1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-5-[4-(4-piperidinyl)-1-piperazinyl]-

Synonyms: 2-(2,6-dioxopiperidin-3-yl)-5-(4-(piperidin-4-yl)piperazin-1-yl)isoindoline-1,3-dione;1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-5-[4-(4-piperidinyl)-1-piperazinyl]-

CBNumber:: CB69018738

Molecular Formula:: C22H27N5O4

Molecular Weight:: 425.48

MDL Number:

MOL File:: 2229716-11-2.mol

Last updated:2023-02-23 14:24:07

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1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-5-[4-(4-piperidinyl)-1-piperazinyl]- Properties

Boiling point	686.0±55.0 °C(Predicted)
Density	1.367±0.06 g/cm3(Predicted)
pka	10.83±0.40(Predicted)

1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-5-[4-(4-piperidinyl)-1-piperazinyl]- Chemical Properties,Uses,Production

Biological Activity

Thalidomide-Piperazine-Piperidine is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].

References

[1]. Sato T, et al. Cereblon-Based Small-Molecule Compounds to Control Neural Stem Cell Proliferation in Regenerative Medicine. Front Cell Dev Biol. 2021;9:629326. Published 2021 Mar 11. [2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-1008.

1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-5-[4-(4-piperidinyl)-1-piperazinyl]- Preparation Products And Raw materials

Raw materials

Preparation Products

1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-5-[4-(4-piperidinyl)-1-piperazinyl]- Suppliers

Global( 5)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Shanxi Tihondan Pharmaceutical Technology Co., Ltd	+8618235132063	sales@tihondan.com	China	3725	58
SuZhou Medinoah Co.,LTD.	0512-0512-69561983 13914027025	he_qf@medinoah.com	China	3449	58
Jilin Province Woda Biotechnology Co., Ltd.	13504435624	1927928688@qq.com	China	1374	58
Wuhan Yuxiang Medical Technology Co., Ltd.	13971275651	sales@whyxpharma.com	China	4274	58
Abosyn	0512-69561983 13914027025	he_qf@medinoah.com	China	3001	58

Supplier	Advantage
Shanxi Tihondan Pharmaceutical Technology Co., Ltd	58
SuZhou Medinoah Co.,LTD.	58
Jilin Province Woda Biotechnology Co., Ltd.	58
Wuhan Yuxiang Medical Technology Co., Ltd.	58
Abosyn	58

1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-5-[4-(4-piperidinyl)-1-piperazinyl]- 2-(2,6-dioxopiperidin-3-yl)-5-(4-(piperidin-4-yl)piperazin-1-yl)isoindoline-1,3-dione 2229716-11-2