LEPTOMYCIN A
- CAS No.
- 87081-36-5
- Chemical Name:
- LEPTOMYCIN A
- Synonyms
- PD-118607;NSC 369326;Antibiotic PD-118607;Antibiotic ATS-1287A;LEPTOMYCIN A USP/EP/BP;QECBVZBMGUAZDL-DLWOFZAMSA-N;ATS 1287A, PD 118607, JildaMycin;19-(3,6-Dihydro-3-methyl-6-oxo-2H-pyran-2-yl)-6-hydroxy-3,5,7,9,11,15,17-heptamethyl-8-oxo-2,10,12,16,18-nonadecapentaenoic acid;19-(3,6-dihydro-3-methyl-6-oxo-2h-pyran-2-yl)-3,5,7,9,11,15,17-heptamethyl-6-hydroxy-8-oxo-2,10,12,16,18-nonadecapentaenoic acid;(2E,5S,6R,7S,9R,10E,12E,15R,16Z,18E)-6-hydroxy-3,5,7,9,11,15,17-heptamethyl-19-[(2S,3S)-3-methyl-6-oxo-3,6-dihydro-2H-pyran-2-yl]-8-oxononadeca-2,10,12,16,18-pentaenoic acid
- CBNumber:
- CB6972730
- Molecular Formula:
- C32H46O6
- Molecular Weight:
- 526.7
- MDL Number:
- MFCD01711669
- MOL File:
- 87081-36-5.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |    GHS02,GHS06,GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H225-H301+H311+H331-H370 | |||||||||
| Precautionary statements | P210-P260-P280-P301+P310-P311 | |||||||||
| Hazard Codes | F,T | |||||||||
| Risk Statements | 11-23/24/25-39/23/24/25 | |||||||||
| Safety Statements | 16-36/37-45 | |||||||||
| RIDADR | UN 1230 3/PG 2 | |||||||||
| WGK Germany | 1 | |||||||||
| HS Code | 3822000000 | |||||||||
| NFPA 704 |
|
LEPTOMYCIN A price More Price(7)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 21762 | Leptomycin A ≥99% | 87081-36-5 | 50μg | $44 | 2024-03-01 | Buy |
| Cayman Chemical | 21762 | Leptomycin A ≥99% | 87081-36-5 | 100μg | $84 | 2024-03-01 | Buy |
| Cayman Chemical | 21762 | Leptomycin A ≥99% | 87081-36-5 | 500μg | $321 | 2024-03-01 | Buy |
| TRC | L329653 | Leptomycin A | 87081-36-5 | 50μg | $45 | 2021-12-16 | Buy |
| Apolloscientific | BIL2100 | Leptomycin A | 87081-36-5 | 100ug | $95 | 2021-12-16 | Buy |
LEPTOMYCIN A Chemical Properties,Uses,Production
Description
Leptomycin A is an inhibitor of CRM1 (exportin 1) that blocks CRM1 interaction with nuclear export signals, preventing the nuclear export of a broad range of proteins. Leptomycin A inhibits Rev translocation, though less potently than leptomycin B with IC50 values of 0.8 and 0.1 nM, respectively after 7 hours. Rev export to the cytoplasm is required for HIV-1 replication. Leptomycin A was originally identified as an antifungal agent.
Uses
Leptomycin A, a methyl analogue of leptomycin B, is a minor component of the leptomycin complex produced by selected Streptomyces species. Leptomycin B is a potent inhibitor of the nuclear transport receptor CRM1. Leptomycin A is also likely to inhibit nuclear transport and may offer differences in exporter selectivity. Leptomycin A shows antimicrobial activity against Schizosaccaromyces pombe and Mucor rouxianus.
Uses
Leptomycin A is an antifungal antibiotic.
Definition
ChEBI: A leptomycin having all-trans double bonds and a seventh methyl substituent at position 17.
LEPTOMYCIN A Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32161 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-029-89586680 +86-18192503167 | 1026@dideu.com | China | 7724 | 58 |
| Shanghai Minbiotech Co., Ltd. | +8617315815539 | sales@minbiotech.com | CHINA | 129 | 58 |
| AFINE CHEMICALS LIMITED | +86-0571-85134551 | sales@afinechem.com | China | 15352 | 58 |
| BOC Sciences | 16314854226; +16314854226 | inquiry@bocsci.com | United States | 19741 | 58 |
| Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 | sales@chemhifuture.com | China | 3135 | 58 |
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38631 | 58 | |
| Wuhan Jingkang en Biomedical Technology Co., Ltd | +8613720134139 | orders@jknbiochem.com | China | 5221 | 58 |
| Chembest Research Laboratories Limited | +86-21-20908456 | sales@BioChemBest.com | China | 6005 | 61 |
| Shanghai Witofly Chemical Co.,Ltd | sales@witofly.com | China | 2864 | 52 |
View Lastest Price from LEPTOMYCIN A manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-10-28 | Leptomycin A
87081-36-5
|
US $210.00 / μg | 10g | TargetMol Chemicals Inc. |
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- Leptomycin A
87081-36-5
- US $210.00 / μg
- TargetMol Chemicals Inc.