Pramipexole dihydrochloride monohydrate
- CAS No.
- 191217-81-9
- Chemical Name:
- Pramipexole dihydrochloride monohydrate
- Synonyms
- Pramipexole dihydrochloride monohydrate;Mirapex;Pramipexole for system suitability CRS;Pra-API;Pramipexole;Unii-3D867np06j;Pramipexole powder;PPX dihydrochloride;Pramipexole HCl hydrate;Pramipexole monohydrate
- CBNumber:
- CB6969615
- Molecular Formula:
- C10H20ClN3OS
- Molecular Weight:
- 265.8
- MDL Number:
- MFCD00876894
- MOL File:
- 191217-81-9.mol
| Melting point | 290 °C(dec.) |
|---|---|
| storage temp. | 2-8°C |
| solubility | Freely soluble in water, soluble in methanol, sparingly soluble or slightly soluble in ethanol (96 per cent), practically insoluble in methylene chloride. |
| form | Solid |
| color | White to Almost white |
| Merck | 14,7705 |
| BCS Class | 1 |
| InChI | InChI=1/C10H17N3S.ClH.H2O/c1-2-5-12-7-3-4-8-9(6-7)14-10(11)13-8;;/h7,12H,2-6H2,1H3,(H2,11,13);1H;1H2/t7-;;/s3 |
| InChIKey | ZTZQAWQFTIVKMU-DCFBZVEJNA-N |
| SMILES | NC1SC2C[C@@H](NCCC)CCC=2N=1.Cl.O |&1:5,r| |
| EWG's Food Scores | 1 |
| FDA UNII | 3D867NP06J |
| NCI Drug Dictionary | Mirapex |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H336 |
| Precautionary statements | P261-P264-P270-P271-P301+P312-P304+P340+P312 |
| WGK Germany | 3 |
| RTECS | DL3375000 |
| HS Code | 2934200000 |
Pramipexole dihydrochloride monohydrate price More Price(22)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | Y0001187 | Pramipexole for system suitability European Pharmacopoeia (EP) Reference Standard | 191217-81-9 | y0001187 | $150 | 2024-03-01 | Buy |
| Sigma-Aldrich | PHR1598 | Pramipexole dihydrochloride | 191217-81-9 | 500mg | $105 | 2024-03-01 | Buy |
| TCI Chemical | P2073 | Pramipexole Dihydrochloride Monohydrate >98.0%(HPLC)(N) | 191217-81-9 | 100mg | $28 | 2024-03-01 | Buy |
| TCI Chemical | P2073 | Pramipexole Dihydrochloride Monohydrate >98.0%(HPLC)(N) | 191217-81-9 | 1g | $152 | 2024-03-01 | Buy |
| Sigma-Aldrich | Y0001266 | Pramipexole dihydrochloride monohydrate European Pharmacopoeia (EP) Reference Standard | 191217-81-9 | y0001266 | $150 | 2024-03-01 | Buy |
Pramipexole dihydrochloride monohydrate Chemical Properties,Uses,Production
Description
Pramipexole dihydrochloride monohydrate is an activator of D2DR, D3DR and D4DR. Pramipexole has been found to have neuroprotective effects independent of its dopamine receptor agonism. It reduces mitochondrial reactive oxygen species (ROS) production and inhibits the activation of apoptotic pathways.
Chemical Properties
White or almost white, crystalline powder.
Uses
Pramipexole is a drug used to treat the symptoms of Parkinson's Disease (PD) and a antidepressant. It is a non-ergot dopamine agonist drug that is efficacious in treating various Parkinson's symptoms such as tremor, rigidity, and bradykinesia (slow movement)
Definition
ChEBI: A hydrate that is the monohydrate of the dihydrochloride salt of pramiprexole.
brand name
Mirapex (Boehringer Ingelheim).
General Description
Pramipexole Dihydrochloride is a non-ergot dopamine agonist widely used for the treatment of early and advanced Parkinson′s disease (PD). It is also used to treat restless legs syndrome.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Clinical Use
Parkinson’s disease
Symptomatic treatment of restless legs
Side effects
Dizziness, lightheadedness, or fainting, especially when standing up suddenly from a sitting/lying position.
drowsiness.
nausea.
seeing, hearing, or feeling things that are not there.
trouble sleeping.
twitching, twisting, or other unusual body movements.
unusual tiredness or weakness.
Drug interactions
Potentially hazardous interactions with other drugs
Avoid concomitant use with antipsychotics.
Metabolism
Pramipexole undergoes <10% metabolism to inactive
metabolites.
More than 90% of a dose is excreted via renal tubular
secretion unchanged into the urine.
Pramipexole dihydrochloride monohydrate Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Weibang Biotechnology Co., Ltd | +8615531157085 | abby@weibangbio.com | China | 8810 | 58 |
| Hebei Mojin Biotechnology Co., Ltd | +86 13288715578 +8613288715578 | sales@hbmojin.com | China | 12834 | 58 |
| Hebei Chuanghai Biotechnology Co,.LTD | +86-13131129325 | sales1@chuanghaibio.com | China | 5889 | 58 |
| Henan Bao Enluo International TradeCo.，LTD | +86-17331933971 +86-17331933971 | deasea125996@gmail.com | China | 2472 | 58 |
| Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +8617865335152 | Mandy@hangyubiotech.com | China | 10986 | 58 |
| zhuzhou dingcheng meihei comestic co.,ltd | +8618873369619 | dingchengbusiness8@163.com | China | 260 | 58 |
| Shanghai Getian Industrial Co., LTD | +86-15373193816 +86-15373193816 | mike@ge-tian.com | China | 269 | 58 |
| HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD | +8615350851019 | admin@86-ss.com | China | 1001 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21634 | 55 |
| Hangzhou FandaChem Co.,Ltd. | +8615858145714 | FandaChem@Gmail.com | China | 9087 | 55 |
View Lastest Price from Pramipexole dihydrochloride monohydrate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-12-23 | Pramipexole hydrochloride
191217-81-9
|
US $0.00-0.00 / g | 10g | 99% HPLC | 1000kg | HangZhou RunYan Pharma Technology Co.,LTD. | |
 |
2024-12-23 | Pramipexole dihydrochloride monohydrate
191217-81-9
|
US $1000.00-400.00 / kg | 1kg | 99% | 5000 | HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD | |
 |
2024-12-13 | Pramipexole
191217-81-9
|
US $0.00 / Kg/Bag | 10g | 99%-101%;BP | 100KGS | WUHAN FORTUNA CHEMICAL CO., LTD |
-
- Pramipexole hydrochloride
191217-81-9
- US $0.00-0.00 / g
- 99% HPLC
- HangZhou RunYan Pharma Technology Co.,LTD.
-
- Pramipexole dihydrochloride monohydrate
191217-81-9
- US $1000.00-400.00 / kg
- 99%
- HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
-
- Pramipexole
191217-81-9
- US $0.00 / Kg/Bag
- 99%-101%;BP
- WUHAN FORTUNA CHEMICAL CO., LTD