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ChemicalBook >> CAS DataBase List >>3-Pyridinecarboxamide, N-cyclobutyl-6-[2-(3-fluorophenyl)ethynyl]-

3-Pyridinecarboxamide, N-cyclobutyl-6-[2-(3-fluorophenyl)ethynyl]-

3-Pyridinecarboxamide, N-cyclobutyl-6-[2-(3-fluorophenyl)ethynyl]- Structure
3-Pyridinecarboxamide, N-cyclobutyl-6-[2-(3-fluorophenyl)ethynyl]- structure
CAS No.
1310012-12-4
Chemical Name:
3-Pyridinecarboxamide, N-cyclobutyl-6-[2-(3-fluorophenyl)ethynyl]-
Synonyms
3-Pyridinecarboxamide, N-cyclobutyl-6-[2-(3-fluorophenyl)ethynyl]-;VU0360172,CD1 mice,Metabotropic glutamate receptors,Polyphosphoinositide,Inhibitor,PI hydrolysis,mGluR,inhibit
CBNumber:
CB69020856
Molecular Formula:
C18H15FN2O
Molecular Weight:
294.32
MDL Number:
MOL File:
1310012-12-4.mol
Last updated:2024-07-02 08:55:14
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3-Pyridinecarboxamide, N-cyclobutyl-6-[2-(3-fluorophenyl)ethynyl]- Properties

Boiling point 506.8±45.0 °C(Predicted)
Density 1.27±0.1 g/cm3(Predicted)
storage temp. 4°C, protect from light
solubility DMSO : 83.33 mg/mL (283.13 mM; Need ultrasonic)
pka 13.78±0.20(Predicted)
form Solid
color Light yellow to brown

3-Pyridinecarboxamide, N-cyclobutyl-6-[2-(3-fluorophenyl)ethynyl]- Chemical Properties,Uses,Production

Biological Activity

VU0360172 is a potent and selective mGlu5 receptor positive allosteric modulator with an EC50 value of 16 nM and a Ki of 195 nM, respectively. VU0360172 stimulates polyphosphoinositide (PI) hydrolysis in vivo, which is abrogated in mGlu5 receptors gene deleted mice[1].

References

[1]. Zuena AR, et al. In Vivo Non-radioactive Assessment of mGlu5 Receptor-Activated Polyphosphoinositide Hydrolysis in Response to Systemic Administration of a Positive Allosteric Modulator. Front Pharmacol. 2018 Jul 31;9:804.

3-Pyridinecarboxamide, N-cyclobutyl-6-[2-(3-fluorophenyl)ethynyl]- Preparation Products And Raw materials

Raw materials

Preparation Products

3-Pyridinecarboxamide, N-cyclobutyl-6-[2-(3-fluorophenyl)ethynyl]- Suppliers

Global( 7)Suppliers
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TargetMol Chemicals Inc. 		support@targetmol.com United States 38463 58
Shanghai Chaolan Chemical Technology Center QQ:65489617 15618227136 info@SuperLan-chem.com China 7034 58
DC Chemicals 021-58447131 13564518121 sales@dcchemicals.com China 9410 58
Jingmo (Xiamen) Biotechnology Co., Ltd 13621943973 sales@jamxmpharmatech.com China 1106 58
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Nanjing Shizhou Biology Technology Co.,Ltd 025-85560043 15850508050 cindy.huang@synzest.com China 12005 58
Supplier Advantage
TargetMol Chemicals Inc. 		58
Shanghai Chaolan Chemical Technology Center 58
DC Chemicals 58
Jingmo (Xiamen) Biotechnology Co., Ltd 58
TargetMol Chemicals Inc. 58
Shanghai Yifei Biotechnology Co. , Ltd. 58
Nanjing Shizhou Biology Technology Co.,Ltd 58
3-Pyridinecarboxamide, N-cyclobutyl-6-[2-(3-fluorophenyl)ethynyl]- VU0360172,CD1 mice,Metabotropic glutamate receptors,Polyphosphoinositide,Inhibitor,PI hydrolysis,mGluR,inhibit 1310012-12-4