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Epothilone A

Epothilone A structure

CAS No.: 152044-53-6

Chemical Name:: Epothilone A

Synonyms: CS-555;CS-1899;Epothile;Ebomycin A;Epothilon A;Epothilone-S;EPOTHILONE A;(-)-EPOTHILONE A;epothile|||Epo A;Epothilone A (Epo A)

CBNumber:: CB6972280

Molecular Formula:: C26H39NO6S

Molecular Weight:: 493.66

MDL Number:: MFCD26960884

MOL File:: 152044-53-6.mol

MSDS File:: SDS

Last updated:2024-11-19 23:02:33

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Epothilone A Properties

Melting point	95℃
alpha	D21 -47.1° (c = 1.0 in methanol)
Boiling point	683.3±55.0 °C(Predicted)
Density	1.143
storage temp.	-20°C
solubility	Chloroform (Slightly), Ethyl Acetate (Slightly)
pka	13.57±0.70(Predicted)
form	solid
color	White to Off-White
Stability	Stable under recommended storage conditions., Stable Under Recommended Storage C
InChIKey	HESCAJZNRMSMJG-KKQRBIROSA-N
SMILES	[C@]12([H])[C@]([H])(O1)CCC[C@H](C)[C@H](O)[C@@H](C)C(=O)C(C)(C)[C@@H](O)CC(=O)O[C@H](/C(/C)=C/C1=CSC(C)=N1)C2
FDA UNII	51E07YBX96

SAFETY

Risk and Safety Statements

WGK Germany	3

Epothilone A price More Price(29)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	E3656	(?)-Epothilone A fromSorangiumcellulosum,>95%(HPLC),solid	152044-53-6	10μg	$102	2024-03-01	Buy
Cayman Chemical	16482	Epothilone A ≥95%	152044-53-6	1mg	$44	2024-03-01	Buy
Cayman Chemical	16482	Epothilone A ≥95%	152044-53-6	5mg	$118	2024-03-01	Buy
Cayman Chemical	16482	Epothilone A ≥95%	152044-53-6	10mg	$214	2024-03-01	Buy
Usbiological	E3428-74	Epothilone A	152044-53-6	100ug	$513	2021-12-16	Buy

Product number	Packaging	Price	Buy
E3656	10μg	$102	Buy
16482	1mg	$44	Buy
16482	5mg	$118	Buy
16482	10mg	$214	Buy
E3428-74	100ug	$513	Buy

Epothilone A Chemical Properties,Uses,Production

Uses

The epothilones are a novel class of antineoplastic agents possessing antitubulin activity. Epothilone A, B isolated from Sorangium cellulosum was associated with cell cycle arrest at G2/M transition and apoptosis that was resisted with overexpression of β-tubulin and P-glycoprotein in human bladder carcinoma cell.

Uses

Epothilone A is a microtubule inhibitor isolated from the myxobacteria, Sorangium cellulosum. Epothilone A acts by stabilising microtubule formation at the taxol binding site, and causes cell cycle arrest at the G2/M transition, leading to cytotoxicity. Epothilone A has been investigated in clinical trials as an antitumour agent.

Definition

ChEBI: An epithilone that is epothilone C in which the double bond in the macrocyclic lactone ring has been oxidised to the corresponding epoxide (the 13R,14S diastereoisomer).

Biological Activity

epothilone a (epo a) is a naturally occurring microtubule-stabilizing macrolide that was first isolated from the myxobacterium sorangium cellulosum. the ic50 value of epothilone a in hct-116 cell line is 4.4 nm [1].it has been found that the skov-3 human ovarian cancer cells were susceptible to epothilone a with ic50 value of 20.4 ± 1.4 nm [2]. the antiproliferative capacity of epothilone a in skov-3 cell line (measured as ic50 after 72 h continuous treatment) was six times greater than that of ptx’s. besides, epothilone a induced time coursedependent apoptosis and necrosis [2].

target

MDR CCRF-CEM/VBL100 cells

References

[1] regueiro-ren a1, borzilleri rm, zheng x, kim sh, johnson ja, fairchild cr, lee fy, long bh, vite gd. synthesis and biological activity of novel epothilone aziridines. org lett. 2001 aug 23;3(17):2693-6.
[2] rogalska a1, marczak a, gajek a, szwed m, śliwińska a, drzewoski j, jóźwiak z. induction of apoptosis in human ovarian cancer cells by new anticancer compounds, epothilone a and b. toxicol in vitro. 2013 feb;27(1):239-49.

