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ChemicalBook >> CAS DataBase List >>2-Propenamide, 3-(3-chlorophenyl)-N-[2-[4-(methylsulfonyl)-1-piperazinyl]-2-oxoethyl]-, (2E)-

2-Propenamide, 3-(3-chlorophenyl)-N-[2-[4-(methylsulfonyl)-1-piperazinyl]-2-oxoethyl]-, (2E)-

2-Propenamide, 3-(3-chlorophenyl)-N-[2-[4-(methylsulfonyl)-1-piperazinyl]-2-oxoethyl]-, (2E)- Structure
2-Propenamide, 3-(3-chlorophenyl)-N-[2-[4-(methylsulfonyl)-1-piperazinyl]-2-oxoethyl]-, (2E)- structure
CAS No.
2505001-54-5
Chemical Name:
2-Propenamide, 3-(3-chlorophenyl)-N-[2-[4-(methylsulfonyl)-1-piperazinyl]-2-oxoethyl]-, (2E)-
Synonyms
2-Propenamide, 3-(3-chlorophenyl)-N-[2-[4-(methylsulfonyl)-1-piperazinyl]-2-oxoethyl]-, (2E)-;growth,inhibit,KLF5,SR 15006,Krüppel-like factor,SR15006,colorectal cancer cells,cycle,Inhibitor,KLF,cyclins,SR-15006
CBNumber:
CB69766570
Molecular Formula:
C16H20ClN3O4S
Molecular Weight:
385.87
MDL Number:
MOL File:
2505001-54-5.mol
Last updated:2024-07-02 08:55:14
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2-Propenamide, 3-(3-chlorophenyl)-N-[2-[4-(methylsulfonyl)-1-piperazinyl]-2-oxoethyl]-, (2E)- Properties

Density 1.41±0.1 g/cm3(Predicted)
storage temp. 4°C, protect from light
solubility DMSO : 100 mg/mL (259.15 mM; Need ultrasonic)
pka 13.21±0.46(Predicted)
form Solid
color White to off-white

2-Propenamide, 3-(3-chlorophenyl)-N-[2-[4-(methylsulfonyl)-1-piperazinyl]-2-oxoethyl]-, (2E)- Chemical Properties,Uses,Production

Biological Activity

SR15006 is a inhibitor of Krüppel-like factor 5 (KLF5) with an IC50 of 41.6 nM in DLD-1/pGL4.18hKLF5p cells)[1]. SR15006 (1 μM or 10 μM; DLD-1 CRC cells) causes a significant reduction in the levels of tested cyclins over the course of 72 hours[1].

References

[1]. Kim J, et al. The Novel Small-Molecule SR18662 Efficiently Inhibits the Growth of Colorectal Cancer In Vitro and In Vivo. Mol Cancer Ther. 2019;18(11):1973-1984.

2-Propenamide, 3-(3-chlorophenyl)-N-[2-[4-(methylsulfonyl)-1-piperazinyl]-2-oxoethyl]-, (2E)- Preparation Products And Raw materials

Raw materials

Preparation Products

2-Propenamide, 3-(3-chlorophenyl)-N-[2-[4-(methylsulfonyl)-1-piperazinyl]-2-oxoethyl]-, (2E)- Suppliers

Global( 15)Suppliers
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ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32760 60
Shanghai Lollane Biological Technology Co.,Ltd. 021-52996696，15000506266 15000506266 China 4287 55
Tianjin Kailiqi Biotechnology Co., Ltd. 15076683720 klq@cw-bio.com China 3769 55
ShangHai Biochempartner Co.,Ltd 17754423994 17754423994 2853530910@QQ.com China 8017 62
Shanghai Chaolan Chemical Technology Center QQ:65489617 15618227136 info@SuperLan-chem.com China 9941 58
Shanghai Dongyang Biotechnology Co., Ltd. 0512-0512-13601744364 13601744364 chemsharker@126.com China 896 58
Absin Bioscience Inc. 021-38015121 15000105423 chenjw@absin.cn China 24734 58
Jinan Jiuli Biotechnology Co. , Ltd. 15865264761 486064515@qq.com China 2780 58
InvivoChem 13549236410 sales@invivochem.cn China 6755 58
TargetMol Chemicals Inc. 4008200310 marketing@tsbiochem.com China 23963 58
Supplier Advantage
ATK CHEMICAL COMPANY LIMITED 		60
Shanghai Lollane Biological Technology Co.,Ltd. 55
Tianjin Kailiqi Biotechnology Co., Ltd. 55
ShangHai Biochempartner Co.,Ltd 62
Shanghai Chaolan Chemical Technology Center 58
Shanghai Dongyang Biotechnology Co., Ltd. 58
Absin Bioscience Inc. 58
Jinan Jiuli Biotechnology Co. , Ltd. 58
InvivoChem 58
TargetMol Chemicals Inc. 58

2-Propenamide, 3-(3-chlorophenyl)-N-[2-[4-(methylsulfonyl)-1-piperazinyl]-2-oxoethyl]-, (2E)- Spectrum

2-Propenamide, 3-(3-chlorophenyl)-N-[2-[4-(methylsulfonyl)-1-piperazinyl]-2-oxoethyl]-, (2E)-(2505001-54-5)1HNMR
2-Propenamide, 3-(3-chlorophenyl)-N-[2-[4-(methylsulfonyl)-1-piperazinyl]-2-oxoethyl]-, (2E)- growth,inhibit,KLF5,SR 15006,Krüppel-like factor,SR15006,colorectal cancer cells,cycle,Inhibitor,KLF,cyclins,SR-15006 2505001-54-5