Epothilone A Preparation Products And Raw materials

Raw materials

Preparation Products

Epothilone A Suppliers

Global( 134)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Accendatech Co., Ltd.	+8613132578992	yunhao.liu@accendatech.com	China	251	58
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29880	58
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28172	58
Standardpharm Co. Ltd.	86-714-3992388	overseasales1@yongstandards.com	United States	14332	58
Chongqing Chemdad Co., Ltd	+86-023-6139-8061 +86-86-13650506873	sales@chemdad.com	China	39894	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49374	58
SIMAGCHEM CORP	+86-13806087780	sale@simagchem.com	China	17365	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	32161	58
Career Henan Chemica Co	+86-0371-86658258 +8613203830695	laboratory@coreychem.com	China	30239	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	86-571-88216897,88216896 13588875226	sales@hzclap.com	CHINA	6312	58

Supplier	Advantage
Accendatech Co., Ltd.	58
career henan chemical co	58
Hubei Jusheng Technology Co.,Ltd.	58
Standardpharm Co. Ltd.	58
Chongqing Chemdad Co., Ltd	58
CONIER CHEM AND PHARMA LIMITED	58
SIMAGCHEM CORP	58
TargetMol Chemicals Inc.	58
Career Henan Chemica Co	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	58

View Lastest Price from Epothilone A manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-11-19	Epothilone A 152044-53-6	US $43.00-143.00 / mg		99.48%	10g	TargetMol Chemicals Inc.
2021-11-25	Epothilone A 152044-53-6	US $10.00 / g	1KG	99%	5ton/Month	Qiuxian Baitai New Material Co., LTD
2020-05-03	Epothilone A 152044-53-6	US $0.00-0.00 / Kg	1KG	99.0%	800 ton	Shaanxi Dideu Medichem Co. Ltd

Epothilone A
152044-53-6
US $43.00-143.00 / mg
99.48%
TargetMol Chemicals Inc.

Epothilone A
152044-53-6
US $10.00 / g
99%
Qiuxian Baitai New Material Co., LTD

Epothilone A
152044-53-6
US $0.00-0.00 / Kg
99.0%
Shaanxi Dideu Medichem Co. Ltd

152044-53-6(Epothilone A)Related Search:

Amphotericin B (1S,3S,7S,10R,11S,12S,16R)-3-[(1E)-2-[2-(Aminomethyl)-4-thiazolyl]-1-methylethenyl]-7,11-dihydroxy-8,8,10,12,16-pentamethyl-4,17-dioxabicyclo[14.1.0]heptadecane-5,9-dione Epothilone B Oxacyclohexadec-13-ene-2,6-dione, 4,8-dihydroxy-5,5,7,9-tetramethyl-16-(1E)-1-methyl-2-(2-methyl-4-thiazolyl)ethenyl-, (4S,7R,8S,9S,13Z,16S)- Epothilone D

epothilone E ALLYL MYRISTATE Cyclopentadecanolide Epothilone A

1of2

4,17-Dioxabicyclo14.1.0heptadecane-5,9-dione, 7,11-dihydroxy-8,8,10,12-tetramethyl-3-(1E)-1-methyl-2-(2-methyl-4-thiazolyl)ethenyl-, (1S,3S,7S,10R,11S,12S,16R)- Epothilone-S (1S,3S,7S,10R,11S,12S,16R)-7,11-Dihydroxy-8,8,10,12-tetramethyl-3-[(1E)-1-methyl-2-(2-methyl-4-thiazolyl)ethenyl]-4,17-dioxabicyclo[14.1.0]heptadecane-5,9-dione Epothile 4,17-Dioxabicyclo[14.1.0]heptadecane-5,9-dione,7,11-dihydroxy-8,8,10,12-tetraMethyl-3- [(1E)-1-Methy Ixabepilone Impurity 5 (Epothilone A) (1S,3S,7S,10R,11S,12S,16R,E)-7,11-dihydroxy-8,8,10,12-tetramethyl-3-(1-(2-methylthiazol-4-yl)prop-1-en-2-yl)-4,17-dioxa-bicyclo[14.1.0]heptadecane-5,9-dione (1S,3S,7S,10R,11S,12S,16R)-7,11-Dihydroxy-8,8,10,12-tetramethyl-3-[(1E)-1-methyl-2-(2-methyl-4-thiazolyl)ethenyl]-4,17-dioxabicyclo[14.1.0]heptadecane-5,9-dione Epothilone A Epothilone A (1S,3S,7S,10R,11S,12S,16R)-7,11-Dihydroxy-8,8,10,12-tetramethyl-3-[(1E)-1-methyl-2-(2-methyl-4-thiazolyl)ethenyl]-4,17-dioxabicyclo[14.1.0]heptadecane-5,9-dione EPOTHILONE A 4,17-Dioxabicyclo[14.1.0]heptadecane-5,9-dione,7,11-dihydroxy-8,8,10,12-tetramethyl-3- [(1E)-1-methyl-2-(2-methyl-4-thiazolyl)- ethenyl]-,(1R,3R,7R,10S,11R,12R,16S)-rel- CS-1899 CS-555 Ixabepilone Impurity 5 (-)-EPOTHILONE A Epothilon A Epothilone A USP/EP/BP (1S,3S,7S,10R,11S,12S,16R)-7,11-Dihydroxy-8,8,10,12-tetramethyl-3-((E)-1-(2-methylthiazol-4-yl)prop-1-en-2-yl)-4,17-dioxabicyclo[14.1.0]heptadecane-5,9-dione Epothilone A (Epo A) Ebomycin A epothile|||Epo A 152044-53-6 C26H39NO6S Chiral Reagents Inhibitors Intermediates & Fine Chemicals Pharmaceuticals Sulfur & Selenium Compounds